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Etoposide inibitore della Topoisomerase II
N. Cat.S1225
Struttura chimica
Peso molecolare: 588.56
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| Target correlati | HDAC PARP ATM/ATR DNA-PK WRN DNA/RNA Synthesis Topoisomerase PPAR Sirtuin Casein Kinase |
|---|---|
| Altro Antineoplastic and Immunosuppressive Antibiotics Inibitori | Staurosporine (STS) Cyclosporin A Oligomycin A (MCH 32) Puromycin Dihydrochloride Nigericin sodium salt Geldanamycin (NSC 122750) Honokiol Streptozotocin (STZ) Sodium Monensin (NSC 343257) Cephalomannine |
Coltura cellulare, trattamento e concentrazione di lavoro
| Linee cellulari | Tipo di saggio | Concentrazione | Tempo di incubazione | Formulazione | Descrizione dellattività | PMID |
|---|---|---|---|---|---|---|
| Kelly | Growth Inhibition Assay | IC50=0.12 ± 0.01 μM | 25960282 | |||
| KellyCis83 | Growth Inhibition Assay | IC50=0.16 ± 0.02 μM | 25960282 | |||
| SK-N-AS | Growth Inhibition Assay | IC50=0.24 ± 0.03 μM | 25960282 | |||
| SK-N-ASCis24 | Growth Inhibition Assay | IC50=0.57 ± 0.11 μM | 25960282 | |||
| U87 | Growth Inhibition Assay | 0-50 μM | 48 h | decreases cell viability which can be enhanced by silibinin | 25750273 | |
| HCT116 | Growth Inhibition Assay | 0.5-2.5 μM | 48 h | IC50=1.73 ± 0.21 μM | 25746763 | |
| HT-29 | Growth Inhibition Assay | 0.5-2.5 μM | 48 h | IC50=7.2 ± 1.04 μM | 25746763 | |
| Caco2 | Growth Inhibition Assay | 0.5-2.5 μM | 48 h | IC50=7.26 ± 1.68 μM | 25746763 | |
| COLO 205 | Growth Inhibition Assay | 0.5-2.5 μM | 48 h | IC50=1.61 ± 0.02 μM | 25746763 | |
| SW480 | Growth Inhibition Assay | 0.5-2.5 μM | 48 h | IC50=4.92 ± 0.33 μM | 25746763 | |
| HEK293T | Growth Inhibition Assay | 1-5 μM | 48 h | IC50=2.42 ± 0.05 μM | 25746763 | |
| Hep3B | Function Assay | 10 μM | 48 h | reduces the enhancing effect of BMP-6 | 25633564 | |
| Hep3B | Function Assay | 0.1-10 μM | 24 h | suppresses the expression of hepcidin mRNA | 25633564 | |
| HEK293 | Growth Inhibition Assay | IC50=7.14 ± 0.36 μM | 25603122 | |||
| DU145 | Growth Inhibition Assay | IC50=2.28 ± 0.04 μM | 25603122 | |||
| HCT15 | Growth Inhibition Assay | IC50=0.81 ± 0.01 μM | 25603122 | |||
| T47D | Growth Inhibition Assay | IC50=3.18 ± 0.11 μM | 25603122 | |||
| SMMC-7721 | Function Assay | 40 μM | 48 h | DMSO | induces γH2AX foci formation | 25544361 |
| MDA-MB-231 | Growth Inhibition Assay | 72 h | IC50=21.2 ± 4.2 μM | 25486219 | ||
| MCF-7 | Growth Inhibition Assay | 72 h | IC50=10.9 ± 2.1 μM | 25486219 | ||
| Jurkat | Growth Inhibition Assay | 72 h | IC50=1.2 ± 1.5 μM | 25486219 | ||
| HeLa | Growth Inhibition Assay | 72 h | IC50=3.9 ± 2.3 μM | 25486219 | ||
| MCF7 | Growth Inhibition Assay | 5-100 μM | 7 d | inhibits cell growth in a dose-dependent manner | 25472619 | |
| K562 | Growth Inhibition Assay | 72 h | IC50=0.29 μM | 25282653 | ||
| K/VP.5 | Growth Inhibition Assay | 72 h | IC50=4.9 μM | 25282653 | ||
| SH-EP | Function Assay | 20 μg/ml | 24 h | increases the expression of endogenous DEPP | 25261981 | |
| SCC25 | Growth Inhibition Assay | 24 h | IC50=43.3 ± 1.12 μM | 25220729 | ||
| CAL27 | Growth Inhibition Assay | 24 h | IC50=52.1 ± 1.09 μM | 25220729 | ||
| FaDu | Growth Inhibition Assay | 24 h | IC50=25.89 ± 1.13 μM | 25220729 | ||
| SCC25 | Growth Inhibition Assay | 48 h | IC50=20.86 ± 1.07 μM | 25220729 | ||
| CAL27 | Growth Inhibition Assay | 48 h | IC50=18.24 ± 1.15 μM | 25220729 | ||
| FaDu | Growth Inhibition Assay | 48 h | IC50=6.43 ± 1.13 μM | 25220729 | ||
| SCC25 | Growth Inhibition Assay | 72 h | IC50=8.41 ± 1.11 μM | 25220729 | ||
| CAL27 | Growth Inhibition Assay | 72 h | IC50=4.27 ± 1.14 μM | 25220729 | ||
| FaDu | Growth Inhibition Assay | 72 h | IC50=5.02 ± 1.15 μM | 25220729 | ||
| MCF-7 | Growth Inhibition Assay | 48 h | DMSO | IC50=7.2 ± 0.8 μM | 25216378 | |
| T-47D | Growth Inhibition Assay | 48 h | DMSO | IC50=7.7 ± 0.7 μM | 25216378 | |
| MDA-MB-231 | Growth Inhibition Assay | 48 h | DMSO | IC50=12.8 ± 1.0 μM | 25216378 | |
| DU145 | Apoptosis Assay | 10-100 μM | 8 h | DMSO | induces cell death significantly in a very low concentration | 25149681 |
| DU145 stem-like | Apoptosis Assay | 10-100 μM | 8 h | DMSO | induces cell death in a dose-dependent manner | 25149681 |
| DU145 | Function Assay | 10-100 μM | 2 h | DMSO | increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner | 25149681 |
| DU145 stem-like | Function Assay | 10-100 μM | 2 h | DMSO | increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner | 25149681 |
| UW228-3 | Growth Inhibition Assay | 0.01-300 μM | 48 h | DMSO | IC50=0.99 μM | 25119185 |
| NSCs | Growth Inhibition Assay | 0.01-300 μM | 48 h | DMSO | IC50=0.3-3 μM | 25119185 |
| MKL-1 | Function Assay | 10-1000 nM | 4 d | induces the induction of MHC-I expression | 25116754 | |
| MCF7 EV | Function Assay | 10-100 μM | 2 h | induces production of γH2AX | 25088203 | |
| MCF 7BMI1 | Function Assay | 10-100 μM | 2 h | induces production of γH2AX | 25088203 | |
| MCF7 EV | Function Assay | 10-100 μM | 2 h | ETOP induces ATM activation | 25088203 | |
| MCF7 BMI1 | Function Assay | 10-100 μM | 2 h | ETOP induces ATM activation | 25088203 | |
| HepG2 | Growth Inhibition Assay | DMSO | IC50=30.16 ± 0.50 μM | 25078311 | ||
| MOLT-3 | Growth Inhibition Assay | DMSO | IC50=0.051 ± 0.002 μM | 25078311 | ||
| HT1080 | Growth Inhibition Assay | 1-100 μM | 4/24/48 h | DMSO | induces cell death significantly in a very low concentration | 25078064 |
| HT1080 | Function Assay | 0.0001-100 μM | 1-24 h | DMSO | induces p-p53(ser15) in both time- and concentration-dependent manner | 25078064 |
| HT1080 | Growth Inhibition Assay | 0.0001-100 μM | 24 h | DMSO | causes an increase in the number of cells in G2/M, while decreasing S and G1 phase cells | 25078064 |
| HD-MY-Z | Growth Inhibition Assay | 24/48/72 h | IC50＞100 μM | 25048236 | ||
| DOHH-2 | Growth Inhibition Assay | 24 h | IC50＞100 μM | 25048236 | ||
| DOHH-2 | Growth Inhibition Assay | 48 h | IC50=19.9 μM | 25048236 | ||
| DOHH-2 | Growth Inhibition Assay | 72 h | IC50=5 μM | 25048236 | ||
| REH | Growth Inhibition Assay | 24 h | IC50=0.027 μM | 25048236 | ||
| REH | Growth Inhibition Assay | 48 h | IC50=0.014 μM | 25048236 | ||
| REH | Growth Inhibition Assay | 72 h | IC50=0.015 μM | 25048236 | ||
| HH | Growth Inhibition Assay | 24 h | IC50=104.7 μM | 25048236 | ||
| HH | Growth Inhibition Assay | 48 h | IC50=48.6 μM | 25048236 | ||
| HH | Growth Inhibition Assay | 72 h | IC50=14.7 μM | 25048236 | ||
| HuT-78 | Growth Inhibition Assay | 24 h | IC50=9.3 μM | 25048236 | ||
| HuT-78 | Growth Inhibition Assay | 48 h | IC50=4.3 μM | 25048236 | ||
| HuT-78 | Growth Inhibition Assay | 72 h | IC50=4.2 μM | 25048236 | ||
| OPM-2 | Growth Inhibition Assay | 24 h | IC50=24.1 μM | 25048236 | ||
| OPM-2 | Growth Inhibition Assay | 48 h | IC50=4 μM | 25048236 | ||
| OPM-2 | Growth Inhibition Assay | 72 h | IC50=1.3 μM | 25048236 | ||
| RPMI-8226 | Growth Inhibition Assay | 24 h | IC50=106.6 μM | 25048236 | ||
| RPMI-8226 | Growth Inhibition Assay | 48 h | IC50=91.1 μM | 25048236 | ||
| RPMI-8226 | Growth Inhibition Assay | 72 h | IC50=14.9 μM | 25048236 | ||
| U-266 | Growth Inhibition Assay | 24 h | IC50=86.2 μM | 25048236 | ||
| U-266 | Growth Inhibition Assay | 48 h | IC50=68.4 μM | 25048236 | ||
| U-266 | Growth Inhibition Assay | 72 h | IC50=27.4 μM | 25048236 | ||
| Kelly | Growth Inhibition Assay | 0-10 μM | 72 h | IC50=1.518 μM | 25008900 | |
| SH-SY5Y | Growth Inhibition Assay | 0-10 μM | 72 h | IC50=0.754 μM | 25008900 | |
| SK-N-AS | Growth Inhibition Assay | 0-10 μM | 72 h | IC50=1.712 μM | 25008900 | |
| SK-N-DZ | Growth Inhibition Assay | 0-10 μM | 72 h | IC50=5.485 μM | 25008900 | |
| HepG2 | Growth Inhibition Assay | 48 h | DMSO | IC50=13.65 ± 0.92 μM | 24996136 | |
| A549 | Growth Inhibition Assay | 48 h | DMSO | IC50=241.9 ± 31.23 μM | 24996136 | |
| MCF7 | Growth Inhibition Assay | 48 h | DMSO | IC50=81.09 ± 14.21 μM | 24996136 | |
| HL-60 | Growth Inhibition Assay | 72 h | IC50=0.12 μM | 24993014 | ||
| HL-60[R] | Growth Inhibition Assay | 72 h | IC50=3.12 μM | 24993014 | ||
| MIAPACA | Growth Inhibition Assay | GI50=1.3 ± 0.03 μM | 24953821 | |||
| MCF-7 | Growth Inhibition Assay | GI50=0.25 ± 0.1 μM | 24953821 | |||
| HeLa | Growth Inhibition Assay | GI50=0.64 ± 0.4 μM | 24953821 | |||
| MO59K | Growth Inhibition Assay | 7 d | IC50=0.17 μM | 24953561 | ||
| MO59J | Growth Inhibition Assay | 7 d | IC50=0.1 μM | 24953561 | ||
| ME 180 | Growth Inhibition Assay | 48 h | IC50=8.9 ± 0.3 μM | 24953027 | ||
| MCF-7 | Growth Inhibition Assay | 48 h | IC50=23.9 ± 0.3 μM | 24953027 | ||
| HeLa | Growth Inhibition Assay | 48 h | IC50=4.71 ± 1.4 μM | 24953027 | ||
| MDA-MB-453 | Growth Inhibition Assay | 48 h | IC50=12.5 ± 0.85 μM | 24953027 | ||
| MDA-MB-231 | Growth Inhibition Assay | 48 h | IC50=24.22 ± 2.94 μM | 24953027 | ||
| PC-3 | Growth Inhibition Assay | 48 h | IC50=14.4 ± 3.23 μM | 24953027 | ||
| HT-29 | Growth Inhibition Assay | 48 h | IC50=21.45 ± 3.87 μM | 24953027 | ||
| BGC-823 | Growth Inhibition Assay | 48 h | IC50=43.74 ± 5.13 μM | 24793877 | ||
| HeLa | Growth Inhibition Assay | 48 h | IC50=209.90 ± 13.42 μM | 24793877 | ||
| A549 | Growth Inhibition Assay | 48 h | IC50=139.54 ± 7.05 μM | 24793877 | ||
| HK-2 | Growth Inhibition Assay | 48 h | IC50=9.17 ± 1.58 μM | 24793877 | ||
| KB | Cytotoxicity assay | 3 days | Cytotoxicity against human KB cells assessed as reduction in cell number after 3 days, ID50 = 0.2 μM. | 1331331 | ||
| KB | Cytotoxicity assay | 3 days | In vitro cytotoxicity against KB cells after a 3-day incubation., ID50 = 0.2 μM. | 2158562 | ||
| HCT116 | Cytotoxicity assay | Cytotoxicity against HCT116 cells., IC50 = 2.5 μM. | 7473578 | |||
| CCRF CEM | Function assay | Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells, IC50 = 0.002 μM. | 7932571 | |||
| KB ATCC | Function assay | 50% reduction in the number of KB ATCC cells, ID50 = 0.32 μM. | 8120864 | |||
| KB | Cytotoxicity assay | 3 days | Cytotoxicity against KB cells after a 3 day incubation, ID50 = 0.2 μM. | 8120864 | ||
| SCLC | Cytotoxicity assay | Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP), IC50 = 1.3 μM. | 8258835 | |||
| P388 | Cytotoxicity assay | 1 hr | In vitro cytotoxicity against P388 murine leukemia cells in culture in a clonogenic assay after 1 hour exposure to drug, IC50 = 0.3 μM. | 8410993 | ||
| HeLa | Function assay | Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assay, EC50 = 0.81 μM. | 8410993 | |||
| Bel7402 | Cytotoxicity assay | 5 days | Cytotoxicity against human Bel7402 cells after 5 days by MTT assay, IC50 = 1.9 μM. | 8778240 | ||
| BGC | Cytotoxicity assay | 5 days | Cytotoxicity against human BGC cells after 5 days by MTT assay, IC50 = 6.7 μM. | 8778240 | ||
| HCT8 | Cytotoxicity assay | 5 days | Cytotoxicity against human HCT8 cells after 5 days by MTT assay, IC50 = 6.4 μM. | 8778240 | ||
| HL60 | Cytotoxicity assay | 5 days | Cytotoxicity against human HL60 cells after 5 days by MTT assay, IC50 = 0.16 μM. | 8778240 | ||
| C6 | Cytotoxicity assay | 3 days | Cytotoxicity against rat C6 cells after 3 days treated 4 hrs before db-cAMP challenge by MTT assay, LC50 = 0.12 μM. | 8988604 | ||
| KB | Growth inhibition assay | Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50 = 0.1 μM. | 9767632 | |||
| MT-4 | Growth inhibition assay | Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50 = 0.08 μM. | 9767632 | |||
| L1210 | Cytotoxicity assay | In vitro cytotoxic activity against murine L1210 leukemia cells., IC50 = 0.2 μM. | 9804687 | |||
| HL-60 | Cytotoxicity assay | Relative cytotoxicity against human promyelocytic leukemia(HL-60) cells, IC50 = 0.367 μM. | 10377219 | |||
| HL-60 | Cytotoxicity assay | Relative cytotoxicity against human promyelocytic leukemia(HL-60) cells, IC90 = 0.73 μM. | 10377219 | |||
| HL-60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.025 μM. | 11170674 | ||
| A549 | Function assay | GI values against A549 cells (lung cancer), GI50 = 6.30957 μM. | 11311065 | |||
| CAKI-1 | Function assay | GI values against CAKI-1 cells(renal carcinoma), GI50 = 6.30957 μM. | 11311065 | |||
| KB | Function assay | GI values against KB cells (nasopharyngeal carcinoma), GI50 = 0.19953 μM. | 11311065 | |||
| HEL | Function assay | Inhibitory activity against human cytomegalovirus (HCMV) in HEL cells, ED50 = 8.64 μM. | 11311065 | |||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by MTT assay, IC50 = 0.5 μM. | 11473438 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by MTT assay, IC50 = 5.4 μM. | 11473438 | |||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 12.3 μM. | 11473438 | |||
| P388 | Cytotoxicity assay | Cytotoxicity against mouse P388 cells by MTT assay, IC50 = 0.1 μM. | 11473438 | |||
| HT-29 | Cytotoxicity assay | Tested for cytotoxicity against Colon carcinoma type HT-29 cell line expressing MDR-1 (-) gene; 35% of cells were affected, IC50 = 10 μM. | 11844671 | |||
| KB | Function assay | Compound concentration required to reduce the cell proliferation of Wild type and Drug- resistant human nasopharyngeal carcinoma KB cells by 50%, IC50 = 0.6 μM. | 12431048 | |||
| P388 | Growth inhibition assay | Growth inhibitory activity against murine P388 leukemia cells, IC50 = 0.15 μM. | 12620081 | |||
| HL60 | Apoptosis assay | In vitro concentration required to induce apoptosis in HL60 cells, AC50 = 0.45 μM. | 12877593 | |||
| HL60R | Apoptosis assay | In vitro concentration required to induce apoptosis in HL60R cells, AC50 = 15 μM. | 12877593 | |||
| HL60 | Function assay | In vitro inhibitory concentration against proliferation of HL60 cells, IC50 = 0.123 μM. | 12877593 | |||
| HL60R | Function assay | In vitro inhibitory concentration against proliferation of HL60R cells, IC50 = 6.5 μM. | 12877593 | |||
| HL60R | Function assay | In vitro inhibitory concentration against proliferation of HL60R cells along with 5 (uM) verapamil, IC50 = 0.5 μM. | 12877593 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by MTT assay, IC50 = 0.2 μM. | 14738377 | |||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay, IC50 = 2.3 μM. | 14738395 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by methylene blue assay, IC50 = 1.1 μM. | 14738395 | ||
| KB | Cytotoxicity assay | Cytotoxicity against human KB cells, ID50 = 0.2 μM. | 14987069 | |||
| KB | Cytotoxicity assay | Cytotoxicity against human KB cells, LD50 = 3 μM. | 14987069 | |||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells, GI50 = 4.36516 μM. | 14987069 | |||
| MOLT4 | Cytotoxicity assay | Cytotoxicity against human MOLT4 cells, GI50 = 1.02329 μM. | 14987069 | |||
| HeLa | Function assay | Concentration required to inhibit S phase and G2/M phase in HeLa cells, Concentration = 2 μM. | 15026047 | |||
| HeLa | Growth inhibition assay | Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay, GI50 = 40 μM. | 15026047 | |||
| KB | Function assay | 3 days | Dose required for reduction in camptothecin resistant human nasopharyngeal KB cancer cells after 3 days incubation, ED50 = 7 μM. | 15456257 | ||
| KB-7d | Function assay | 3 days | Dose required for reduction in etoposide resistant human nasopharyngeal KB-7d cancer cells after 3 days incubation, ED50 = 17.2 μM. | 15456257 | ||
| A549 | Function assay | 3 days | Dose required for reduction in human lung A549 cancer cells after 3 days incubation, ED50 = 10.6 μM. | 15456257 | ||
| KB | Function assay | 3 days | Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation, ED50 = 0.3 μM. | 15456257 | ||
| 1A9 | Function assay | 3 days | Dose required to cause reduction in human ovarian 1A9 cancer cells after 3 days incubation, ED50 = 0.15 μM. | 15456257 | ||
