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Salinomycin (Procoxacin) Wnt/beta-catenin inibitore

Name: Salinomycin (Procoxacin)
Brand: Selleck Chemicals
SKU: S8129
Rating: 5 (22 reviews)

N. Cat.S8129

La Salinomycin, tradizionalmente usata come farmaco anticoccidico, ha recentemente dimostrato di possedere effetti antitumorali e anti-cellule staminali tumorali (CSC).

Salinomycin (Procoxacin) Wnt/beta-catenin inibitore Chemical Structure

Struttura chimica

Peso molecolare: 751.00

Vai a

Controllo Qualità

Lotto: Purezza: >97%

Citato su Nature Medicine per la sua qualità superiore
COA
Scheda dati
SDS

Citato su Nature Medicine per la sua qualità superiore
COA
NMR
Scheda dati
SDS

Citato su Nature Medicine per la sua qualità superiore
COA
Microanalisi

Perché la microanalisi?
Scheda dati
SDS

Target correlati	JAK TGF-beta/Smad ERK GSK-3 ROCK Hedgehog/Smoothened PKA Secretase STAT Casein Kinase
Altro Wnt/beta-catenin Inibitori	IWR-1-endo PRI-724 (Foscenvivint) IWP-2 Tegatrabetan (BC-2059) Isoquercitrin ICG-001 SKL2001 BML-284 Hydrochloride (Wnt agonist 1, AMBMP) PNU-74654 FH535

