solo per uso di ricerca
AZD7762 Chk inibitore
N. Cat.S1532
Struttura chimica
Peso molecolare: 362.42
Vai a
Controllo Qualità
Lotto:
Purezza:
99.98%
99.98
Coltura cellulare, trattamento e concentrazione di lavoro
| Linee cellulari | Tipo di saggio | Concentrazione | Tempo di incubazione | Formulazione | Descrizione dellattività | PMID |
|---|---|---|---|---|---|---|
| KASUMI-1 | Growth Inhibition Assay | IC50=0.000234 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.000415 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.000425 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.00643 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.0142 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.02849 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=0.0312 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.03142 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=0.03251 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.03417 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.03442 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.03579 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.03896 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.04022 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.04203 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.04316 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.04592 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.05158 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.06025 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.06102 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.06115 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=0.06136 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.06196 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.06255 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.0646 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=0.07146 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.0739 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.07486 μM | SANGER | |||
| OC-314 | Growth Inhibition Assay | IC50=0.07807 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.08421 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.08659 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.0871 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.08806 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.08807 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.09091 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=0.09903 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.09918 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.10033 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.102 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=0.10554 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.11063 μM | SANGER | |||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.11093 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.1186 μM | SANGER | |||
| H9 | Growth Inhibition Assay | IC50=0.12165 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.1225 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.12484 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=0.12843 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=0.13041 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.13064 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.13128 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.1316 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.13325 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.13369 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=0.13476 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.1368 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=0.13687 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.13894 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.13925 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.14288 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.14463 μM | SANGER | |||
| D-566MG | Growth Inhibition Assay | IC50=0.1469 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.14842 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.14967 μM | SANGER | |||
| YH-13 | Growth Inhibition Assay | IC50=0.15674 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=0.15786 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.15847 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.16011 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=0.16166 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.16311 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.16413 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.16503 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=0.16535 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.1683 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.16847 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.17171 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.17464 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=0.17827 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.18599 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=0.18815 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.18905 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.19278 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.19561 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.19761 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.19782 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.19832 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.20117 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.20318 μM | SANGER | |||
| TI-73 | Growth Inhibition Assay | IC50=0.20873 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.2097 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.21429 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.22062 μM | SANGER | |||
| EPLC-272H | Growth Inhibition Assay | IC50=0.22068 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=0.22235 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.22298 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.22454 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.22557 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.2257 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.22633 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=0.22666 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=0.23036 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.23056 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=0.23238 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.2385 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.24243 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=0.24339 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.24401 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.24451 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.24568 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=0.24626 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=0.24671 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=0.24761 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=0.25654 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.25768 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=0.26064 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.26678 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.27059 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=0.27089 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.27097 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.27304 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.27385 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=0.2798 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.2806 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.28134 μM | SANGER | |||
| H-EMC-SS | Growth Inhibition Assay | IC50=0.28354 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.2868 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=0.2891 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.29008 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.29154 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.29279 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.29406 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.29704 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.29793 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.29802 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.29845 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=0.29855 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.29896 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=0.30265 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=0.30431 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.30665 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.31525 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.31566 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.3165 μM | SANGER | |||
| NBsusSR | Growth Inhibition Assay | IC50=0.31819 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.32021 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=0.32353 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.32489 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.32594 μM | SANGER | |||
| D-423MG | Growth Inhibition Assay | IC50=0.33142 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.33343 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.3381 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.34584 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.34596 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.34677 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.34682 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.34875 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=0.34887 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.35584 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.35696 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.36482 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=0.36985 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.37497 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.37606 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.37948 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.38353 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.38567 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.38712 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.38792 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.38823 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.3897 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.39118 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.40131 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.40151 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=0.40191 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.40286 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=0.41092 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.41172 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.41225 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.41661 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.41714 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=0.42138 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.42885 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.43049 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.43162 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.43288 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.44185 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.44187 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.44293 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.45103 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.45136 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=0.45278 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.45293 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.4546 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.45612 μM | SANGER | |||