| HSC2 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HSC2 cells assessed as cell viability after 24 hrs, IC50 = 41 μM. | 15620262 | ||
| A549 | Function assay | Effective dose on human lung carcinoma (A549) cells, ED50 = 3.39 μM. | 15914002 | |||
| HL60 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HL60 cells after 24 hrs by MTT assay, IC50 = 25 μM. | 15974617 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, IC50 = 0.8775 μM. | 16309315 | ||
| TK10 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human TK10 cells after 48 hrs by SRB assay, IC50 = 9.9525 μM. | 16309315 | ||
| UACC62 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay, IC50 = 1.13 μM. | 16309315 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, ED50 = 3.76 μM. | 16441087 | ||
| HeLa | Antiproliferative assay | 69 hrs | Antiproliferative effect against human HeLa cells after 69 hrs by MTT assay, IC50 = 3.6 μM. | 16499324 | ||
| HL60 | Antiproliferative assay | 69 hrs | Antiproliferative effect against human HL60 cells after 69 hrs, IC50 = 0.21 μM. | 16499324 | ||
| MCF7 | Antiproliferative assay | 72 hrs | Antiproliferative effect against human MCF7 cells after 72 hrs by MTT assay, IC50 = 0.19 μM. | 16499324 | ||
| K-562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K-562 cells after 72 hrs by MTT assay, IC50 = 1.87 μM. | 16872135 | ||
| LAMA-84 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human LAMA-84 cells after 72 hrs by MTT assay, IC50 = 0.79 μM. | 16872135 | ||
| SKW3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKW3 cells after 72 hrs by MTT assay, IC50 = 0.82 μM. | 16872135 | ||
| HL-60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay, IC50 = 10.5 μM. | 16933865 | ||
| HSC2 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HSC2 cells after 24 hrs by MTT assay, IC50 = 24 μM. | 17125230 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs, IC50 = 2 μM. | 17125231 | ||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by SRB assay, IC50 = 1.16 μM. | 17194596 | |||
| HCT116 | Cytotoxicity assay | Cytotoxicity against human HCT116 cells by SRB assay, IC50 = 1.87 μM. | 17194596 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by SRB assay, IC50 = 0.37 μM. | 17194596 | |||
| HT1080 | Cytotoxicity assay | Cytotoxicity against human HT1080 cells by SRB assay, IC50 = 0.25 μM. | 17194596 | |||
| SK-MEL-2 | Cytotoxicity assay | Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50 = 5.72 μM. | 17194596 | |||
| SK-OV-3 | Cytotoxicity assay | Cytotoxicity against human SK-OV-3 cells by SRB assay, IC50 = 4.28 μM. | 17194596 | |||
| SNU638 | Cytotoxicity assay | Cytotoxicity against human SNU638 cells by SRB assay, IC50 = 0.23 μM. | 17194596 | |||
| XF498 | Cytotoxicity assay | Cytotoxicity against human XF498 cells by SRB assay, IC50 = 3.48 μM. | 17194596 | |||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxic activity against human MCF7 cells after 48 hrs by MTT reduction assay, IC50 = 3.2 μM. | 17316916 | ||
| HCT116 | Cytotoxicity assay | Cytotoxicity against human HCT116 cells by XTT assay, IC50 = 1.7 μM. | 17368022 | |||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells by XTT assay, IC50 = 35.6 μM. | 17368022 | |||
| MDA-MB468 | Cytotoxicity assay | Cytotoxicity against human MDA-MB468 cells by XTT assay, IC50 = 13.6 μM. | 17368022 | |||
| K562 | Growth inhibition assay | 5 days | Growth inhibition of K562 cells by XTT assay after 5 days, IC50 = 0.32 μM. | 17411092 | ||
| mouse astrocyte cells | Antiproliferative assay | Antiproliferative activity against mouse astrocyte cells by MTT assay, EC50 = 0.433 μM. | 17417631 | |||
| mouse medulloblastoma cells | Antiproliferative assay | Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay, EC50 = 0.208 μM. | 17417631 | |||
| mouse neural precursor cells | Antiproliferative assay | Antiproliferative activity against mouse neural precursor cells by MTT assay, EC50 = 0.34 μM. | 17417631 | |||
| BV173 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human BV173 cells after 72 hrs by MTT assay, IC50 = 0.9 μM. | 17459529 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50 = 3.1 μM. | 17459529 | ||
| H460 | Growth inhibition assay | Growth inhibition of human H460 cells by MTT assay, IC50 = 0.2 μM. | 17482821 | |||
| HeLa | Growth inhibition assay | Growth inhibition of human HeLa cells by MTT assay, IC50 = 2.9 μM. | 17482821 | |||
| MiaPaCa2 | Growth inhibition assay | Growth inhibition of human MiaPaCa2 cells by MTT assay, IC50 = 15.4 μM. | 17482821 | |||
| SW620 | Growth inhibition assay | Growth inhibition of human SW620 cells by MTT assay, IC50 = 20 μM. | 17482821 | |||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by SRB method, IC50 = 0.32 μM. | 17493824 | ||
| HCT15 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT15 cells after 48 hrs by SRB method, IC50 = 2.43 μM. | 17493824 | ||
| SK-MEL-2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB method, IC50 = 0.3 μM. | 17493824 | ||
| SKOV3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SKOV3 cells after 48 hrs by SRB method, IC50 = 1.72 μM. | 17493824 | ||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by SRB microtiter plate assay, IC50 = 1.4 μM. | 17585747 | |||
| DU145 | Cytotoxicity assay | Cytotoxicity against human DU145 cells by SRB microtiter plate assay, IC50 = 2.4 μM. | 17585747 | |||
| KB | Cytotoxicity assay | Cytotoxicity against human KB cells by SRB microtiter plate assay, IC50 = 4.8 μM. | 17585747 | |||
| ZR751 | Cytotoxicity assay | Cytotoxicity against human ZR751cells by SRB microtiter plate assay, IC50 = 3.1 μM. | 17585747 | |||
| HL20 | Growth inhibition assay | 48 hrs | Inhibition of cell growth in human HL20 cells after 48 hrs by MTT assay, IC50 = 0.315 μM. | 17889547 | ||
| HeLa | Growth inhibition assay | 48 hrs | Growth inhibition of HeLa cells after 48 hrs by MTT assay, GI50 = 8 μM. | 17894480 | ||
| HeLa | Antitumor assay | 72 hrs | Antitumor activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 3 μM. | 17935309 | ||
| MiaPaCa2 | Antitumor assay | 72 hrs | Antitumor activity against human MiaPaCa2 cells after 72 hrs by MTT assay, IC50 = 15 μM. | 17935309 | ||
| SW620 | Antitumor assay | 72 hrs | Antitumor activity against human SW620 cells after 72 hrs by MTT assay, IC50 = 20 μM. | 17935309 | ||
| HL60/MX2 | Cytotoxicity assay | Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay, GI50 = 5.98 μM. | 17962028 | |||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, GI50 = 0.14 μM. | 17962028 | ||
| 502713 | Cytotoxicity assay | Cytotoxicity against human 502713 cells by sulforhodamine B assay, IC50 = 2.42 μM. | 17988764 | |||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by sulforhodamine B assay, IC50 = 5.62 μM. | 17988764 | |||
| DU145 | Cytotoxicity assay | Cytotoxicity against human DU145 cells by sulforhodamine B assay, IC50 = 3.85 μM. | 17988764 | |||
| HCT-15 | Cytotoxicity assay | Cytotoxicity against human HCT-15 cells by sulforhodamine B assay, IC50 = 1.48 μM. | 17988764 | |||
| HEP2 | Cytotoxicity assay | Cytotoxicity against human HEP2 cells by sulforhodamine B assay, IC50 = 2.15 μM. | 17988764 | |||
| PC-3 | Cytotoxicity assay | Cytotoxicity against human PC-3 cells by sulforhodamine B assay, IC50 = 17.4 μM. | 17988764 | |||
| SF295 | Cytotoxicity assay | Cytotoxicity against human SF295 cells by sulforhodamine B assay, IC50 = 13.3 μM. | 17988764 | |||
| K562 | Cytotoxicity assay | 5 days | Cytotoxicity against human K562 cells after 5 days by XTT assay, IC50 = 0.32 μM. | 18076140 | ||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells by XTT assay, IC50 = 35.6 μM. | 18093835 | |||
| DU145 | Cytotoxicity assay | Cytotoxicity against human DU145 cells, IC50 = 29.79 μM. | 18178085 | |||
| HCT116 | Cytotoxicity assay | Cytotoxicity against human HCT116 cells, IC50 = 15.11 μM. | 18178085 | |||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells, IC50 = 18.24 μM. | 18178085 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells, IC50 = 1.44 μM. | 18178085 | |||
| MDA-MB-231 | Cytotoxicity assay | Cytotoxicity against human MDA-MB-231 cells, IC50 = 16.25 μM. | 18178085 | |||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.9 μM. | 18258438 | ||
| AGS | Antitumor assay | 72 hrs | Antitumor against human AGS cells after 72 hrs by MTT assay, IC50 = 0.36 μM. | 18299197 | ||
| HL60 | Antitumor assay | 72 hrs | Antitumor against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.8 μM. | 18299197 | ||
| J82 | Antitumor assay | 72 hrs | Antitumor against human J82 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. | 18299197 | ||
| SK-MES1 | Antitumor assay | 72 hrs | Antitumor against human SK-MES1 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. | 18299197 | ||
| MRC5 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50 = 3.9 μM. | 18299197 | ||
| H520 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human H520 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay, GI50 = 8.7 μM. | 18321710 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by Cell Titer 96 Aqueous Non-Radioactive assay, GI50 = 11.1 μM. | 18321710 | ||
| A549 | Cytotoxicity assay | 3 days | Cytotoxicity against human A549 cells after 3 days by SRB assay, IC50 = 1.16 μM. | 18321715 | ||
| HCT15 | Cytotoxicity assay | 3 days | Cytotoxicity against human HCT15 cells after 3 days by SRB assay, IC50 = 2.8 μM. | 18321715 | ||
| HL60 | Cytotoxicity assay | 3 days | Cytotoxicity against human HL60 cells after 3 days by SRB assay, IC50 = 0.37 μM. | 18321715 | ||
| HT1080 | Cytotoxicity assay | 3 days | Cytotoxicity against human HT1080 cells after 3 days by SRB assay, IC50 = 0.25 μM. | 18321715 | ||
| SK-MEL-2 | Cytotoxicity assay | 3 days | Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay, IC50 = 5.72 μM. | 18321715 | ||
| SKOV3 | Cytotoxicity assay | 3 days | Cytotoxicity against human SKOV3 cells after 3 days by SRB assay, IC50 = 4.28 μM. | 18321715 | ||
| SNU638 | Cytotoxicity assay | 3 days | Cytotoxicity against human SNU638 cells after 3 days by SRB assay, IC50 = 0.23 μM. | 18321715 | ||
| XF498 | Cytotoxicity assay | 3 days | Cytotoxicity against human XF498 cells after 3 days by SRB assay, IC50 = 3.48 μM. | 18321715 | ||
| HL60 | Apoptosis assay | 48 hrs | Induction of apoptosis in human HL60 cells after 48 hrs, AC50 = 0.4 μM. | 18339455 | ||
| 5637 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human 5637 cells after 96 hrs by crystal violet assay, IC50 = 0.54 μM. | 18434163 | ||
| A427 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human A427 cells after 96 hrs by crystal violet assay, IC50 = 0.13 μM. | 18434163 | ||
| KYSE70 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human KYSE70 cells after 96 hrs by crystal violet assay, IC50 = 0.94 μM. | 18434163 | ||
| MCF7 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human MCF7 cells after 96 hrs by crystal violet assay, IC50 = 0.5 μM. | 18434163 | ||
| NCI-H520 | Growth inhibition assay | Growth inhibition of human NCI-H520 cells, GI50 = 13.5 μM. | 18502124 | |||
| PC3 | Growth inhibition assay | Growth inhibition of human PC3 cells, GI50 = 12.5 μM. | 18502124 | |||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human mitoxantrone-sensitive HL60 cells after 72 hrs, IC50 = 0.486 μM. | 18507368 | ||
| HL60/MX2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mitoxantrone-resistant human HL60/MX2 cells after 72 hrs, IC50 = 48.5 μM. | 18507368 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.2 μM. | 18507472 | ||
| HL60 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.315 μM. | 18513974 | ||
| K562 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, IC50 = 1.27 μM. | 18514972 | ||
| KB | Antiproliferative assay | 48 hrs | Antiproliferative activity against human KB cells after 48 hrs by MTT assay, IC50 = 0.42 μM. | 18514972 | ||
| L02 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human L02 cells after 48 hrs by MTT assay, IC50 = 13 μM. | 18514972 | ||
| DU145 ATCC HTB 81 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human DU145 ATCC HTB 81 cells after 72 hrs by MTT assay, IC50 = 1.5 μM. | 18558490 | ||
| K562 ATCC CCL 243 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 ATCC CCL 243 cells after 72 hrs by MTT assay, IC50 = 4.9 μM. | 18558490 | ||
| MCF7 ATCC HTB 22 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 ATCC HTB 22 cells after 72 hrs by MTT assay, IC50 = 12.2 μM. | 18558490 | ||
| U251 RCB 0641 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human U251 RCB 0641 cells after 72 hrs by MTT assay, IC50 = 0.5 μM. | 18558490 | ||
| 3LL CRL 1642 | Cytotoxicity assay | 48 hrs | Cytotoxicity against mouse 3LL CRL 1642 cells after 48 hrs by MTT assay, IC50 = 4 μM. | 18558490 | ||
| L1210 ATCC CCL 219 | Cytotoxicity assay | 48 hrs | Cytotoxicity against mouse L1210 ATCC CCL 219 cells after 48 hrs by MTT assay, IC50 = 0.5 μM. | 18558490 | ||
| SK-Hep1 | Cytotoxicity assay | Cytotoxicity against human SK-Hep1 cells by MTT assay, IC50 = 49.6 μM. | 18637688 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by SRB assay, IC50 = 0.2 μM. | 18651771 | |||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells assessed as reduction of cell growth by SRB method, IC50 = 9.98 μM. | 18782668 | |||
| KB | Cytotoxicity assay | Cytotoxicity against human KB cells assessed as reduction of cell growth by SRB method, IC50 = 14.2 μM. | 18782668 | |||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 8.37 μM. | 18844422 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 1.25 μM. | 18844422 | ||
| AGS | Cytotoxicity assay | 3 days | Cytotoxicity against human AGS cells after 3 days by MTT assay, IC50 = 0.36 μM. | 19013074 | ||
| HL-60 | Cytotoxicity assay | 3 days | Cytotoxicity against human HL-60 cells after 3 days by MTT assay, IC50 = 0.8 μM. | 19013074 | ||
| J82 | Cytotoxicity assay | 3 days | Cytotoxicity against human J82 cells after 3 days by MTT assay, IC50 = 2.8 μM. | 19013074 | ||
| MRC5 | Cytotoxicity assay | 3 days | Cytotoxicity against human MRC5 cells after 3 days by MTT assay, IC50 = 3.9 μM. | 19013074 | ||
| SK-MES-1 | Cytotoxicity assay | 3 days | Cytotoxicity against human SK-MES-1 cells after 3 days by MTT assay, IC50 = 2.5 μM. | 19013074 | ||
| A375 | Cytotoxicity assay | Cytotoxicity against human A375 cells by MTT assay, IC50 = 3.92 μM. | 19036584 | |||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by MTT assay, IC50 = 9.51 μM. | 19036584 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by MTT assay, IC50 = 1.83 μM. | 19036584 | |||
| THP1 | Cytotoxicity assay | Cytotoxicity against human THP1 cells by MTT assay, IC50 = 2.16 μM. | 19036584 | |||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 5.9 μM. | 19053514 | ||
| HL-60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay, IC50 = 0.25 μM. | 19053514 | ||
| U937 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human U937 cells after 72 hrs by MTT assay, IC50 = 0.92 μM. | 19053514 | ||
| ACHN | Antiproliferative assay | 96 hrs | Antiproliferative activity against human ACHN cells after 96 hrs by MTT assay, IC50 = 2.15 μM. | 19053767 | ||
| CCRF-CEM | Antiproliferative assay | 96 hrs | Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay, IC50 = 1.2 μM. | 19053767 | ||
| CCRF-SB | Antiproliferative assay | 96 hrs | Antiproliferative activity against human CCRF-SB cells after 96 hrs by MTT assay, IC50 = 0.1 μM. | 19053767 | ||
| HeLa | Antiproliferative assay | 96 hrs | Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay, IC50 = 3 μM. | 19053767 | ||