Coltura cellulare, trattamento e concentrazione di lavoro

Linee cellulari	Tipo di saggio	Concentrazione	Tempo di incubazione	Descrizione dellattività	PMID
HL60 cells	Proliferation assay		72 h	Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50=0.29 μM	25644674
MV4-11 cells	Proliferation assay		72 h	Antiproliferative activity against human MV4-11 cells after 72 hrs, IC50=0.33 μM	26163197
LoVo cells	Proliferation assay		72 h	Antiproliferative activity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB method, IC50=0.36 μM	25644674
VCaP cells	Proliferation assay			Antiproliferative activity against human VCaP cells, EC50=0.38 μM	23063400
LS180 cells	Proliferation assay		72 h	Antiproliferative activity against human LS180 cells assessed as growth inhibition after 72 hrs by SRB method, IC50=0.61 μM	25644674
HT-29 cells	Proliferation assay		72 h	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by SRB method, IC50=1.03 μM	25644674
SW707 cells	Proliferation assay		72 h	Antiproliferative activity against human SW707 cells assessed as growth inhibition after 72 hrs by SRB method, IC50=1.73 μM	25644674
HL60/Vinc cells	Cytotoxicity assay		72 h	Cytotoxicity against vincristine-resistant human HL60/Vinc cells incubated for 72 hrs by MTT assay, IC50=3.44 μM	23079523
BALB/3T3 cells	Cytotoxicity assay		72 h	Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by MTT assay, IC50=28.08 μM	23079523
VCaP	Antiproliferative assay			Antiproliferative activity against human VCaP cells, EC50 = 0.38 μM.	23063400
HL60	Cytotoxicity assay		72 hrs	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay, IC50 = 0.44 μM.	23079523
LoVo	Cytotoxicity assay		72 hrs	Cytotoxicity against human LoVo cells incubated for 72 hrs by MTT assay, IC50 = 1.11 μM.	23079523
HL60/Vinc	Cytotoxicity assay		72 hrs	Cytotoxicity against vincristine-resistant human HL60/Vinc cells incubated for 72 hrs by MTT assay, IC50 = 3.44 μM.	23079523
LoVo/DX	Cytotoxicity assay		72 hrs	Cytotoxicity against doxorubicin-resistant human LoVo/DX cells incubated for 72 hrs by MTT assay, IC50 = 6.23 μM.	23079523
BALB/3T3	Cytotoxicity assay		72 hrs	Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by MTT assay, IC50 = 28.08 μM.	23079523
LoVo/DX	Antiproliferative assay			Antiproliferative activity against human LoVo/DX cells, IC50 = 1 μM.	24631190
HL60	Antiproliferative assay			Antiproliferative activity against human HL60 cells, IC50 = 1.2 μM.	24631190
LoVo	Antiproliferative assay			Antiproliferative activity against human LoVo cells, IC50 = 1.5 μM.	24631190
HL60/Vinc	Antiproliferative assay			Antiproliferative activity against human HL60/Vinc cells, IC50 = 4.7 μM.	24631190
BALB/3T3	Antiproliferative assay			Antiproliferative activity mouse BALB/3T3 cells, IC50 = 25.8 μM.	24631190
HL60	Antiproliferative assay		72 hrs	Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 0.29 μM.	25644674
LoVo	Antiproliferative assay		72 hrs	Antiproliferative activity against human LoVo cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 0.36 μM.	25644674
LS180	Antiproliferative assay		72 hrs	Antiproliferative activity against human LS180 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 0.61 μM.	25644674
LoVo/DX	Antiproliferative assay		72 hrs	Antiproliferative activity against human doxorubicin-resistant LoVo/DX cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 0.76 μM.	25644674
HT-29	Antiproliferative assay		72 hrs	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 1.03 μM.	25644674
SW707	Antiproliferative assay		72 hrs	Antiproliferative activity against human SW707 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 1.73 μM.	25644674
HL60/Vinc	Antiproliferative assay		72 hrs	Antiproliferative activity against human vincristine-resistant HL60/Vinc cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 2.09 μM.	25644674
BALB/3T3	Antiproliferative assay		72 hrs	Antiproliferative activity against mouse BALB/3T3 cells assessed as growth inhibition after 72 hrs by SRB method, IC50 = 9.33 μM.	25644674
MV4-11	Antiproliferative assay		72 hrs	Antiproliferative activity against human MV4-11 cells after 72 hrs, IC50 = 0.33 μM.	26163197
LoVo	Antiproliferative assay		72 hrs	Antiproliferative activity against human LoVo cells after 72 hrs, IC50 = 0.53 μM.	26163197
LoVo/DX	Antiproliferative assay		72 hrs	Antiproliferative activity against doxorubicin-resistant human LoVo/DX cells after 72 hrs, IC50 = 0.59 μM.	26163197
BALB/3T3	Antiproliferative assay		72 hrs	Antiproliferative activity against mouse BALB/3T3 cells after 72 hrs, IC50 = 27.76 μM.	26163197
JIMT1	Cytotoxicity assay		72 hrs	Cytotoxicity against human JIMT1 cells after 72 hrs by MTT assay, IC50 = 0.52 μM.	27326340
MCF7	Cytotoxicity assay		72 hrs	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 0.59 μM.	27326340
MCF7	Antiproliferative assay		48 hrs	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 2.98 μM.	27876192
MDA-MB-231	Antiproliferative assay		48 hrs	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 6.42 μM.	27876192
MIAPaCa2	Cytotoxicity assay		48 hrs	Cytotoxicity against human MIAPaCa2 cells assessed as decrease in cell viability after 48 hrs by MTS assay	28177244
DU145	Cytotoxicity assay		48 hrs	Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 48 hrs by MTS assay	28177244
BT474	Cytotoxicity assay		48 hrs	Cytotoxicity against human BT474 cells assessed as decrease in cell viability after 48 hrs by MTS assay	28177244
MDA-MB-231	Cytotoxicity assay		48 hrs	Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTS assay	28177244
HT-29	Cytotoxicity assay		48 hrs	Cytotoxicity against human HT-29 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50 = 1.43 μM.	28262526
HGC27	Cytotoxicity assay		48 hrs	Cytotoxicity against human HGC27 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50 = 2.57 μM.	28262526
MDA-MB-231	Cytotoxicity assay		48 hrs	Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay, IC50 = 6.53 μM.	28262526
OV2008	Cytotoxicity assay		72 hrs	Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 3.2 μM.	28651817
OV2008	Cytotoxicity assay		48 hrs	Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay, IC50 = 4.78 μM.	28651817
OV2008	Cytotoxicity assay		24 hrs	Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay, IC50 = 7.44 μM.	28651817