| MOLT-13 | Growth Inhibition Assay | IC50=0.46294 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.46419 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.46603 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.46868 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.47035 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.48234 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=0.48626 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=0.4903 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.49115 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.4927 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.49921 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.49922 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.50633 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.51344 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.51437 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.52019 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=0.52114 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.52551 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.53078 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=0.53466 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.53657 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.53774 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.53881 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=0.54077 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.5558 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=0.55933 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=0.56326 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.56522 μM | SANGER | |||
| KNS-62 | Growth Inhibition Assay | IC50=0.56553 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.57121 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.57421 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.57497 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.58162 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=0.58375 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.58382 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.58833 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.59118 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=0.59129 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=0.60328 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.61787 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.61861 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.6201 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.62788 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=0.63712 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.63721 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.64023 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=0.64935 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.65036 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.6565 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.65805 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.66068 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.66223 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=0.66361 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.67625 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.67671 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.67852 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.68306 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.68804 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.68928 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.69217 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=0.69812 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.70549 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.70631 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.70765 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.70781 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=0.72124 μM | SANGER | |||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.72257 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.7262 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.73552 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.73593 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.73864 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=0.7403 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.74584 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=0.74806 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.74908 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.74968 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.74984 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.75456 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=0.76262 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=0.77355 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.77553 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.78211 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.78432 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.78939 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.7924 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=0.79651 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.80487 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=0.81349 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.81371 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=0.8244 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.82636 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.83474 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.83711 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.84484 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=0.84556 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.84591 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=0.85882 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=0.86185 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=0.86536 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.87334 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=0.87731 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.87995 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.88097 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=0.88602 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.89417 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.89777 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.90316 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.90578 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.90943 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.90984 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.91552 μM | SANGER | |||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.91852 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.92452 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.93251 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.93557 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.93665 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.94092 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.94127 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=0.94227 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.94237 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=0.96749 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.9696 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.97028 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.97945 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.98027 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=0.98378 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=0.98462 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.98473 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.98592 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=0.99258 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=1.00412 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=1.01813 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=1.01859 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=1.0352 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=1.03971 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=1.04 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=1.05075 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=1.05336 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=1.06828 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=1.07773 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=1.09352 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=1.10973 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=1.11785 μM | SANGER | |||
| SW900 | Growth Inhibition Assay | IC50=1.12251 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=1.12291 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=1.14353 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=1.14714 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=1.1667 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=1.19347 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=1.19515 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=1.19819 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=1.21334 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=1.21367 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=1.21418 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=1.21478 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=1.21773 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=1.22758 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=1.23359 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=1.23525 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=1.24343 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=1.26666 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=1.26672 μM | SANGER | |||
| BT-549 | Growth Inhibition Assay | IC50=1.26782 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=1.2864 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=1.30672 μM | SANGER | |||
| SCH | Growth Inhibition Assay | IC50=1.32503 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=1.34551 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=1.37564 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=1.38168 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=1.39051 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=1.39501 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=1.39986 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=1.40231 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=1.41187 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=1.41795 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=1.41954 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=1.42018 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=1.42176 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=1.42257 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=1.43128 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=1.44319 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=1.46151 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=1.46382 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=1.48104 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=1.48613 μM | SANGER | |||