| HT-29 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay, IC50 = 2.5 μM. | 19053767 | ||
| MCF7 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay, IC50 = 1 μM. | 19053767 | ||
| MRC5 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human MRC5 cells after 96 hrs by MTT assay, IC50 = 3.9 μM. | 19053767 | ||
| MT4 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human MT4 cells after 96 hrs by MTT assay, IC50 = 1.25 μM. | 19053767 | ||
| SF-268 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human SF-268 cells after 96 hrs by MTT assay, IC50 = 3.25 μM. | 19053767 | ||
| XF498 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human XF498 cells after 96 hrs by MTT assay, IC50 = 3.45 μM. | 19053767 | ||
| KB | Growth inhibition assay | 72 hrs | Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay, IC50 = 1.1 μM. | 19053773 | ||
| KB-TAX50 | Growth inhibition assay | 72 hrs | Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-TAX50 cells after 72 hrs by methylene blue dye assay, IC50 = 3.5 μM. | 19053773 | ||
| KB-VIN10 | Growth inhibition assay | 72 hrs | Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay, IC50 = 23 μM. | 19053773 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay, IC50 = 1.7 μM. | 19072209 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by WST-8 assay, IC50 = 7.6 μM. | 19072209 | ||
| NB4 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human NB4 cells after 48 hrs by WST-8 assay, IC50 = 1.3 μM. | 19072209 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells after 48 hrs by WST-8 assay, IC50 = 13.6 μM. | 19072209 | ||
| SH-SY5Y | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SH-SY5Y cells after 48 hrs by WST-8 assay, IC50 = 1.7 μM. | 19072209 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs, IC50 = 1.2 μM. | 19115839 | ||
| DLD1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DLD1 cells after 48 hrs, IC50 = 27 μM. | 19115839 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs, IC50 = 0.7 μM. | 19115839 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells after 48 hrs, IC50 = 1.7 μM. | 19115839 | ||
| WS1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human WS1 cells after 48 hrs, IC50 = 34 μM. | 19115839 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 3.3 μM. | 19251420 | ||
| AGS | Cytotoxicity assay | 72 hrs | Cytotoxicity against human AGS cells after 72 hrs by MTT assay, IC50 = 0.36 μM. | 19269832 | ||
| J82 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human J82 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. | 19269832 | ||
| MRC5 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50 = 3.9 μM. | 19269832 | ||
| SKMES1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKMES1 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. | 19269832 | ||
| HCT15 | Antiproliferative assay | Antiproliferative activity against human HCT15 cells by SRB assay, GI50 = 1.25 μM. | 19394218 | |||
| MESSA | Antiproliferative assay | Antiproliferative activity against human MESSA cells by SRB assay, GI50 = 0.21 μM. | 19394218 | |||
| HCT15/CLO2 | Antiproliferative assay | Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay, GI50 = 10.02 μM. | 19394218 | |||
| MES-SA/Dx5 | Antiproliferative assay | Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay, GI50 = 9.72 μM. | 19394218 | |||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 14.3 μM. | 19394829 | ||
| CCRF-CEM | Cytotoxicity assay | 72 hrs | Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay, IC50 = 1.1 μM. | 19394829 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 3.9 μM. | 19394829 | ||
| Jurkat | Cytotoxicity assay | 72 hrs | Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay, IC50 = 1.2 μM. | 19394829 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 10.9 μM. | 19394829 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 21.2 μM. | 19394829 | ||
| AGS | Cytotoxicity assay | 3 days | Cytotoxicity against human AGS cells after 3 days by MTT assay, IC50 = 0.36 μM. | 19419803 | ||
| HL60 | Cytotoxicity assay | 3 days | Cytotoxicity against human HL60 cells after 3 days by MTT assay, IC50 = 0.8 μM. | 19419803 | ||
| J82 | Cytotoxicity assay | 3 days | Cytotoxicity against human J82 cells after 3 days by MTT assay, IC50 = 2.5 μM. | 19419803 | ||
| MRC5 | Cytotoxicity assay | 3 days | Cytotoxicity against human MRC5 cells after 3 days by MTT assay, IC50 = 3.93 μM. | 19419803 | ||
| SKMES1 | Cytotoxicity assay | 3 days | Cytotoxicity against human SKMES1 cells after 3 days by MTT assay, IC50 = 2.8 μM. | 19419803 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by SRB method, IC50 = 1.7 μM. | 19425589 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by SRB method, IC50 = 7.6 μM. | 19425589 | ||
| NB4 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human NB4 cells after 48 hrs by SRB method, IC50 = 1.3 μM. | 19425589 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells after 48 hrs by SRB method, IC50 = 13.6 μM. | 19425589 | ||
| SH-SY5Y | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SH-SY5Y cells after 48 hrs by SRB method, IC50 = 1.7 μM. | 19425589 | ||
| HT-29 | Cytotoxicity assay | 96 hrs | Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay, GI50 = 0.73 μM. | 19572549 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 0.63 μM. | 19685913 | ||
| Bel7402 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay, IC50 = 1.03 μM. | 19685913 | ||
| HL60 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HL60 cells after 24 hrs by SRB assay, IC50 = 0.042 μM. | 19685913 | ||
| P388 | Cytotoxicity assay | 24 hrs | Cytotoxicity against mouse P388 cells after 24 hrs by SRB assay, IC50 = 0.05 μM. | 19685913 | ||
| HCT116 | Antiproliferative assay | 3 days | Antiproliferative activity against human HCT116 cells after 3 days by XTT assay, IC50 = 1.7 μM. | 19691293 | ||
| SW948 | Antiproliferative assay | 3 days | Antiproliferative activity against human SW948 cells after 3 days by XTT assay, IC50 = 1.3 μM. | 19691293 | ||
| A549 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human A549 cells after 24 hrs by SRB assay, IC50 = 0.63 μM. | 19769341 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.042 μM. | 19769341 | ||
| A375 | Cytotoxicity assay | Cytotoxicity against human A375 cells by MTT assay, IC50 = 3.92 μM. | 19782567 | |||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by MTT assay, IC50 = 9.51 μM. | 19782567 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by MTT assay, IC50 = 2.16 μM. | 19782567 | |||
| THP1 | Cytotoxicity assay | Cytotoxicity against human THP1 cells by MTT assay, IC50 = 1.83 μM. | 19782567 | |||
| HONE1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HONE1 cells after 72 hrs by methylene blue dye assay, IC50 = 1.2 μM. | 19785430 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue dye assay, IC50 = 2.3 μM. | 19785430 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by methylene blue dye assay, IC50 = 1.3 μM. | 19785430 | ||
| H69 | Cytotoxicity assay | Cytotoxicity against human adriamycin resistant H69 cells, IC50 = 46 μM. | 19788270 | |||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells, IC50 = 0.4 μM. | 19788270 | |||
| HuCCa1 | Cytotoxicity assay | Cytotoxicity against human HuCCa1 cells, IC50 = 5.1 μM. | 19788270 | |||
| KB | Cytotoxicity assay | Cytotoxicity against human KB cells, IC50 = 0.5 μM. | 19788270 | |||
| MDA-MB-231 | Cytotoxicity assay | Cytotoxicity against human MDA-MB-231 cells, IC50 = 0.3 μM. | 19788270 | |||
| T47D | Cytotoxicity assay | Cytotoxicity against human T47D cells, IC50 = 0.1 μM. | 19788270 | |||
| HCT116 | Cytotoxicity assay | 4 days | Cytotoxicity against human HCT116 cells after 4 days, IC50 = 14.39 μM. | 19800803 | ||
| DU145 | Cytotoxicity assay | Cytotoxicity against human DU145 cells by MTT assay, IC50 = 5.16 μM. | 19836231 | |||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells by MTT assay, IC50 = 2.15 μM. | 19836231 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by MTT assay, IC50 = 0.93 μM. | 19836231 | |||
| HT-29 | Cytotoxicity assay | Cytotoxicity against human HT-29 cells by MTT assay, IC50 = 6.32 μM. | 19836231 | |||
| MDA-MB-231 | Cytotoxicity assay | Cytotoxicity against human MDA-MB-231 cells by MTT assay, IC50 = 3.5 μM. | 19836231 | |||
| HaCaT | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HaCaT cells after 72 hrs by MTT assay, IC50 = 0.55 μM. | 19919064 | ||
| B16 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay, IC50 = 0.28 μM. | 19919064 | ||
| DU145 | Cytotoxicity assay | 4 days | Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay, IC50 = 1.3 μM. | 19939682 | ||
| HCT15 | Cytotoxicity assay | 4 days | Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay, IC50 = 1.09 μM. | 19939682 | ||
| HeLa | Cytotoxicity assay | 4 days | Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay, IC50 = 1.29 μM. | 19939682 | ||
| K562 | Cytotoxicity assay | 4 days | Cytotoxicity against human K562 cells after 4 days by ELISA reader assay, IC50 = 2.41 μM. | 19939682 | ||
| MCF7 | Cytotoxicity assay | 4 days | Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay, IC50 = 1.89 μM. | 19939682 | ||
| DU145 | Cytotoxicity assay | 3 days | Cytotoxicity against human DU145 cells after 3 days, IC50 = 21.07 μM. | 19954977 | ||
| HCT116 | Cytotoxicity assay | 3 days | Cytotoxicity against human HCT116 cells after 3 days, IC50 = 17.92 μM. | 19954977 | ||
| HeLa | Cytotoxicity assay | 3 days | Cytotoxicity against human HeLa cells after 3 days, IC50 = 8.43 μM. | 19954977 | ||
| MCF7 | Cytotoxicity assay | 3 days | Cytotoxicity against human MCF7 cells after 3 days, IC50 = 18.01 μM. | 19954977 | ||
| MDA-MB-231 | Cytotoxicity assay | 3 days | Cytotoxicity against human MDA-MB-231 cells after 3 days, IC50 = 16.85 μM. | 19954977 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells after 72 hrs by MTS assay, IC50 = 0.42 μM. | 20006518 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs, IC50 = 0.29 μM. | 20053564 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs, IC50 = 0.42 μM. | 20053564 | ||
| RPMI8226 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human RPMI8226 cells after 48 hrs, IC50 = 0.14 μM. | 20053564 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 0.83 μM. | 20071056 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method, IC50 = 0.18 μM. | 20071056 | ||
| RPMI8226 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method, IC50 = 0.7 μM. | 20071056 | ||
| DU145 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 1.63 μM. | 20093033 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 0.47 μM. | 20093033 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.97 μM. | 20093033 | ||
| HT-29 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.42 μM. | 20093033 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 2.87 μM. | 20093033 | ||
| KB | Cytotoxicity assay | Cytotoxicity against human KB cells, EC50 = 1.1 μM. | 20102168 | |||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by MTT assay, ED50 = 0.2 μM. | 20187635 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 0.6 μM. | 20187635 | ||
| KB1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB1 cells after 72 hrs by MTT assay, IC50 = 34.8 μM. | 20187635 | ||
| KB-7d | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB-7d cells after 72 hrs by MTT assay, ED50 = 25 μM. | 20187635 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay, IC50 = 28.7 μM. | 20187635 | ||
| DU145 | Cytotoxicity assay | Cytotoxicity against human DU145 cells in presence of 10% fetal bovine serum, IC50 = 2.45 μM. | 20188578 | |||
| HCT15 | Cytotoxicity assay | Cytotoxicity against human HCT15 cells in presence of 10% fetal bovine serum, IC50 = 1.29 μM. | 20188578 | |||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells in presence of 10% fetal bovine serum, IC50 = 1.57 μM. | 20188578 | |||
| K562 | Cytotoxicity assay | Cytotoxicity against human K562 cells in presence of 10% fetal bovine serum, IC50 = 2.84 μM. | 20188578 | |||
| NCI-H460 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human NCI-H460 cells after 48 hrs by [3H]thymidine incorporation assay, IC50 = 0.09 μM. | 20210346 | ||
| SKHEP1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SKHEP1 cells after 48 hrs by [3H]thymidine incorporation assay, IC50 = 0.062 μM. | 20210346 | ||
| U87MG | Cytotoxicity assay | 48 hrs | Cytotoxicity against human U87MG cells after 48 hrs by [3H]thymidine incorporation assay, IC50 = 0.145 μM. | 20210346 | ||
| HepG2 | Growth inhibition assay | 72 hrs | Growth inhibition of human HepG2 cells after 72 hrs by sulforhodamine B assay, IC50 = 4.1 μM. | 20346660 | ||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells by MTT assay, IC50 = 8.93 μM. | 20356735 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells by MTT assay, IC50 = 1.81 μM. | 20356735 | |||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system, IC50 = 0.5 μM. | 20392646 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system, IC50 = 1.1 μM. | 20392646 | ||
| HeLa | Cytotoxicity assay | 2 days | Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system, IC50 = 1.4 μM. | 20392646 | ||
| HL60 | Cytotoxicity assay | 2 days | Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system, IC50 = 1 μM. | 20392646 | ||
| MDA-MB-231 | Cytotoxicity assay | 2 days | Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system, IC50 = 0.7 μM. | 20392646 | ||
| HM-SFME-1 | Antiproliferative assay | 24 hrs | Antiproliferative activity against mouse r/m HM-SFME-1 cells after 24 hrs by MTT assay, IC50 = 9 μM. | 20398972 | ||
| SFME | Antiproliferative assay | 24 hrs | Antiproliferative activity against mouse SFME cells after 24 hrs by MTT assay, IC50 = 0.5 μM. | 20398972 | ||
| HT-29 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 30.38 μM. | 20405844 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 23.22 μM. | 20405844 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction assay, IC50 = 16 μM. | 20413315 | ||
| DLD1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction assay, IC50 = 10 μM. | 20413315 | ||
| WS1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction assay, IC50 = 4.3 μM. | 20413315 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50 = 0.63 μM. | 20415462 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.042 μM. | 20415462 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.39 μM. | 20524638 | ||
| HL60/MX2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60/MX2 cells after 72 hrs by MTT assay, IC50 = 11.9 μM. | 20570510 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human topoisomerase 2-sensitive HL60 cells after 72 hrs by MTT assay, IC50 = 1.3 μM. | 20570510 | ||
| A375 | Cytotoxicity assay | 24 hrs | Cytotoxicity activity against human A375 cells after 24 hrs by NRU assay, IC50 = 19 μM. | 20570625 | ||
| A375 | Cytotoxicity assay | 48 hrs | Cytotoxicity activity against human A375 cells after 48 hrs by NRU assay, IC50 = 12 μM. | 20570625 | ||
| B16 | Cytotoxicity assay | 24 hrs | Cytotoxicity activity against mouse B16 cells after 24 hrs by NRU assay, IC50 = 9 μM. | 20570625 | ||
| B16 | Cytotoxicity assay | 48 hrs | Cytotoxicity activity against mouse B16 cells after 48 hrs by NRU assay, IC50 = 0.13 μM. | 20570625 | ||
| DU145 | Cytotoxicity assay | 4 days | Cytotoxicity against human DU145 cells after 4 days by MTT assay, IC50 = 13.8 μM. | 20619511 | ||
| HCT116 | Cytotoxicity assay | 4 days | Cytotoxicity against human HCT116 cells after 4 days by MTT assay, IC50 = 11.9 μM. | 20619511 | ||