HT-29	Antiproliferative assay		48 hrs	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.43 μM.	28688275
HEK293	Cytotoxicity assay		72 hrs	Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.195 μM.	29466777
HEK293	Cytotoxicity assay		72 hrs	Cytotoxicity against doxycycline inducible T-Rex/K-Ras G12V HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.3295 μM.	29466777
HL60	Cytotoxicity assay		48 hrs	Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 0.58 μM.	29466777
SW480	Cytotoxicity assay		48 hrs	Cytotoxicity against human SW480 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 3.77 μM.	29466777
4T1	Cytotoxicity assay		48 hrs	Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 3.78 μM.	29466777
A549	Cytotoxicity assay		48 hrs	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 3.98 μM.	29466777
HeLa	Cytotoxicity assay		48 hrs	Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 4.49 μM.	29466777
MCF7	Cytotoxicity assay		48 hrs	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 9.08 μM.	29466777
SMMC7721	Cytotoxicity assay		48 hrs	Cytotoxicity against human SMMC7721 cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 12.04 μM.	29466777
BEAS2B	Cytotoxicity assay		48 hrs	Cytotoxicity against human BEAS2B cells assessed as cell growth inhibition after 48 hrs by MTS assay, IC50 = 13.07 μM.	29466777
LoVo	Antiproliferative assay		72 hrs	Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay, IC50 = 0.44 μM.	30025346
LoVo/DX	Antiproliferative assay		72 hrs	Antiproliferative activity against human LoVo/DX cells after 72 hrs by SRB assay, IC50 = 0.69 μM.	30025346
SK-BR-3	Antiproliferative assay		72 hrs	Antiproliferative activity against human SK-BR-3 cells after 72 hrs by SRB assay, IC50 = 0.89 μM.	30025346
JIMT1	Antiproliferative assay		72 hrs	Antiproliferative activity against human JIMT1 cells after 72 hrs by SRB assay, IC50 = 1.3 μM.	30025346
MCF7	Antiproliferative assay		72 hrs	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay, IC50 = 1.5 μM.	30025346
ALL5	Antiproliferative assay		120 hrs	Antiproliferative activity against human ALL5 cells after 120 hrs by MTT assay, IC50 = 2.4 μM.	30025346
MCF10A	Antiproliferative assay		72 hrs	Antiproliferative activity against human MCF10A cells after 72 hrs by SRB assay, IC50 = 46 μM.	30025346
HMLER	Antiproliferative assay			Antiproliferative activity against HMLER cells by MTT assay Breast cancer stem cell, IC50 = 0.1 μM.	30684870
HeLa	Antiproliferative assay			Antiproliferative activity against human HeLa cells by MTT assay, IC50 = 0.32 μM.	30684870
LoVo	Antiproliferative assay			Antiproliferative activity against human LoVo cells by SRB assay, IC50 = 0.44 μM.	30684870
JIMT1	Antiproliferative assay			Antiproliferative activity against human JIMT1 cells, IC50 = 0.52 μM.	30684870
JIMT1	Antiproliferative assay			Antiproliferative activity against human JIMT1 cells by MTT assay, IC50 = 0.52 μM.	30684870
MCF7	Antiproliferative assay			Antiproliferative activity against human MCF7 cells by MTT assay, IC50 = 0.59 μM.	30684870
LoVo/DX	Antiproliferative assay			Antiproliferative activity against human LoVo/DX cells by SRB assay, IC50 = 0.69 μM.	30684870
SKBR3	Antiproliferative assay			Antiproliferative activity against human SKBR3 cells by SRB assay, IC50 = 0.89 μM.	30684870
HT-29	Antiproliferative assay			Antiproliferative activity against human HT-29 cells by MTT assay, IC50 = 1.03 μM.	30684870
JIMT1	Antiproliferative assay			Antiproliferative activity against human JIMT1 cells by SRB assay, IC50 = 1.3 μM.	30684870
MCF7	Antiproliferative assay			Antiproliferative activity against human MCF7 cells by SRB assay, IC50 = 1.5 μM.	30684870
HGC27	Antiproliferative assay			Antiproliferative activity against human HGC27 cells by MTT assay, IC50 = 2.57 μM.	30684870
HT-29	Antiproliferative assay		48 hrs	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 3.21 μM.	30684870
4T1	Antiproliferative assay			Antiproliferative activity against mouse 4T1 cells by MTT assay, IC50 = 3.78 μM.	30684870
A549	Antiproliferative assay			Antiproliferative activity against human A549 cells by MTT assay, IC50 = 3.98 μM.	30684870
MDA-MB-231	Antiproliferative assay			Antiproliferative activity against human MDA-MB-231 cells by SRB assay, IC50 = 6.42 μM.	30684870
MDA-MB-231	Antiproliferative assay			Antiproliferative activity against human MDA-MB-231 cells by MTT assay, IC50 = 6.91 μM.	30684870
HGC27	Antiproliferative assay		48 hrs	Antiproliferative activity against human HGC27 cells after 48 hrs by MTT assay, IC50 = 8.18 μM.	30684870
Caco2	Antiproliferative assay			Antiproliferative activity against human Caco2 cells by MTT assay, IC50 = 12.99 μM.	30684870
U87	Antiproliferative assay			Antiproliferative activity against human U87 cells by MTT assay, IC50 = 38.7 μM.	30684870
MCF10A	Antiproliferative assay			Antiproliferative activity against human MCF10A cells by SRB assay, IC50 = 46 μM.	30684870
HepG2	Cytotoxicity assay		72 hrs	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay, IC50 = 24.5 μM.	30871771
HL60	Cytotoxicity assay		24 hrs	Cytotoxicity against human HL60 cells assessed as growth inhibition after 24 hrs by resazurin dye based assay, GI50 = 6.63 μM.	30986574
HL-60	Function assay		24 hrs	Trypanocidal activity against bloodstream forms of Trypanosoma brucei infected in human HL-60 cells incubated for 24 hrs followed by compound wash out after 72 hrs, GI50 = 0.18 μM.	31103901
MDCK	Antiviral assay		3 days	Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) infected in MDCK cells after 3 days by MTT assay, EC50 = 0.4 μM.	31103901
Vero	Antiviral assay		24 hrs	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr, IC50 = 0.24 μM.	ChEMBL
MIAPaCa2	Cytotoxicity assay		48 hrs	Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTS assay, CC50 = 6.5 μM.	ChEMBL
BT474	Cytotoxicity assay		48 hrs	Cytotoxicity against human BT474 cells after 48 hrs by MTS assay, CC50 = 14 μM.	ChEMBL
BT474	Function assay	7.5 uM	3 days	Disruption of preformed spheroids in human BT474 cancer stem cells at 7.5 uM after 3 days by microscopic analysis	ChEMBL
DU145	Function assay	7.5 uM	3 days	Disruption of preformed spheroids in human DU145 cancer stem cells at 7.5 uM after 3 days by microscopic analysis	ChEMBL
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Informazioni chimiche, conservazione e stabilità