| A549 | Growth Inhibition Assay | IC50=1.48833 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=1.49026 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=1.4938 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=1.52313 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=1.52961 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=1.53706 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=1.5825 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=1.58328 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=1.60227 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=1.6038 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=1.60591 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=1.61345 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=1.63456 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=1.69256 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=1.69983 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=1.70067 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=1.71785 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=1.72407 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=1.72963 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=1.76749 μM | SANGER | |||
| EC-GI-10 | Growth Inhibition Assay | IC50=1.77556 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=1.78642 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=1.80267 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=1.80853 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=1.81214 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=1.84746 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=1.8707 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=1.87342 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=1.88676 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=1.90787 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=1.90932 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=1.92035 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=1.99105 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=2.00154 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=2.00372 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=2.00898 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=2.04059 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.05442 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=2.07098 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=2.08603 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=2.10041 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=2.12541 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=2.13147 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=2.15307 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=2.17015 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=2.17788 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=2.19271 μM | SANGER | |||
| RH-18 | Growth Inhibition Assay | IC50=2.19369 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.19596 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=2.29973 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=2.32659 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=2.33868 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=2.34603 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=2.38204 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=2.38794 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=2.39805 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=2.43727 μM | SANGER | |||
| NCI-H2291 | Growth Inhibition Assay | IC50=2.46994 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=2.50249 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=2.50305 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=2.52934 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=2.53747 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=2.61116 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=2.66161 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=2.66611 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=2.67374 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=2.70406 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=2.71627 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=2.71949 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=2.73756 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=2.86389 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=2.88431 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=2.92139 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=2.92257 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=2.99939 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=3.02636 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=3.03463 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=3.0671 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=3.09693 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=3.11827 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=3.12141 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=3.18474 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=3.2326 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=3.28489 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=3.29179 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=3.3281 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=3.44761 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=3.52417 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=3.53214 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=3.562 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=3.57986 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=3.59867 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=3.60009 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=3.81119 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=4.01396 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=4.23597 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=4.25191 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=4.29271 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=4.31345 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=4.352 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=4.41913 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=4.45528 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=4.52362 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=4.54871 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=4.71694 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=4.83841 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=4.84991 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=5.14506 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=5.14859 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=5.29782 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=5.44014 μM | SANGER | |||
| NCI-H2029 | Growth Inhibition Assay | IC50=5.48022 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=5.66889 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=5.70345 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=5.7081 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=5.74182 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=5.74564 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=5.75333 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=5.77563 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=5.86894 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=6.24585 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=6.39403 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=6.79722 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=6.99591 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=7.12299 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=7.87127 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=8.02984 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=8.16024 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=8.28886 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=8.93093 μM | SANGER | |||
| LU-135 | Growth Inhibition Assay | IC50=9.03452 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=9.28844 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=9.33919 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=9.53596 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=10.0229 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=10.4369 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=10.5255 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=10.6852 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=12.3172 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=12.5284 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=12.6333 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=12.8771 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=13.2365 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=14.5461 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=14.8582 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=15.1741 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=15.4474 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=15.7611 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=16.0124 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=19.726 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=20.3577 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=20.7836 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=21.5541 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=23.4086 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=23.7673 μM | SANGER | |||
| ECC10 | Growth Inhibition Assay | IC50=25.571 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=27.8316 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=28.3248 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=28.4192 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=31.4912 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=32.8858 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=33.0843 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=33.5145 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=37.3585 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=40.6295 μM | SANGER | |||
| NCI-H1666 | Growth Inhibition Assay | IC50=42.4488 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=46.4196 μM | SANGER | |||
| SW1116 | Growth Inhibition Assay | IC50=48.1756 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=48.5026 μM | SANGER | |||
| Clicca per visualizzare più dati sperimentali sulle linee cellulari | ||||||
Informazioni chimiche, conservazione e stabilità
| Peso molecolare | 362.42 | Formula | C17H19FN4O2S |
Conservazione (Dalla data di ricezione) | |
|---|---|---|---|---|---|
| N. CAS | 860352-01-8 | Scarica SDF | Conservazione delle soluzioni stock |
|
|
| Sinonimi | N/A | Smiles | C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N | ||
Solubilità
|
In vitro |
DMSO
: 73 mg/mL
(201.42 mM)
Water : Insoluble Ethanol : Insoluble |
Calcolatore di Molarità
Calcolatore di Diluizione
Calcolatore del Peso Molecolare
|
In vivo |
|||||
Calcolatore di formulazione in vivo (Soluzione chiara)
Passo 1: Inserire le informazioni di seguito (Consigliato: Un animale aggiuntivo per tenere conto della perdita durante lesperimento)
mg/kg
g
μL
Passo 2: Inserire la formulazione in vivo (Questo è solo il calcolatore, non la formulazione. Contattateci prima se non cè una formulazione in vivo nella sezione Solubilità.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
Risultati del calcolo:
Concentrazione di lavoro: mg/ml;
Metodo per preparare il liquido master di DMSO: mg farmaco predissolto in μL DMSO ( Concentrazione del liquido master mg/mL, Vi preghiamo di contattarci prima se la concentrazione supera la solubilità del DMSO del lotto del farmaco. )
Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungereμL PEG300, mescolare e chiarire, quindi aggiungereμL Tween 80, mescolare e chiarire, quindi aggiungere μL ddH2O, mescolare e chiarire.
Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungere μL Olio di mais, mescolare e chiarire.
Nota: 1. Si prega di assicurarsi che il liquido sia limpido prima di aggiungere il solvente successivo.
2. Assicurarsi di aggiungere il/i solvente/i in ordine. È necessario assicurarsi che la soluzione ottenuta, nellaggiunta precedente, sia una soluzione limpida prima di procedere allaggiunta del solvente successivo. Metodi fisici come il vortex, gli ultrasuoni o il bagno dacqua calda possono essere utilizzati per facilitare la dissoluzione.