| HeLa | Cytotoxicity assay | 4 days | Cytotoxicity against human HeLa cells after 4 days by MTT assay, IC50 = 18.2 μM. | 20619511 | ||
| MCF7 | Cytotoxicity assay | 4 days | Cytotoxicity against human MCF7 cells after 4 days by MTT assay, IC50 = 17.5 μM. | 20619511 | ||
| MDA-MB-231 | Cytotoxicity assay | 4 days | Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay, IC50 = 16.3 μM. | 20619511 | ||
| AGS | Cytotoxicity assay | 72 hrs | Cytotoxicity against human AGS cells after 72 hrs by MTT assay, IC50 = 0.36 μM. | 20828890 | ||
| HL-60(TB) | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL-60(TB) cells after 72 hrs by MTT assay, IC50 = 0.8 μM. | 20828890 | ||
| J82 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human J82 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. | 20828890 | ||
| MRC5 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay, IC50 = 3.9 μM. | 20828890 | ||
| SKMES1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKMES1 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. | 20828890 | ||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells, IC50 = 0.49 μM. | 20863598 | |||
| colon cancer cells | Growth inhibition assay | 72 hrs | Growth inhibition of human colon cancer cells after 72 hrs by sulforhodamine B assay, GI50 = 1.3 μM. | 20884089 | ||
| gastric cancer cells | Growth inhibition assay | 72 hrs | Growth inhibition of human gastric cancer cells after 72 hrs by sulforhodamine B assay, GI50 = 1.3 μM. | 20884089 | ||
| lung cancer cells | Growth inhibition assay | 72 hrs | Growth inhibition of human lung cancer cells after 72 hrs by sulforhodamine B assay, GI50 = 1.3 μM. | 20884089 | ||
| HCT15 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 1.6 μM. | 20939516 | ||
| MESSA | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MESSA cells after 48 hrs by sulforhodamine B assay, IC50 = 0.3 μM. | 20939516 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs, IC50 = 0.486 μM. | 20961767 | ||
| HL60/MX2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60/MX2 cells after 72 hrs, IC50 = 48.5 μM. | 20961767 | ||
| KB | Cytotoxicity assay | 3 days | Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay, EC50 = 4.5 μM. | 21028898 | ||
| NCI60 | Growth inhibition assay | Growth inhibition of human NCI60 cells by SBR assay, GI50 = 38.9045 μM. | 21035334 | |||
| 502713 | Anticancer assay | 48 hrs | Anticancer activity against human 502713 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 0.1 μM. | 21074444 | ||
| A549 | Anticancer assay | 48 hrs | Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 3.08 μM. | 21074444 | ||
| DU145 | Anticancer assay | 48 hrs | Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 3.7 μM. | 21074444 | ||
| HCT15 | Anticancer assay | 48 hrs | Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 0.9 μM. | 21074444 | ||
| Hep2 | Anticancer assay | 48 hrs | Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 0.9 μM. | 21074444 | ||
| IMR32 | Anticancer assay | 48 hrs | Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 6.3 μM. | 21074444 | ||
| PC3 | Anticancer assay | 48 hrs | Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 2.6 μM. | 21074444 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.62 μM. | 21115210 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells after 72 hrs by MTT assay, GI50 = 12.59 μM. | 21115210 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.95 μM. | 21115210 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50 = 0.63 μM. | 21115210 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, TGI = 3.98 μM. | 21115210 | ||
| DU145 | Cytotoxicity assay | Cytotoxicity against human DU145 cells by MTT assay, IC50 = 1.44 μM. | 21115246 | |||
| HCT15 | Cytotoxicity assay | Cytotoxicity against human HCT15 cells by MTT assay, IC50 = 2.03 μM. | 21115246 | |||
| K562 | Cytotoxicity assay | Cytotoxicity against human K562 cells by MTT assay, IC50 = 1.21 μM. | 21115246 | |||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 1.98 μM. | 21115246 | |||
| 95-D | Cytotoxicity assay | 72 hrs | Cytotoxicity against human 95-D cells after 72 hrs by MTT assay, IC50 = 0.0202 μM. | 21145139 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 0.00256 μM. | 21145139 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 0.00461 μM. | 21145139 | ||
| KB/VCR | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB/VCR cells after 72 hrs by MTT assay, IC50 = 0.0834 μM. | 21145139 | ||
| HepG2 | Cytotoxicity assay | Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 15.8 μM. | 21174408 | |||
| MOLT3 | Cytotoxicity assay | Cytotoxicity against human MOLT3 cells by XTT assay, IC50 = 0.03 μM. | 21174408 | |||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by SRB assay, IC50 = 1.85 μM. | 21182258 | |||
| SK-MEL-2 | Cytotoxicity assay | Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50 = 1.17 μM. | 21182258 | |||
| SKOV3 | Cytotoxicity assay | Cytotoxicity against human SKOV3 cells by SRB assay, IC50 = 1.81 μM. | 21182258 | |||
| XF498 | Cytotoxicity assay | Cytotoxicity against human XF498 cells by SRB assay, IC50 = 1.72 μM. | 21182258 | |||
| A549 | Cytotoxicity assay | 3 days | Cytotoxicity against human A549 cells assessed as cell growth inhibition after 3 days by MTT assay, IC50 = 21.4 μM. | 21277655 | ||
| HCT116 | Cytotoxicity assay | 3 days | Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 3 days by MTT assay, IC50 = 13.5 μM. | 21277655 | ||
| HepG2 | Cytotoxicity assay | 3 days | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 3 days by MTT assay, IC50 = 4.9 μM. | 21277655 | ||
| HT1080 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human HT1080 cells after 96 hrs by MTT assay, IC50 = 0.75 μM. | 21296467 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 11 μM. | 21397370 | ||
| A2780 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A2780 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 1.3 μM. | 21402478 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 3.08 μM. | 21402478 | ||
| COLO205 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 0.13 μM. | 21402478 | ||
| KB | Cytotoxicity assay | 48 hrs | Cytotoxicity against human KB cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 0.3 μM. | 21402478 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B based ELISA, GI50 = 2.1 μM. | 21402478 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days, IC50 = 2.19 μM. | 21419530 | ||
| HCT116 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT116 cells after 2 days, IC50 = 9.5 μM. | 21419530 | ||
| HeLa | Cytotoxicity assay | 2 days | Cytotoxicity against human HeLa cells after 2 days, IC50 = 2.36 μM. | 21419530 | ||
| HL60 | Cytotoxicity assay | 2 days | Cytotoxicity against human HL60 cells after 2 days, IC50 = 1.28 μM. | 21419530 | ||
| MDA-MB-231 | Cytotoxicity assay | 2 days | Cytotoxicity against human MDA-MB-231 cells after 2 days, IC50 = 1.23 μM. | 21419530 | ||
| A549 | Anticancer assay | Anticancer activity against human A549 cells by SRB assay, IC50 = 1.85 μM. | 21420296 | |||
| SK-MEL-2 | Anticancer assay | Anticancer activity against human SK-MEL-2 cells by SRB assay, IC50 = 1.17 μM. | 21420296 | |||
| SKOV3 | Anticancer assay | Anticancer activity against human SKOV3 cells by SRB assay, IC50 = 1.81 μM. | 21420296 | |||
| XF498 | Anticancer assay | Anticancer activity against human XF498 cells by SRB assay, IC50 = 1.72 μM. | 21420296 | |||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells, IC50 = 1.4 μM. | 21439821 | |||
| HL60/MX2 | Cytotoxicity assay | Cytotoxicity against human HL60/MX2 cells, IC50 = 15.75 μM. | 21439821 | |||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay, IC50 = 5.62 μM. | 21477899 | ||
| HCT15 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay, IC50 = 7.15 μM. | 21477899 | ||
| Hep2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human Hep2 cells after 48 hrs by sulforhodamine B assay, IC50 = 2.15 μM. | 21477899 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay, IC50 = 19 μM. | 21477899 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay, IC50 = 17.5 μM. | 21477899 | ||
| SF295 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay, IC50 = 13.5 μM. | 21477899 | ||
| A2780 | Growth inhibition assay | 48 hrs | Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.3 μM. | 21489802 | ||
| A549 | Growth inhibition assay | 48 hrs | Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. | 21489802 | ||
| COLO205 | Growth inhibition assay | 48 hrs | Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. | 21489802 | ||
| DWD | Growth inhibition assay | 48 hrs | Growth inhibition of human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.6 μM. | 21489802 | ||
| Gurav | Growth inhibition assay | 48 hrs | Growth inhibition of human Gurav cells after 48 hrs by sulforhodamine B assay, GI50 = 0.5 μM. | 21489802 | ||
| HOP62 | Growth inhibition assay | 48 hrs | Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. | 21489802 | ||
| KB | Growth inhibition assay | 48 hrs | Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay, GI50 = 0.3 μM. | 21489802 | ||
| MCF7 | Growth inhibition assay | 48 hrs | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.1 μM. | 21489802 | ||
| PC3 | Growth inhibition assay | 48 hrs | Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.6 μM. | 21489802 | ||
| SiHa | Growth inhibition assay | 48 hrs | Growth inhibition of human SiHa cells after 48 hrs by sulforhodamine B assay, GI50 = 3.1 μM. | 21489802 | ||
| ZR-75-1 | Growth inhibition assay | 48 hrs | Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. | 21489802 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 4 μM. | 21570846 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50 = 10 μM. | 21570846 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days, IC50 = 0.5 μM. | 21601964 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days, IC50 = 1.1 μM. | 21601964 | ||
| HeLa | Cytotoxicity assay | 2 days | Cytotoxicity against human HeLa cells after 2 days, IC50 = 1.4 μM. | 21601964 | ||
| HL60 | Cytotoxicity assay | 2 days | Cytotoxicity against human HL60 cells after 2 days, IC50 = 1 μM. | 21601964 | ||
| MDA-MB-231 | Cytotoxicity assay | 2 days | Cytotoxicity against human MDA-MB-231 cells after 2 days, INH = 0.7 μM. | 21601964 | ||
| AGS | Anticancer assay | 3 days | Anticancer activity against human AGS cells after 3 days by MTT assay, IC50 = 0.36 μM. | 21621882 | ||
| J82 | Anticancer assay | 3 days | Anticancer activity against human J82 cells after 3 days by MTT assay, IC50 = 0.8 μM. | 21621882 | ||
| MRC5 | Anticancer assay | 3 days | Anticancer activity against human MRC5 cells after 3 days by MTT assay, IC50 = 3.9 μM. | 21621882 | ||
| SKMES1 | Anticancer assay | 3 days | Anticancer activity against human SKMES1 cells after 3 days by MTT assay, IC50 = 2.8 μM. | 21621882 | ||
| Caco2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human Caco2 cells after 72 hrs by MTS assay, IC50 = 18.6 μM. | 21724394 | ||
| CCD-18Co | Cytotoxicity assay | 72 hrs | Cytotoxicity against human CCD-18Co cells after 72 hrs by MTS assay, IC50 = 44.4 μM. | 21724394 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay, IC50 = 25.5 μM. | 21724394 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 14.8 μM. | 21733601 | ||
| SiHa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SiHa cells after 48 hrs by MTT assay, IC50 = 30.7 μM. | 21733601 | ||
| A2780 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.3 μM. | 21737288 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. | 21737288 | ||
| COLO205 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. | 21737288 | ||
| DWD | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.6 μM. | 21737288 | ||
| Gurav | Cytotoxicity assay | 48 hrs | Cytotoxicity against human Gurav cells after 48 hrs by sulforhodamine B assay, GI50 = 0.5 μM. | 21737288 | ||
| HOP62 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. | 21737288 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.1 μM. | 21737288 | ||
| ZR-75-1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. | 21737288 | ||
| CCRF-CEM | Antiproliferative assay | 96 hrs | Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay, CC50 = 0.09 μM. | 21741130 | ||
| CCRF-SB | Antiproliferative assay | 96 hrs | Antiproliferative activity against human CCRF-SB cells after 96 hrs by MTT assay, CC50 = 0.1 μM. | 21741130 | ||
| DU145 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay, CC50 = 0.4 μM. | 21741130 | ||
| HepG2 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human HepG2 cells after 96 hrs by MTT assay, CC50 = 0.7 μM. | 21741130 | ||
| MCF7 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay, CC50 = 1 μM. | 21741130 | ||
| SK-MEL-28 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human SK-MEL-28 cells after 96 hrs by MTT assay, CC50 = 1.2 μM. | 21741130 | ||
| SKMES1 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human SKMES1 cells after 96 hrs by MTT assay, CC50 = 0.3 μM. | 21741130 | ||
| WIL2-NS | Antiproliferative assay | 96 hrs | Antiproliferative activity against human WIL2-NS cells after 96 hrs by MTT assay, CC50 = 0.2 μM. | 21741130 | ||
| MT4 | Cytotoxicity assay | 96 hrs | Cytotoxicity against human MT4 cells infected with HTLV-1 after 96 hrs by MTT assay, CC50 = 0.09 μM. | 21741130 | ||
| HeLa | Cytotoxicity assay | 2 days | Cytotoxicity against human HeLa cells after 2 days by MTT assay, IC50 = 6.27 μM. | 21821321 | ||
| K562 | Cytotoxicity assay | 2 days | Cytotoxicity against human K562 cells after 2 days by MTT assay, IC50 = 2.11 μM. | 21821321 | ||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by sulforhodamine B assay, IC50 = 0.44 μM. | 21936523 | |||
| SK-MEL-2 | Cytotoxicity assay | Cytotoxicity against human SK-MEL-2 cells by sulforhodamine B assay, IC50 = 0.41 μM. | 21936523 | |||
| SKOV3 | Cytotoxicity assay | Cytotoxicity against human SKOV3 cells by sulforhodamine B assay, IC50 = 1.31 μM. | 21936523 | |||
| HeLa | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay, IC50 = 23.33 μM. | 21983445 | ||
| HBL100 | Growth inhibition assay | Growth inhibition of human HBL100 cells, GI50 = 2.3 μM. | 21986585 | |||
| HeLa | Growth inhibition assay | Growth inhibition of human HeLa cells, GI50 = 3 μM. | 21986585 | |||
| Ishikawa | Growth inhibition assay | Growth inhibition of human Ishikawa cells, GI50 = 11 μM. | 21986585 | |||
| SW1573 | Growth inhibition assay | Growth inhibition of human SW1573 cells, GI50 = 15 μM. | 21986585 | |||
| T47D | Growth inhibition assay | Growth inhibition of human T47D cells, GI50 = 22 μM. | 21986585 | |||
| WiDr | Growth inhibition assay | Growth inhibition of human WiDr cells, GI50 = 23 μM. | 21986585 | |||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 24.9 μM. | 22041063 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay, IC50 = 2.76 μM. | 22041063 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay, IC50 = 2.85 μM. | 22041063 | ||
| SiHa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 40.4 μM. | 22041063 | ||
| KB | Growth inhibition assay | 72 hrs | Growth inhibition of human KB cells after 72 hrs by methylene blue assay, IC50 = 1.1 μM. | 22060033 | ||
| KB-S15 | Growth inhibition assay | 72 hrs | Growth inhibition of human KB-S15 cells after 72 hrs by methylene blue assay, IC50 = 3.5 μM. | 22060033 | ||
| KB-VIN10 | Growth inhibition assay | 72 hrs | Growth inhibition of human KB-VIN10 cells after 72 hrs by methylene blue assay, IC50 = 23 μM. | 22060033 | ||