Peso molecolare	751.00	Formula	C₄₂H₇₀O₁₁	Conservazione (Dalla data di ricezione)	3 anni-20°Cpolvere
N. CAS	53003-10-4	Scarica SDF		Conservazione delle soluzioni stock	1 anno-80°Cin solvente 1 mese-20°Cin solvente
Sinonimi	Procoxacin			Smiles	CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O

Solubilità

In vitro
Lotto:

DMSO : 100 mg/mL (133.15 mM)
(Il DMSO contaminato da umidità può ridurre la solubilità. Utilizzare DMSO fresco e anidro.)

Ethanol : 100 mg/mL

Water : Insoluble

Calcolatore di Molarità

Massa	Concentrazione	Volume	Peso molecolare
=	×	×

Calcolatore di Diluizione Calcolatore del Peso Molecolare

In vivo Lotto:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validato dai laboratori Selleck. Se necessiti di modifiche a questa formulazione, contatta il nostro team di vendita per test personalizzati.	5.000mg/ml (6.66mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validato dai laboratori Selleck. Se necessiti di modifiche a questa formulazione, contatta il nostro team di vendita per test personalizzati.	2.500mg/ml (3.33mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validato dai laboratori Selleck. Se necessiti di modifiche a questa formulazione, contatta il nostro team di vendita per test personalizzati.	2.500mg/ml (3.33mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

Calcolatore di formulazione in vivo (Soluzione chiara)

Passo 1: Inserire le informazioni di seguito (Consigliato: Un animale aggiuntivo per tenere conto della perdita durante lesperimento)

Dosaggio: mg/kg Peso medio degli animali: g Volume di dosaggio per animale:μL Numero di animali:

Passo 2: Inserire la formulazione in vivo (Questo è solo il calcolatore, non la formulazione. Contattateci prima se non cè una formulazione in vivo nella sezione Solubilità.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Risultati del calcolo:

Concentrazione di lavoro: mg/ml;

Metodo per preparare il liquido master di DMSO: mg farmaco predissolto in μL DMSO ( Concentrazione del liquido master mg/mL, Vi preghiamo di contattarci prima se la concentrazione supera la solubilità del DMSO del lotto del farmaco. )

Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungereμL PEG300, mescolare e chiarire, quindi aggiungereμL Tween 80, mescolare e chiarire, quindi aggiungere μL ddH₂O, mescolare e chiarire.

Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungere μL Olio di mais, mescolare e chiarire.

Nota: 1. Si prega di assicurarsi che il liquido sia limpido prima di aggiungere il solvente successivo.
2. Assicurarsi di aggiungere il/i solvente/i in ordine. È necessario assicurarsi che la soluzione ottenuta, nellaggiunta precedente, sia una soluzione limpida prima di procedere allaggiunta del solvente successivo. Metodi fisici come il vortex, gli ultrasuoni o il bagno dacqua calda possono essere utilizzati per facilitare la dissoluzione.

Meccanismo dazione

Targets/IC₅₀/Ki	Wnt/β-catenin
In vitro	La salinomicina, un antibiotico ionoforo polietere isolato da Streptomyces albus, ha dimostrato di uccidere le CSC in diversi tipi di tumori umani, molto probabilmente interferendo con i trasportatori di farmaci ABC (ATP-binding cassette), la via di segnalazione Wnt/β-catenina e altre vie delle CSC. Esibisce attività antimicrobica contro batteri Gram-positivi tra cui Bacillus subtilis, Staphylococcus aureus, Micrococcus flavus, Sarcina lutea, Mycobacterium spp., alcuni funghi filamentosi, Plasmodium falciparum ed Eimeria spp., parassiti protozoari responsabili della coccidiosi, una malattia del pollame. Inoltre, questo composto ha dimostrato precocemente di agire in diverse membrane biologiche, comprese le membrane citoplasmatiche e mitocondriali, come ionoforo di cationi monovalenti con stretta selettività per gli ioni alcalini e una forte preferenza per il K+, promuovendo così l'efflusso mitocondriale e citoplasmatico di K+ e inibendo la fosforilazione ossidativa. La salinomicina può indurre una massiccia apoptosi nelle cellule tumorali umane di diversa origine che mostrano molteplici meccanismi di resistenza ai farmaci e all'apoptosi.
In vivo	Salinomycin (from Streptomyces albus) è in grado di eliminare efficacemente le CSC e di indurre una regressione clinica parziale di tumori pesantemente pretrattati e resistenti alla terapia. È stato anche dimostrato come un agente inotropo e cronotropo positivo che ha aumentato la gittata cardiaca, la pressione sistolica ventricolare sinistra, la frequenza cardiaca, la pressione arteriosa media, la vasodilatazione e il flusso sanguigno delle arterie coronarie e la concentrazione di catecolamine plasmatiche. Questi risultati sono stati ottenuti in esperimenti con cani meticci che avevano ricevuto una singola iniezione endovenosa di 150 µg/kg di questo composto. Tuttavia, è stata riportata una considerevole tossicità della salinomicina nei mammiferi, come cavalli, maiali, gatti e alpaca, dopo assunzione orale o inalatoria accidentale. I dati di valutazione del rischio recentemente pubblicati dall'Autorità europea per la sicurezza alimentare dichiarano una dose giornaliera accettabile (DGA) di 5 µg/kg di salinomicina per gli esseri umani, perché l'assunzione giornaliera di più di 500 µg/kg di salinomicina da parte dei cani porta a effetti neurotossici, come perdita di mielina e degenerazione assonale. La somministrazione endovenosa di 200-250 µg/kg di salinomicina ogni due giorni per tre settimane si traduce in una regressione parziale delle metastasi tumorali e mostra solo effetti collaterali acuti e a lungo termine minori, ma nessun effetto collaterale grave acuto e a lungo termine osservato con i farmaci chemioterapici convenzionali.
Riferimenti	[1] https://pubmed.ncbi.nlm.nih.gov/23251084/ [2] https://pubmed.ncbi.nlm.nih.gov/23028492/ [3] https://pubmed.ncbi.nlm.nih.gov/23338561/

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