Meccanismo dazione
| Targets/IC50/Ki |
Chk1
(Cell-free assay) 5 nM
Chk2
(Cell-free assay) <10 nM
|
|---|---|
| In vitro |
AZD7762, un inibitore di Chk1 più selettivo, inibisce la fosforilazione di Chk1 di un peptide cdc25C legandosi reversibilmente al sito di legame dell'ATP di Chk1, con IC50 di 5 nM e Ki di 3,6 nM. Questo composto induce l'arresto cellulare con EC50 di 0,620 μM e abroga significativamente l'arresto in G2 indotto dalla camptotecina con una EC50 di 10 nM, bloccando la degradazione dipendente da Chk1 di Cdc25A e l'attivazione della Ciclina A. Esso (300 nM) aumenta l'efficacia antitumorale contro SW620 e MDA-MB-231 riducendo i valori di GI50 da 24,1 nM e 2,25 μM a 1,08 nM e 0,15 μM, rispettivamente. Questa sostanza chimica mostra citotossicità contro una varietà di linee cellulari di neuroblastoma con p53 wild type, mutazione p53, amplificazione Mdm2 o delezione p14 con valori di IC50 compresi tra 82,6 e 505,9 nM. |
| Saggio chinasico |
Saggio Chk1 Kinase
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La Chk1 umana ricombinante è espressa come una fusione di S-transferasi in cellule di insetto usando un vettore di baculovirus e purificata mediante cromatografia di affinità. Un substrato peptidico sintetico (N-biotinilamminoesanoil-KKVSRSGLYRSPMPENLNRPR) per Chk1 viene sintetizzato. Le concentrazioni finali del saggio di peptide e ATP (freddo + 40 nCi [33P]ATP) sono rispettivamente 0,8 e 1 μM. Diverse concentrazioni di questo composto, tampone contenente il peptide e la Chk1 chinasi e ATP, vengono aggiunte sequenzialmente a una piastra di saggio a 384 pozzetti. La piastra viene incubata per 2 ore, la reazione viene interrotta con l'aggiunta di tampone contenente EDTA e perle per saggio di scintillazione a prossimità, e le piastre vengono lette usando un lettore TopCount. L'analisi dei dati viene eseguita per determinare una risposta alla dose (IC50).
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| In vivo |
AZD7762 da solo a 25 mg/kg mostra scarsa attività antitumorale nei topi xenotrapiantati H460-DNp53 e nei topi xenotrapiantati SW620, ma quando somministrato in combinazione, questo composto mostra una significativa efficacia antitumorale nei due topi xenotrapiantati con un log cell kill di 0,9 o una percentuale trattato/controllo (%T/C) del 26 anche a basse dosi di 12,5 mg. La somministrazione di questa sostanza chimica in combinazione nel ratto xenotrapiantato H460-DNp53 inibisce il volume del tumore in modo dose-dipendente con valori di %T/C di 48 e 32 per 10 e 20 mg/kg, rispettivamente. Questo composto (25 mg/kg) in combinazione causa una regressione tumorale completa nei topi xenotrapiantati SW620 con il %T/C che aumenta significativamente a -66% e -67%, rispettivamente. |
Riferimenti |
Applicazioni
| Metodi | Biomarcatori | Immagini | PMID |
|---|---|---|---|
| Western blot | pChk1 / Chk1 / Wee1 / p21 / p53 |
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29963769 |
| Growth inhibition assay | Cell viability |
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23715154 |
Informazioni sullo studio clinico
(dati da https://clinicaltrials.gov, aggiornato il 2024-05-22)
| Numero NCT | Reclutamento | Condizioni | Sponsor/Collaboratori | Data di inizio | Fasi |
|---|---|---|---|---|---|
| NCT00937664 | Terminated | Cancer|Solid Tumors|Advanced Solid Malignancies |
AstraZeneca |
July 2009 | Phase 1 |
| NCT00473616 | Terminated | Advanced Solid Tumors|Cancer|Advanced Solid Malignancies |
AstraZeneca |
May 2007 | Phase 1 |
| NCT00413686 | Completed | Solid Tumors |
AstraZeneca |
December 2006 | Phase 1 |
Supporto tecnico
Istruzioni per la manipolazione
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Domande Frequenti
Domanda 1:
If I want to use it for i.p. injection, can I use DMSO to dissolve this compound?
Risposta:
Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is considered a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate it for i.v. injection.
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