| CCRF-CEM | Cytotoxicity assay | 72 hrs | Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay, GI50 = 12.59 μM. | 22104973 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.62 μM. | 22104973 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.95 μM. | 22104973 | ||
| THP1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human THP1 cells after 48 hrs by MTT assay, IC50 = 2.16 μM. | 22115593 | ||
| U937 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human U937 cells after 48 hrs by MTT assay, IC50 = 17.94 μM. | 22115593 | ||
| B16F10 | Cytotoxicity assay | 48 hrs | Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay, IC50 = 18.69 μM. | 22115593 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 0.91 μM. | 22119124 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 5.16 μM. | 22119124 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 0.85 μM. | 22119124 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay, IC50 = 1.09 μM. | 22119124 | ||
| A375 | Anticancer assay | 48 hrs | Anticancer activity against human A375 cells after 48 hrs by MTT assay, IC50 = 1.39 μM. | 22136907 | ||
| A549 | Anticancer assay | 48 hrs | Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.34 μM. | 22136907 | ||
| ACHN | Anticancer assay | 48 hrs | Anticancer activity against human ACHN cells after 48 hrs by MTT assay, IC50 = 7.61 μM. | 22136907 | ||
| HT-29 | Anticancer assay | 48 hrs | Anticancer activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.81 μM. | 22136907 | ||
| MCF7 | Anticancer assay | 48 hrs | Anticancer activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 0.68 μM. | 22136907 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 24.9 μM. | 22244588 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay, IC50 = 40.4 μM. | 22244588 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay, IC50 = 2.85 μM. | 22244588 | ||
| SiHa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SiHa cells after 48 hrs by MTT assay, IC50 = 2.76 μM. | 22244588 | ||
| DU145 | Cytotoxicity assay | 96 hrs | Cytotoxicity against human DU145 cells after 96 hrs, IC50 = 3 μM. | 22276775 | ||
| HepG2 | Cytotoxicity assay | 96 hrs | Cytotoxicity against human HepG2 cells after 96 hrs, IC50 = 4 μM. | 22276775 | ||
| MT4 | Cytotoxicity assay | 96 hrs | Cytotoxicity against human MT4 cells after 96 hrs, IC50 = 0.09 μM. | 22276775 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days, IC50 = 2.94 μM. | 22318164 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days, IC50 = 1.33 μM. | 22318164 | ||
| HeLa | Cytotoxicity assay | 2 days | Cytotoxicity against human HeLa cells after 2 days, IC50 = 3.2 μM. | 22318164 | ||
| K562 | Cytotoxicity assay | 2 days | Cytotoxicity against human K562 cells after 2 days, IC50 = 2.09 μM. | 22318164 | ||
| MCF7 | Cytotoxicity assay | 2 days | Cytotoxicity against human MCF7 cells after 2 days, IC50 = 3.25 μM. | 22318164 | ||
| A549 | Cytotoxicity assay | 2 days | Cytotoxicity against human A549 cells after 2 days by MTT assay, IC50 = 9.51 μM. | 22325897 | ||
| HL60 | Cytotoxicity assay | 2 days | Cytotoxicity against human HL60 cells after 2 days by MTT assay, IC50 = 1.83 μM. | 22325897 | ||
| Jurkat | Cytotoxicity assay | 2 days | Cytotoxicity against human Jurkat cells after 2 days by MTT assay, IC50 = 5.35 μM. | 22325897 | ||
| THP1 | Cytotoxicity assay | 2 days | Cytotoxicity against human THP1 cells after 2 days by MTT assay, IC50 = 2.16 μM. | 22325897 | ||
| U937 | Cytotoxicity assay | 2 days | Cytotoxicity against human U937 cells after 2 days by MTT assay, IC50 = 17.94 μM. | 22325897 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 23.8 μM. | 22342101 | ||
| Hep3B | Cytotoxicity assay | 72 hrs | Cytotoxicity against human Hep3B cells after 72 hrs by MTT assay, IC50 = 6.7 μM. | 22342101 | ||
| U87 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human U87 cells after 72 hrs by MTT assay, IC50 = 12.4 μM. | 22342101 | ||
| A2780 | Growth inhibition assay | 48 hrs | Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.31 μM. | 22364746 | ||
| A549 | Growth inhibition assay | 48 hrs | Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. | 22364746 | ||
| COLO205 | Growth inhibition assay | 48 hrs | Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. | 22364746 | ||
| DWD | Growth inhibition assay | 48 hrs | Growth inhibition of human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.62 μM. | 22364746 | ||
| HOP62 | Growth inhibition assay | 48 hrs | Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. | 22364746 | ||
| KB | Growth inhibition assay | 48 hrs | Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay, GI50 = 0.31 μM. | 22364746 | ||
| MCF7 | Growth inhibition assay | 48 hrs | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.11 μM. | 22364746 | ||
| ZR-75-1 | Growth inhibition assay | 48 hrs | Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. | 22364746 | ||
| Vero | Cytotoxicity assay | 48 hrs | Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay, LC50 = 18 μM. | 22381050 | ||
| HEK293 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HEK293 cells after 48 hrs by MTT assay, LC50 = 28 μM. | 22381050 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis, IC50 = 1.21 μM. | 22503656 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis, IC50 = 1.17 μM. | 22503656 | ||
| HEK293 | Cytotoxicity assay | 2 days | Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis, IC50 = 1.21 μM. | 22503656 | ||
| T47D | Cytotoxicity assay | 2 days | Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis, IC50 = 2.39 μM. | 22503656 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 0.48 μM. | 22564383 | ||
| T98G | Cytotoxicity assay | 48 hrs | Cytotoxicity against human T98G cells expressing mutant p53 after 48 hrs by MTT assay, IC50 = 0.46 μM. | 22564383 | ||
| U87 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human U87 cells expressing wild-type p53 after 48 hrs by MTT assay, IC50 = 0.62 μM. | 22564383 | ||
| COLO205 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human COLO205 cells after 48 hrs by MTT assay, IC50 = 0.43 μM. | 22578452 | ||
| HepG2 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 4.76 μM. | 22578452 | ||
| THP1 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay, IC50 = 2.16 μM. | 22578452 | ||
| U937 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human U937 cells after 48 hrs by MTT assay, IC50 = 17.96 μM. | 22578452 | ||
| B16F10 | Antiproliferative assay | 48 hrs | Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay, IC50 = 18.71 μM. | 22578452 | ||
| CCRF-CEM | Cytotoxicity assay | 48 hrs | Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay, IC50 = 0.24 μM. | 22582991 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay, IC50 = 0.11 μM. | 22582991 | ||
| K562 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by celltiter-blue assay, IC50 = 2.3 μM. | 22582991 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, GI50 = 3.56 μM. | 22682920 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, TGI = 40.18 μM. | 22682920 | ||
| MCF7 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay, GI50 = 0.56 μM. | 22682920 | ||
| TK10 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human TK10 cells after 48 hrs by SRB assay, GI50 = 7.19 μM. | 22682920 | ||
| TK10 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human TK10 cells after 48 hrs by SRB assay, TGI = 49.74 μM. | 22682920 | ||
| UACC62 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human UACC62 cells after 48 hrs by SRB assay, GI50 = 0.89 μM. | 22682920 | ||
| Vero | Cytotoxicity assay | 72 hrs | Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay, IC50 = 31.14 μM. | 22687745 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 10.12 μM. | 22687745 | ||
| HepG2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 5.48 μM. | 22687745 | ||
| SGC7901 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay, IC50 = 12.09 μM. | 22687745 | ||
| SH-SY5Y | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay, IC50 = 5.37 μM. | 22687745 | ||
| L929 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay, IC50 = 1 μM. | 22687745 | ||
| KBCPT100 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50 = 0.336 μM. | 22698783 | ||
| KB | Antiproliferative assay | 72 hrs | Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay, IC50 = 0.475 μM. | 22698783 | ||
| KBCPT100 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human partially revertant camptothecin-resistant KBCPT100 cells after 72 hrs by ethylene blue dye assay, IC50 = 0.374 μM. | 22698783 | ||
| DU145 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human DU145 cells after 72 hrs by MTT assay, IC50 = 1.42 μM. | 22819942 | ||
| HCT15 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50 = 0.28 μM. | 22819942 | ||
| HEK293 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay, IC50 = 0.41 μM. | 22819942 | ||
| T47D | Cytotoxicity assay | 72 hrs | Cytotoxicity against human T47D cells after 72 hrs by MTT assay, IC50 = 1.21 μM. | 22819942 | ||
| A549 | Antiproliferative assay | 72 hrs | Antiproliferative activity at human A549 cells after 72 hrs by MTT assay, IC50 = 0.8 μM. | 22861499 | ||
| DMS53 | Antiproliferative assay | 72 hrs | Antiproliferative activity at human DMS53 cells after 72 hrs by MTT assay, IC50 = 1.5 μM. | 22861499 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.83 μM. | 22889556 | ||
| TK10 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay, GI50 = 5.89 μM. | 22889556 | ||
| TK10 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay, TGI = 43.33 μM. | 22889556 | ||
| UACC62 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.41 μM. | 22889556 | ||
| UACC62 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay, TGI = 4 μM. | 22889556 | ||
| DOGUM | Cytotoxicity assay | 72 hrs | Cytotoxicity against human DOGUM cells after 72 hrs by MTT assay, IC50 = 0.075 μM. | 23031590 | ||
| DOGUM | Cytotoxicity assay | 72 hrs | Cytotoxicity against human etoposide-resistant DOGUM cells after 72 hrs by MTT assay, IC50 = 0.28 μM. | 23031590 | ||
| GUMBUS | Cytotoxicity assay | 72 hrs | Cytotoxicity against human etoposide-resistant GUMBUS cells after 72 hrs by MTT assay, IC50 = 0.57 μM. | 23031590 | ||
| GUMBUS | Cytotoxicity assay | 72 hrs | Cytotoxicity against human GUMBUS cells after 72 hrs by MTT assay, IC50 = 0.042 μM. | 23031590 | ||
| Bel7402 | Cytotoxicity assay | Cytotoxicity against human Bel7402 cells, IC50 = 0.08 μM. | 23092389 | |||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells, IC50 = 0.08 μM. | 23092389 | |||
| SGC7901 | Cytotoxicity assay | Cytotoxicity against human SGC7901 cells, IC50 = 0.08 μM. | 23092389 | |||
| P388 | Cytotoxicity assay | Cytotoxicity against mouse P388 cells, IC50 = 0.08 μM. | 23092389 | |||
| A549 | Growth inhibition assay | 72 hrs | Growth inhibition of human A549 cells after 72 hrs by SRB assay, GI50 = 2.2 μM. | 23153810 | ||
| HT-29 | Growth inhibition assay | 72 hrs | Growth inhibition of human HT-29 cells after 72 hrs by SRB assay, GI50 = 9.4 μM. | 23153810 | ||
| MDA-MB-231 | Growth inhibition assay | 72 hrs | Growth inhibition of human MDA-MB-231 cells after 72 hrs by SRB assay, GI50 = 7.2 μM. | 23153810 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 2.8 μM. | 23182091 | ||
| ACHN | Cytotoxicity assay | 72 hrs | Cytotoxicity against human ACHN cells after 72 hrs by MTT assay, IC50 = 7.61 μM. | 23182091 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 1.52 μM. | 23182091 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, IC50 = 1.81 μM. | 23182091 | ||
| B16 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay, IC50 = 1.39 μM. | 23182091 | ||
| HeLa | Antitumor assay | 48 hrs | Antitumor activity against human HeLa cells assessed as growth inhibition measured after 48 hrs by MTT assay, IC50 = 8.32 μM. | 23313635 | ||
| HepG2 | Antitumor assay | 48 hrs | Antitumor activity against human HepG2 cells assessed as growth inhibition measured after 48 hrs by MTT assay, IC50 = 9.14 μM. | 23313635 | ||
| Vero | Cytotoxicity assay | 48 hrs | Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay, LC50 = 29 μM. | 23321564 | ||
| HEK293 | Cytotoxicity assay | 48 hrs | Cytotoxicity against HEK293 cells after 48 hrs by MTT assay, LC50 = 17 μM. | 23321564 | ||
| BGC832 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human BGC832 cells after 24 hrs by MTT assay, IC50 = 26.85 μM. | 23369687 | ||
| HeLa | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 17.68 μM. | 23369687 | ||
| K562 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human K562 cells after 24 hrs by MTT assay, IC50 = 2.85 μM. | 23369687 | ||
| AGS | Cytotoxicity assay | 72 hrs | Cytotoxicity against human AGS cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 0.36 μM. | 23454511 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.8 μM. | 23454511 | ||
| J82 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human J82 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 2.8 μM. | 23454511 | ||
| MRC5 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MRC5 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 3.9 μM. | 23454511 | ||
| SKMES1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKMES1 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 2.5 μM. | 23454511 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50 = 2.58 μM. | 23490151 | ||
| DU145 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human DU145 cells after 72 hrs by SRB assay, IC50 = 2.03 μM. | 23490151 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50 = 3.88 μM. | 23490151 | ||
| SNU638 | Cytotoxicity assay | Cytotoxicity against human SNU638 cells by MTT assay, IC50 = 2.57 μM. | 23608763 | |||
| T47D | Cytotoxicity assay | Cytotoxicity against human T47D cells by MTT assay, IC50 = 4.98 μM. | 23608763 | |||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 6.41 μM. | 23668986 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 3.2 μM. | 23711769 | ||
| HCT8 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 7.06 μM. | 23711769 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 2.91 μM. | 23711769 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay, IC50 = 1.15 μM. | 23711769 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.62 μM. | 23831811 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.95 μM. | 23831811 | ||
| A2780 | Growth inhibition assay | 48 hrs | Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay, GI50 = 1.31 μM. | 23849207 | ||
| A549 | Growth inhibition assay | 48 hrs | Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay, GI50 = 3.08 μM. | 23849207 | ||
| COLO205 | Growth inhibition assay | 48 hrs | Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.13 μM. | 23849207 | ||
| DWD | Growth inhibition assay | 48 hrs | Growth inhibition of human DWD cells after 48 hrs by sulforhodamine B assay, GI50 = 0.62 μM. | 23849207 | ||
| Gurav | Growth inhibition assay | 48 hrs | Growth inhibition of human Gurav cells after 48 hrs by sulforhodamine B assay, GI50 = 0.51 μM. | 23849207 | ||
| HOP62 | Growth inhibition assay | 48 hrs | Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.8 μM. | 23849207 | ||
| KB | Growth inhibition assay | 48 hrs | Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay, GI50 = 0.31 μM. | 23849207 | ||
| MCF7 | Growth inhibition assay | 48 hrs | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay, GI50 = 2.11 μM. | 23849207 | ||
| SiHa | Growth inhibition assay | 48 hrs | Growth inhibition of human SiHa cells after 48 hrs by sulforhodamine B assay, GI50 = 3.11 μM. | 23849207 | ||
| ZR-75-1 | Growth inhibition assay | 48 hrs | Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay, GI50 = 0.2 μM. | 23849207 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.5 μM. | 23865778 | ||
| U937 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human U937 cells after 72 hrs by MTT assay, IC50 = 1.4 μM. | 23865778 | ||
| H460 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human H460 cells after 48 hrs by MTT assay, IC50 = 1 μM. | 23867385 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 5.48 μM. | 23867385 | ||
| H460 | Cytotoxicity assay | Cytotoxicity against human H460 cells assessed as growth inhibition by MTT assay, IC50 = 30 μM. | 23920485 | |||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells assessed as growth inhibition by MTT assay, IC50 = 20.9 μM. | 23920485 | |||
| PC3 | Cytotoxicity assay | Cytotoxicity against human PC3 cells assessed as growth inhibition by MTT assay, IC50 = 18.2 μM. | 23920485 | |||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 32.05 μM. | 23968711 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.33 μM. | 23968711 | ||
| K562 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 8.45 μM. | 23968711 | ||
| MCF10A | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF10A cells after 72 hrs by MTT assay, IC50 = 36.26 μM. | 23999041 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay, GI50 = 0.87 μM. | 23999041 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 1.2 μM. | 23999041 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay, GI50 = 1.67 μM. | 23999041 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 1.5 μM. | 23999041 | ||
| A549 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 14.3 μM. | 24012378 | ||
| CCRF-CEM | Antiproliferative assay | 72 hrs | Antiproliferative activity against human CCRF-CEM cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.1 μM. | 24012378 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 3.9 μM. | 24012378 | ||
| Jurkat | Antiproliferative assay | 72 hrs | Antiproliferative activity against human Jurkat cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.2 μM. | 24012378 | ||
| MCF7 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 10.9 μM. | 24012378 | ||
| MDA-MB-231 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 21.2 μM. | 24012378 | ||
| HEK293 | Cytotoxicity assay | 2 days | Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay, IC50 = 0.72 μM. | 24013413 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50 = 9.29 μM. | 24013413 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50 = 5.12 μM. | 24013413 | ||
| T47D | Cytotoxicity assay | 2 days | Cytotoxicity against human T47D cells after 2 days by CCK-8 assay, IC50 = 3.42 μM. | 24013413 | ||
| A549 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 1.71 μM. | 24095018 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay, IC50 = 0.87 μM. | 24095018 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 14.9 μM. | 24095019 | ||
| HCT8 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay, IC50 = 6.54 μM. | 24095019 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 4.73 μM. | 24095019 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 11.52 μM. | 24095019 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50 = 1.1 μM. | 24106982 | ||
| KB-S15 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB-S15 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50 = 3.5 μM. | 24106982 | ||
| KB-VIN10 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB-VIN10 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50 = 23 μM. | 24106982 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 3.2 μM. | 24140948 | ||
| HCT8 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay, IC50 = 7.06 μM. | 24140948 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.91 μM. | 24140948 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by cell counting kit-8 assay, IC50 = 1.15 μM. | 24140948 | ||
| A549 | Growth inhibition assay | 72 hrs | Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50 = 2 μM. | 24180210 | ||
| Hs683 | Growth inhibition assay | 72 hrs | Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, IC50 = 2 μM. | 24180210 | ||
| MCF7 | Growth inhibition assay | 72 hrs | Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, IC50 = 4 μM. | 24180210 | ||
| SK-MEL-28 | Growth inhibition assay | 72 hrs | Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, IC50 = 3 μM. | 24180210 | ||
| U373 | Growth inhibition assay | 72 hrs | Growth inhibition of human U373 cells after 72 hrs by MTT assay, IC50 = 25 μM. | 24180210 | ||
| HBL100 | Growth inhibition assay | 48 hrs | Growth inhibition of human HBL100 cells after 48 hrs by SRB assay, GI50 = 1.4 μM. | 24211632 | ||
| HeLa | Growth inhibition assay | 48 hrs | Growth inhibition of human HeLa cells after 48 hrs by SRB assay, GI50 = 3.3 μM. | 24211632 | ||
| SW1573 | Growth inhibition assay | 48 hrs | Growth inhibition of human SW1573 cells after 48 hrs by SRB assay, GI50 = 15 μM. | 24211632 | ||
| T47D | Growth inhibition assay | 48 hrs | Growth inhibition of human T47D cells after 48 hrs by SRB assay, GI50 = 22 μM. | 24211632 | ||
| WiDr | Growth inhibition assay | 48 hrs | Growth inhibition of human WiDr cells after 48 hrs by SRB assay, GI50 = 23 μM. | 24211632 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTS assay, IC50 = 1 μM. | 24328269 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 2.58 μM. | 24332656 | ||
| DU145 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human DU145 cells after 72 hrs by sulforhodamine B assay, IC50 = 2.03 μM. | 24332656 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay, IC50 = 3.88 μM. | 24332656 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 4.46 μM. | 24389510 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 31.62 μM. | 24389510 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 19.95 μM. | 24389510 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 0.63 μM. | 24389510 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay relative to untreated control, TGI = 3.98 μM. | 24389510 | ||
| RWPE1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human RWPE1 cells after 72 hrs by MTT assay relative to untreated control, GI50 = 0.9 μM. | 24389510 | ||
| RWPE1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human RWPE1 cells after 72 hrs by MTT assay relative to untreated control, TGI = 4.8 μM. | 24389510 | ||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells by MTT assay, IC50 = 0.0057 μM. | 24422592 | |||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 4.71 μM. | 24487188 | ||
| HT-29 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 21.45 μM. | 24487188 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 23.9 μM. | 24487188 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 24.22 μM. | 24487188 | ||
| ME180 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human ME180 cells after 48 hrs by MTT assay, IC50 = 8.9 μM. | 24487188 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells after 48 hrs by MTT assay, IC50 = 14.4 μM. | 24487188 | ||
| DLD1 | Growth inhibition assay | 72 hrs | Growth inhibition of human DLD1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay, IC50 = 20 μM. | 24527835 | ||
| HeLa | Growth inhibition assay | 72 hrs | Growth inhibition of human HeLa cells assessed as inhibition of cell viability after 72 hrs by MTT assay, IC50 = 16 μM. | 24527835 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by SRB assay, IC50 = 2.58 μM. | 24553146 | ||
| DU145 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human DU145 cells after 72 hrs by SRB assay, IC50 = 2.03 μM. | 24553146 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by SRB assay, IC50 = 3.88 μM. | 24553146 | ||
| KB | Cytotoxicity assay | 72 hrs | Cytotoxicity against human KB cells after 72 hrs by methylene blue assay, IC50 = 1.5 μM. | 24657567 | ||
| KB-S15 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human vincristine/paclitaxel-resistant KB-S15 cells overexpressing P-gp170 after 72 hrs by methylene blue assay, IC50 = 3.5 μM. | 24657567 | ||
| KB-VIN10 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human vincristine/paclitaxel-resistant KB-VIN10 cells overexpressing P-gp170 after 72 hrs by methylene blue assay, IC50 = 26.4 μM. | 24657567 | ||
| KB-7d | Cytotoxicity assay | 72 hrs | Cytotoxicity against human VP16-resistant KB-7d cells overexpressing MRP after 72 hrs by methylene blue assay, IC50 = 46.1 μM. | 24657567 | ||
| A549 | Anticancer assay | 48 hrs | Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.45 μM. | 24721832 | ||
| ACHN | Anticancer assay | 48 hrs | Anticancer activity against human ACHN cells after 48 hrs by MTT assay, IC50 = 2.04 μM. | 24721832 | ||
| DU145 | Anticancer assay | 48 hrs | Anticancer activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 3.17 μM. | 24721832 | ||
| HeLa | Anticancer assay | 48 hrs | Anticancer activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.75 μM. | 24721832 | ||
| HT-29 | Anticancer assay | 48 hrs | Anticancer activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.47 μM. | 24721832 | ||
| BGC823 | Cytotoxicity assay | Cytotoxicity against human BGC823 cells, IC50 = 25.72 μM. | 24775914 | |||
| BGC823 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay, IC50 = 30.74 μM. | 24775914 | ||
| HepG2 | Cytotoxicity assay | Cytotoxicity against human HepG2 cells, IC50 = 1.15 μM. | 24775914 | |||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 15.32 μM. | 24775914 | ||
| HL-7702 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL-7702 cells after 48 hrs by MTT assay, IC50 = 24.61 μM. | 24775914 | ||
| H460 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human H460 cells after 72 hrs by MTT assay, IC50 = 0.1 μM. | 24780599 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 5 μM. | 24780599 | ||
| MCF7 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 1 μM. | 24780599 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 30.16 μM. | 24836071 | ||
| MOLT3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MOLT3 cells after 48 hrs by MTT assay, IC50 = 0.051 μM. | 24836071 | ||
| EPG85-257P | Antiproliferative assay | 5 days | Antiproliferative activity against human EPG85-257P cells after 5 days by sulforhodamine B assay, IC50 = 0.105 μM. | 24864039 | ||
| EPG85-257RD | Antiproliferative assay | 5 days | Antiproliferative activity against human EPG85-257RD cells after 5 days by sulforhodamine B assay, IC50 = 6.2 μM. | 24864039 | ||
| EPG85-257RN | Antiproliferative assay | 5 days | Antiproliferative activity against human EPG85-257RN cells after 5 days by sulforhodamine B assay, IC50 = 1.55 μM. | 24864039 | ||
| EPP85-181P | Antiproliferative assay | 5 days | Antiproliferative activity against human EPP85-181P cells after 5 days by sulforhodamine B assay, IC50 = 0.58 μM. | 24864039 | ||
| EPP85-181RN | Antiproliferative assay | 5 days | Antiproliferative activity against human EPP85-181RN cells after 5 days by sulforhodamine B assay, IC50 = 4.5 μM. | 24864039 | ||
| HT-29 | Antiproliferative assay | 5 days | Antiproliferative activity against human HT-29 cells after 5 days by sulforhodamine B assay, IC50 = 2.3 μM. | 24864039 | ||
| HT-29RD | Antiproliferative assay | 5 days | Antiproliferative activity against human HT-29RD cells after 5 days by sulforhodamine B assay, IC50 = 26 μM. | 24864039 | ||
| HT-29RN | Antiproliferative assay | 5 days | Antiproliferative activity against human HT-29RN cells after 5 days by sulforhodamine B assay, IC50 = 35 μM. | 24864039 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days, IC50 = 13.85 μM. | 24904965 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days, IC50 = 9.45 μM. | 24904965 | ||
| MCF10A | Cytotoxicity assay | 2 days | Cytotoxicity against human MCF10A cells after 2 days, IC50 = 12.23 μM. | 24904965 | ||
| T47D | Cytotoxicity assay | 2 days | Cytotoxicity against human T47D cells after 2 days, IC50 = 2.57 μM. | 24904965 | ||
| A549 | Growth inhibition assay | 72 hrs | Growth inhibition of human A549 cells after 72 hrs by MTT assay, IC50 = 0.1 μM. | 24950030 | ||
| Hs683 | Growth inhibition assay | 72 hrs | Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, IC50 = 1 μM. | 24950030 | ||
| MCF7 | Growth inhibition assay | 72 hrs | Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, IC50 = 17 μM. | 24950030 | ||
| PC3 | Growth inhibition assay | 72 hrs | Growth inhibition of human PC3 cells after 72 hrs by MTT assay, IC50 = 2 μM. | 24950030 | ||
| SK-MEL-28 | Growth inhibition assay | 72 hrs | Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, IC50 = 1 μM. | 24950030 | ||
| U373 | Growth inhibition assay | 72 hrs | Growth inhibition of human U373 cells after 72 hrs by MTT assay, IC50 = 7 μM. | 24950030 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50 = 0.6 μM. | 25014747 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 20.389 μM. | 25019480 | ||
| MOLT3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MOLT3 cells after 48 hrs by MTT assay, IC50 = 0.051 μM. | 25019480 | ||
| KB | Antiproliferative assay | Antiproliferative activity against human KB cells, IC50 = 1.1 μM. | 25059503 | |||
| KB-S15 | Antiproliferative assay | Antiproliferative activity against human KB-S15 cells, IC50 = 3.5 μM. | 25059503 | |||
| KB-VIN10 | Antiproliferative assay | Antiproliferative activity against human KB-VIN10 cells, IC50 = 23 μM. | 25059503 | |||
| HEK293 | Cytotoxicity assay | 4 days | Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay, IC50 = 1.04 μM. | 25062006 | ||
| DU145 | Cytotoxicity assay | 4 days | Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay, IC50 = 0.001 μM. | 25062006 | ||
| HCT15 | Cytotoxicity assay | 4 days | Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay, IC50 = 7.74 μM. | 25062006 | ||
| T47D | Cytotoxicity assay | 4 days | Cytotoxicity against human T47D cells after 4 days by CCK-8 assay, IC50 = 8.74 μM. | 25062006 | ||
| Vero | Cytotoxicity assay | 48 hrs | Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay, LC50 = 28 μM. | 25078313 | ||
| HEK293 | Cytotoxicity assay | 48 hrs | Cytotoxicity against HEK293 cells after 48 hrs by MTT assay, LC50 = 18 μM. | 25078313 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 6.27 μM. | 25113878 | ||
| K562 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 3.39 μM. | 25113878 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 0.62 μM. | 25131956 | ||
| MCF7 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 0.25 μM. | 25131956 | ||
| MIAPaCa2 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 1.1 μM. | 25131956 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 13.78 μM. | 25240702 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay, IC50 = 4.36 μM. | 25240702 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50 = 3.67 μM. | 25240702 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50 = 9.3 μM. | 25402632 | ||
| HCT15 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay, IC50 = 4.6 μM. | 25402632 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 3.4 μM. | 25402632 | ||
| HepG2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50 = 3.6 μM. | 25402632 | ||
| U373 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human U373 cells after 72 hrs by MTT assay, IC50 = 8.5 μM. | 25402632 | ||
| ZR-7530 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human ZR-7530 cells after 72 hrs by MTT assay, IC50 = 2.5 μM. | 25402632 | ||
| SKMES1 | Cytotoxicity assay | Cytotoxicity against human SKMES1 cells, IC50 = 1.83 μM. | 25440884 | |||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 4.71 μM. | 25453799 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 23.9 μM. | 25453799 | ||
| ME180 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human ME180 cells after 72 hrs by MTT assay, IC50 = 8.9 μM. | 25453799 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50 = 14.4 μM. | 25453799 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 10.12 μM. | 25462233 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 5.48 μM. | 25462233 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by Alamar Blue assay, IC50 = 2.87 μM. | 25466187 | ||
| L6 | Cytotoxicity assay | 71.5 hrs | Cytotoxicity against rat L6 cells after 71.5 hrs by Presto Blue assay, IC50 = 18.99 μM. | 25466187 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay, IC50 = 0.5 μM. | 25481396 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay, IC50 = 1.1 μM. | 25481396 | ||
| HeLa | Cytotoxicity assay | 2 days | Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay, IC50 = 1.26 μM. | 25481396 | ||
| MCF7 | Cytotoxicity assay | 2 days | Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay, IC50 = 0.73 μM. | 25481396 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.8 μM. | 25495422 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B assay, IC50 = 1.9 μM. | 25495422 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B assay, IC50 = 3.1 μM. | 25495422 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50 = 10.6 μM. | 25495422 | ||
| SKHEP1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKHEP1 cells after 72 hrs by sulforhodamine B assay, IC50 = 1.1 μM. | 25495422 | ||
| SNU638 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SNU638 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.5 μM. | 25495422 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 8.91 μM. | 25599951 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 0.54 μM. | 25599951 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.06 μM. | 25599951 | ||
| K562 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 1.64 μM. | 25599951 | ||
| A549 | Anticancer assay | 48 hrs | Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 3.01 μM. | 25615796 | ||
| DU145 | Anticancer assay | 48 hrs | Anticancer activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 1.98 μM. | 25615796 | ||
| HeLa | Anticancer assay | 48 hrs | Anticancer activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 3.23 μM. | 25615796 | ||
| HepG2 | Anticancer assay | 48 hrs | Anticancer activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 2.45 μM. | 25615796 | ||
| MCF7 | Anticancer assay | 48 hrs | Anticancer activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 2.69 μM. | 25615796 | ||
| HepG2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.4 μM. | 25644672 | ||
| MDA-MB-468 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 6.69 μM. | 25644672 | ||
| THP1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.82 μM. | 25644672 | ||
| U937 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.1 μM. | 25644672 | ||
| EL4 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse EL4 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 4.9 μM. | 25644672 | ||
| N9 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse N9 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 1.95 μM. | 25644672 | ||
| RAW264.7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 0.82 μM. | 25644672 | ||
| S17 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse S17 cells assessed as reduction in cell viability after 72 hrs by MTT colorimetric assay, IC50 = 10.4 μM. | 25644672 | ||
| A549 | Antiproliferative assay | 3 days | Antiproliferative activity against human A549 cells after 3 days by sulforhodamine B assay, IC50 = 0.8 μM. | 25700232 | ||
| HCT116 | Antiproliferative assay | 3 days | Antiproliferative activity against human HCT116 cells after 3 days by sulforhodamine B assay, IC50 = 1.9 μM. | 25700232 | ||
| K562 | Antiproliferative assay | 3 days | Antiproliferative activity against human K562 cells after 3 days by sulforhodamine B assay, IC50 = 3.1 μM. | 25700232 | ||
| MDA-MB-231 | Antiproliferative assay | 3 days | Antiproliferative activity against human MDA-MB-231 cells after 3 days by sulforhodamine B assay, IC50 = 11 μM. | 25700232 | ||
| SKHEP1 | Antiproliferative assay | 3 days | Antiproliferative activity against human SKHEP1 cells after 3 days by sulforhodamine B assay, IC50 = 1.1 μM. | 25700232 | ||
| SNU638 | Antiproliferative assay | 3 days | Antiproliferative activity against human SNU638 cells after 3 days by sulforhodamine B assay, IC50 = 0.5 μM. | 25700232 | ||
| A549 | Anticancer assay | 48 hrs | Anticancer activity against human A549 cells after 48 hrs by MTT assay, IC50 = 11.92 μM. | 25744190 | ||
| HL60 | Anticancer assay | 48 hrs | Anticancer activity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.31 μM. | 25744190 | ||
| MCF7 | Anticancer assay | 48 hrs | Anticancer activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 32.82 μM. | 25744190 | ||
| SMMC7721 | Anticancer assay | 48 hrs | Anticancer activity against human SMMC7721 cells after 48 hrs by MTT assay, IC50 = 8.12 μM. | 25744190 | ||
| SW480 | Anticancer assay | 48 hrs | Anticancer activity against human SW480 cells after 48 hrs by MTT assay, IC50 = 17.11 μM. | 25744190 | ||
| HepG2 | Cytotoxicity assay | Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 40.47 μM. | 25747499 | |||
| MOLT3 | Cytotoxicity assay | Cytotoxicity against human MOLT3 cells by XTT assay, IC50 = 0.11 μM. | 25747499 | |||
| CCRF-CEM | Cytotoxicity assay | 72 hrs | Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay, GI50 = 1.6 μM. | 25792142 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.6 μM. | 25792142 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.9 μM. | 25792142 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, GI50 = 0.6 μM. | 25792142 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, TGI = 4 μM. | 25792142 | ||
| DU145 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50 = 0.4 μM. | 25799376 | ||
| PC3 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay, IC50 = 4.33 μM. | 25799376 | ||
| U937 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human U937 cells after 24 hrs by MTT assay, IC50 = 1.5 μM. | 25800433 | ||
| MDA-MB-435 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-435 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 2.81 μM. | 25800514 | ||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 7.6 μM. | 25847767 | |||
| MDA-MB-231 | Cytotoxicity assay | Cytotoxicity against human MDA-MB-231 cells by MTT assay, IC50 = 10.3 μM. | 25847767 | |||
| T47D | Cytotoxicity assay | Cytotoxicity against human T47D cells by MTT assay, IC50 = 8.9 μM. | 25847767 | |||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by trypan blue staining-based hemocytometric analysis, GI50 = 0.4 μM. | 25874335 | ||
| HBL100 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay, GI50 = 1.9 μM. | 25899335 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay, GI50 = 2 μM. | 25899335 | ||
| SW1573 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay, GI50 = 3 μM. | 25899335 | ||
| T47D | Antiproliferative assay | 48 hrs | Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay, GI50 = 15 μM. | 25899335 | ||
| WiDr | Antiproliferative assay | 48 hrs | Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay, GI50 = 26 μM. | 25899335 | ||
| K/VP.5 | Cytotoxicity assay | 72 hrs | Cytotoxicity against etoposide-resistant human K/VP.5 cells assessed as cell growth inhibition after 72 hrs by MTS assay, IC50 = 2.5 μM. | 25922181 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells assessed as cell growth inhibition after 72 hrs by MTS assay, IC50 = 0.163 μM. | 25922181 | ||
| DU145 | Cytotoxicity assay | 4 days | Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay, IC50 = 2.09 μM. | 25936262 | ||
| HCT15 | Cytotoxicity assay | 4 days | Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay, IC50 = 18.87 μM. | 25936262 | ||
| HeLa | Cytotoxicity assay | 4 days | Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay, IC50 = 7.32 μM. | 25936262 | ||
| T47D | Cytotoxicity assay | 4 days | Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay, IC50 = 13.7 μM. | 25936262 | ||
| NALM6 | Cytotoxicity assay | 5 days | Cytotoxicity against human NALM6 cells expressing 50% TOP2A assessed as growth inhibition after 5 days by XTT assay, IC50 = 0.234 μM. | 25945730 | ||
| NALM6 | Cytotoxicity assay | 5 days | Cytotoxicity against TOP2B double knockout human NALM6 cells assessed as growth inhibition after 5 days by XTT assay, IC50 = 0.182 μM. | 25945730 | ||
| NALM6 | Cytotoxicity assay | 5 days | Cytotoxicity against wild type human NALM6 cells assessed as growth inhibition after 5 days by XTT assay, IC50 = 0.134 μM. | 25945730 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 0.4 μM. | 26010585 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 1.9 μM. | 26010585 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 7.7 μM. | 26010585 | ||
| SKHEP1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKHEP1 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 2.8 μM. | 26010585 | ||
| SNU638 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SNU638 cells assessed as inhibition of cell proliferation after 72 hrs by sulforhodamine B assay, IC50 = 0.3 μM. | 26010585 | ||
| DU145 | Cytotoxicity assay | 2 to 4 days | Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 0.5 μM. | 26022080 | ||
| HCT15 | Cytotoxicity assay | 2 to 4 days | Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 1.1 μM. | 26022080 | ||
| HeLa | Cytotoxicity assay | 2 to 4 days | Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 1.41 μM. | 26022080 | ||
| T47D | Cytotoxicity assay | 2 to 4 days | Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay, IC50 = 0.7 μM. | 26022080 | ||
| KB | Antiproliferative assay | 72 hrs | Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay, IC50 = 1.5 μM. | 26160020 | ||
| KB-7d | Antiproliferative assay | 72 hrs | Antiproliferative activity against human KB-7d cells expressing MRP after 72 hrs by methylene blue assay, IC50 = 46.1 μM. | 26160020 | ||
| KB-S15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human KB-S15 cells expressing P-gp170/MDR after 72 hrs by methylene blue assay, IC50 = 3.5 μM. | 26160020 | ||
| KB-VIN10 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human KB-VIN10 cells expressing P-gp170/MDR after 72 hrs by methylene blue assay, IC50 = 26.4 μM. | 26160020 | ||
| A549 | Antiproliferative assay | Antiproliferative activity against human A549 cells by MTT assay, IC50 = 18.2 μM. | 26216018 | |||
| HepG2 | Antiproliferative assay | Antiproliferative activity against human HepG2 cells by MTT assay, IC50 = 20.9 μM. | 26216018 | |||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by Hoechst assay, IC50 = 0.48 μM. | 26225905 | ||
| DLD1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DLD1 cells assessed as inhibition of cell growth incubated for 48 hrs by Hoechst assay, IC50 = 3.3 μM. | 26225905 | ||
| HepG2 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay, IC50 = 30 μM. | 26291037 | ||
| MDA-MB-231 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay, IC50 = 3.6 μM. | 26291037 | ||
| MDA-MB-435 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by SRB assay, IC50 = 1.7 μM. | 26291037 | ||
| PC3 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay, IC50 = 1 μM. | 26291037 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 38.5 μM. | 26292628 | ||
| DU145 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 5.21 μM. | 26292628 | ||
| HGC | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HGC cells after 48 hrs by MTT assay, IC50 = 10.9 μM. | 26292628 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 49.35 μM. | 26292628 | ||
| RWPE1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human RWPE1 cells after 48 hrs by MTT assay, IC50 = 27.64 μM. | 26292628 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay, IC50 = 5.54 μM. | 26334499 | ||
| HeLa | Cytotoxicity assay | 2 days | Cytotoxicity against human HeLa cells measured after 2 days by MTT assay, IC50 = 7.6 μM. | 26334499 | ||
| T47D | Cytotoxicity assay | 2 days | Cytotoxicity against human T47D cells measured after 2 days by MTT assay, IC50 = 9.28 μM. | 26334499 | ||
| GBM2 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human GBM2 cells assessed as reduction in cell viability incubated for 72 hrs by WST-1 method, IC50 = 1.1 μM. | 26355532 | ||
| DU145 | Cytotoxicity assay | 2 days | Cytotoxicity against human DU145 cells after 2 days by CCK8 assay, IC50 = 13.1 μM. | 26361737 | ||
| HCT15 | Cytotoxicity assay | 2 days | Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay, IC50 = 2.6 μM. | 26361737 | ||
| MCF10A | Cytotoxicity assay | 2 days | Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay, IC50 = 10.14 μM. | 26361737 | ||
| T47D | Cytotoxicity assay | 2 days | Cytotoxicity against human T47D cells after 2 days by CCK8 assay, IC50 = 0.94 μM. | 26361737 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 33.98 μM. | 26397393 | ||
| MOLT3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MOLT3 cells after 48 hrs by XTT assay, IC50 = 0.041 μM. | 26397393 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by resazurin assay, IC50 = 1.7 μM. | 26592897 | ||
| DLD1 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DLD1 cells assessed as growth inhibition after 48 hrs by resazurin assay, IC50 = 2 μM. | 26592897 | ||
| A549 | Antiproliferative assay | 24 to 72 hrs | Antiproliferative activity against human A549 cells after 24 to 72 hrs by SRB assay, IC50 = 0.8 μM. | 26595875 | ||
| CAKI-1 | Antiproliferative assay | 24 to 72 hrs | Antiproliferative activity against human CAKI-1 cells after 24 to 72 hrs by SRB assay, IC50 = 1.1 μM. | 26595875 | ||
| HCT116 | Antiproliferative assay | 24 to 72 hrs | Antiproliferative activity against human HCT116 cells after 24 to 72 hrs by SRB assay, IC50 = 3.3 μM. | 26595875 | ||
| HCT116 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HCT116 cells assessed as cell viability after 48 hrs by SRB assay, IC50 = 2.3 μM. | 26595875 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 0.3 μM. | 26595875 | ||
| K562 | Antiproliferative assay | 24 to 72 hrs | Antiproliferative activity against human K562 cells after 24 to 72 hrs by SRB assay, IC50 = 6.7 μM. | 26595875 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against p53-expressing human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 1.1 μM. | 26595875 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against p53-null human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 3.1 μM. | 26595875 | ||
| A549 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 2.675 μM. | 26615886 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 1.605 μM. | 26615886 | ||
| HepG2 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 1.748 μM. | 26615886 | ||
| K562 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 0.413 μM. | 26615886 | ||
| K562/ADR | Antiproliferative assay | 72 hrs | Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay, IC50 = 2.025 μM. | 26615886 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 26.1 μM. | 26618211 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 3.2 μM. | 26618211 | ||
| MDA-MB-231 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by SRB assay, IC50 = 4.2 μM. | 26618211 | ||
| A549 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 6.74 μM. | 26649766 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 32.45 μM. | 26649766 | ||
| HL60 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.16 μM. | 26649766 | ||
| HL60/MX2 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HL60/MX2 cells after 48 hrs by MTT assay, IC50 = 9.02 μM. | 26649766 | ||
| K562 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human K562 cells after 48 hrs by MTT assay, IC50 = 0.51 μM. | 26649766 | ||
| MDA-MB-201 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MDA-MB-201 cells after 48 hrs by MTT assay, IC50 = 31.33 μM. | 26649766 | ||
| Raji | Antiproliferative assay | 48 hrs | Antiproliferative activity against human Raji cells after 48 hrs by MTT assay, IC50 = 1.68 μM. | 26649766 | ||
| HEK293 | Cytotoxicity assay | 48 hrs | Cytotoxicity against HEK293 cells after 48 hrs by MTT assay, IC50 = 0.69 μM. | 26649766 | ||
| GM07492A | Cytotoxicity assay | 24 hrs | Cytotoxicity against human GM07492A cells assessed as cell growth inhibition after 24 hrs by XTT assay, IC50 = 1.2 μM. | 26649907 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 1.74 μM. | 26706168 | ||
| HCT15 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay, IC50 = 2.95 μM. | 26706168 | ||
| SK-MEL-2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay, IC50 = 1.33 μM. | 26706168 | ||
| SKOV3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay, IC50 = 1.96 μM. | 26706168 | ||
| HT-29 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay, IC50 = 2.2 μM. | 26731300 | ||
| MCF7 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay, IC50 = 0.8 μM. | 26731300 | ||
| PC3 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human PC3 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay, IC50 = 1.1 μM. | 26731300 | ||
| T84 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay, IC50 = 3 μM. | 26731300 | ||
| A375 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by ATPlite assay, IC50 = 0.24 μM. | 26793989 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by ATPlite assay, IC50 = 0.59 μM. | 26793989 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by ATPlite assay, IC50 = 0.86 μM. | 26793989 | ||
| HCT116 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 1.7 μM. | 26804229 | ||
| HepG2 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 5.62 μM. | 26804229 | ||
| A549 | Cytotoxicity assay | Cytotoxicity in human A549 cells by SRB assay, IC50 = 1.4 μM. | 26812172 | |||
| HCT116 | Cytotoxicity assay | Cytotoxicity in human HCT116 cells by SRB assay, IC50 = 1 μM. | 26812172 | |||
| SK-MEL-2 | Cytotoxicity assay | Cytotoxicity in human SK-MEL-2 cells by SRB assay, IC50 = 1.5 μM. | 26812172 | |||
| SKOV3 | Cytotoxicity assay | Cytotoxicity in human SKOV3 cells by SRB assay, IC50 = 2.6 μM. | 26812172 | |||
| 22Rv1 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human 22Rv1 cells after 96 hrs by propidium iodide-based monolayer assay, IC50 = 0.364 μM. | 26854430 | ||
| MCF7 | Antiproliferative assay | 96 hrs | Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay, IC50 = 1.264 μM. | 26854430 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 23.94 μM. | 26873416 | ||
| HCT8 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 10.89 μM. | 26873416 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 12.12 μM. | 26873416 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 27.07 μM. | 26873416 | ||
| WI38 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 35.8 μM. | 26873416 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 12.4 μM. | 26890115 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 15.7 μM. | 26890115 | ||
| T47D | Cytotoxicity assay | 48 hrs | Cytotoxicity against human T47D cells after 48 hrs by MTT assay, IC50 = 11.8 μM. | 26890115 | ||
| K562 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human K562 cells assessed as reduction in viable cells after 48 hrs by MTT assay, IC50 = 4.39 μM. | 26916436 | ||
| HONE1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HONE1 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 1.2 μM. | 26920801 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 2 μM. | 26920801 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 2.2 μM. | 26920801 | ||
| P388 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse P388 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 1.3 μM. | 26920801 | ||
| HCT15 | Cytotoxicity assay | 3 days | Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay, IC50 = 2.82 μM. | 26927425 | ||
| HeLa | Cytotoxicity assay | 3 days | Cytotoxicity against human HeLa cells after 3 days by CCK8 assay, IC50 = 0.18 μM. | 26927425 | ||
| T47D | Cytotoxicity assay | 3 days | Cytotoxicity against human T47D cells after 3 days by CCK8 assay, IC50 = 1.84 μM. | 26927425 | ||
| DU145 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay, IC50 = 2.09 μM. | 26945111 | ||
| HCT15 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay, IC50 = 18.87 μM. | 26945111 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay, IC50 = 7.32 μM. | 26945111 | ||
| T47D | Cytotoxicity assay | 48 hrs | Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay, IC50 = 13.7 μM. | 26945111 | ||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells by SRB assay, IC50 = 1.85 μM. | 26988298 | |||
| SK-MEL-2 | Cytotoxicity assay | Cytotoxicity against human SK-MEL-2 cells by SRB assay, IC50 = 1.17 μM. | 26988298 | |||
| SKOV3 | Cytotoxicity assay | Cytotoxicity against human SKOV3 cells by SRB assay, IC50 = 0.84 μM. | 26988298 | |||
| XF498 | Cytotoxicity assay | Cytotoxicity against human XF498 cells by SRB assay, IC50 = 1.72 μM. | 26988298 | |||
| BT474 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay, IC50 = 6.6 μM. | 26988802 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 6.9 μM. | 26988802 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 6.4 μM. | 26988802 | ||
| A549 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 3.82 μM. | 27060757 | ||
| CCRF-CEM | Antiproliferative assay | 48 hrs | Antiproliferative activity against human CCRF-CEM cells after 48 hrs by MTT assay, IC50 = 0.12 μM. | 27060757 | ||
| HCT116 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay, IC50 = 6.03 μM. | 27060757 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 41.21 μM. | 27060757 | ||
| A375 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50 = 0.24 μM. | 27096049 | ||
| A549 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50 = 0.59 μM. | 27096049 | ||
| HL60 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay, IC50 = 0.86 μM. | 27096049 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.5 μM. | 27145162 | ||
| MOLT3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MOLT3 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.7 μM. | 27145162 | ||
| HL60 | Cytotoxicity assay | Cytotoxicity against human HL60 cells assessed as reduction in cell survival, IC50 = 0.025 μM. | 27234147 | |||
| HEK293T | Cytotoxicity assay | 36 hrs | Cytotoxicity against HEK293T cells after 36 hrs by MTT assay, IC50 = 11.47 μM. | 27262599 | ||
| A549 | Cytotoxicity assay | 36 hrs | Cytotoxicity against human A549 cells after 36 hrs by MTT assay, IC50 = 8.01 μM. | 27262599 | ||
| HeLa | Cytotoxicity assay | 36 hrs | Cytotoxicity against human HeLa cells after 36 hrs by MTT assay, IC50 = 4.39 μM. | 27262599 | ||
| MCF7 | Cytotoxicity assay | 36 hrs | Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay, IC50 = 1.74 μM. | 27262599 | ||
| HEK293 | Anticlonogenic assay | 48 hrs | Anticlonogenic activity against HEK293 cells assessed as inhibition of colony formation incubated for 48 hrs measured after 6 days by crystal violet staining based assay, LC50 = 20 μM. | 27343852 | ||
| HEK293 | Cytotoxicity assay | 48 hrs | Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay, LC50 = 22 μM. | 27343852 | ||
| H460 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human H460 cells after 72 hrs by MTT assay, IC50 = 0.1 μM. | 27448912 | ||
| HCT116 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay, IC50 = 5 μM. | 27448912 | ||
| MCF7 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 1 μM. | 27448912 | ||
| shGFP-fused HMLE | Antiproliferative assay | 72 hrs | Antiproliferative activity against human shGFP-fused HMLE cells after 72 hrs by MTT assay, IC50 = 0.4 μM. | 27448912 | ||
| HCT15 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 1.06 μM. | 27484510 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 10.03 μM. | 27484510 | ||
| NCI-N87 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 1.29 μM. | 27484510 | ||
| T47D | Cytotoxicity assay | 72 hrs | Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay, IC50 = 2.8 μM. | 27484510 | ||
| K562 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human K562 cells measured after 72 hrs by CCK8 assay, IC50 = 0.345 μM. | 27484511 | ||
| K562/ADR | Antiproliferative assay | 72 hrs | Antiproliferative activity against human K562/ADR cells measured after 72 hrs by CCK8 assay, IC50 = 2.211 μM. | 27484511 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay, IC50 = 29.7 μM. | 27517805 | ||
| HCT8 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT8 cells measured after 48 hrs by MTT assay, IC50 = 10 μM. | 27517805 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells measured after 48 hrs by MTT assay, IC50 = 13.5 μM. | 27517805 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay, IC50 = 5.21 μM. | 27517805 | ||
| WI38 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human WI38 cells measured after 48 hrs by MTT assay, IC50 = 17.6 μM. | 27517805 | ||
| HEK293 | Cytotoxicity assay | 24 hrs | Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 24 hrs by MTT assay, IC50 = 0.6 μM. | 27533261 | ||
| H1975-1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human H1975-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 9.5 μM. | 27560280 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 8.2 μM. | 27560280 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 2.1 μM. | 27560280 | ||
| Vero | Cytotoxicity assay | 72 hrs | Cytotoxicity against human Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 1.5 μM. | 27560280 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against resistant human HCT116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay, IC50 = 2.8 μM. | 27560280 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50 = 0.3 μM. | 27598828 | ||
| HEK293 | Antiproliferative assay | 72 hrs | Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay, IC50 = 1.74 μM. | 27643560 | ||
| DU145 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay, IC50 = 0.02 μM. | 27643560 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 1.1 μM. | 27643560 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 0.18 μM. | 27643560 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 1.84 μM. | 27643560 | ||
| DU145 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay, IC50 = 2.19 μM. | 27654394 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay, IC50 = 1.27 μM. | 27654394 | ||
| MCF7 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay, IC50 = 35.55 μM. | 27654394 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay, IC50 = 4.85 μM. | 27654394 | ||
| HepG2 | Cytotoxicity assay | Cytotoxicity against human HepG2 cells by MTT assay, IC50 = 15.8 μM. | 27759375 | |||
| HBL100 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HBL100 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 1.4 μM. | 27765506 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 3.3 μM. | 27765506 | ||
| SW1573 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SW1573 cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 15 μM. | 27765506 | ||
| WiDr | Cytotoxicity assay | 48 hrs | Cytotoxicity against human WiDr cells assessed as growth inhibition after 48 hrs by SRB assay, GI50 = 23 μM. | 27765506 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 27.41 μM. | 27863370 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 13.35 μM. | 27863370 | ||
| T47D | Cytotoxicity assay | 72 hrs | Cytotoxicity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 9.8 μM. | 27863370 | ||
| HEK293T | Cytotoxicity assay | 48 hrs | Cytotoxicity against HEK293T cells assessed as cells growth inhibition after 48 hrs by MTT assay, IC50 = 22 μM. | 27994737 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by SRB assay, GI50 = 0.56 μM. | 28041801 | ||
| TK10 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay, GI50 = 7.19 μM. | 28041801 | ||
| TK10 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay, TGI = 49.74 μM. | 28041801 | ||
| UACC62 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human UACC62 cells assessed as cell growth inhibition after 48 hrs by SRB assay, GI50 = 0.89 μM. | 28041801 | ||
| HCT116 | Cytotoxicity assay | Cytotoxicity against human HCT116 cells assessed as growth inhibition by MTS assay, IC50 = 0.49 μM. | 28055208 | |||
| THP1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 1.82 μM. | 28062194 | ||
| U937 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 1.1 μM. | 28062194 | ||
| EL4 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse EL4 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 4.9 μM. | 28062194 | ||
| S17 | Cytotoxicity assay | 72 hrs | Cytotoxicity against mouse S17 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 10.4 μM. | 28062194 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 5.87 μM. | 28068602 | ||
| DU145 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 3.1 μM. | 28068602 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 20.3 μM. | 28068602 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 13.9 μM. | 28068602 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 5.4 μM. | 28068603 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 9.1 μM. | 28068603 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 7 μM. | 28068603 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by Cell Titer-Glo assay, EC50 = 15.9 μM. | 28080063 | ||
| HEK293 | Antiproliferative assay | 48 hrs | Antiproliferative activity against HEK293 cells after 48 hrs by SRB assay, IC50 = 7.51 μM. | 28094224 | ||
| DLD1 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human DLD1 cells after 48 hrs by SRB assay, IC50 = 8.11 μM. | 28094224 | ||
| DU145 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human DU145 cells after 48 hrs by SRB assay, IC50 = 10.64 μM. | 28094224 | ||
| FADU | Antiproliferative assay | 48 hrs | Antiproliferative activity against human FADU cells after 48 hrs by SRB assay, IC50 = 16.01 μM. | 28094224 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 0.92 μM. | 28165740 | ||
| BT549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human BT549 cells after 48 hrs by SRB assay, IC50 = 1.24 μM. | 28165740 | ||
| SK-MEL-2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay, IC50 = 1.1 μM. | 28165740 | ||
| SKOV3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay, IC50 = 1.95 μM. | 28165740 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 0.83 μM. | 28169166 | ||
| LO2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 3.78 μM. | 28169166 | ||
| SMMC7721 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay, IC50 = 0.15 μM. | 28169166 | ||
| HCT15 | Antiproliferative assay | 24 hrs | Antiproliferative activity against human HCT15 cells after 24 hrs by WST-1 assay, IC50 = 19.7 μM. | 28181805 | ||
| HeLaS3 | Antiproliferative assay | 24 hrs | Antiproliferative activity against human HeLaS3 cells after 24 hrs by WST-1 assay, IC50 = 43.1 μM. | 28181805 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 1.33 μM. | 28384547 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 3.2 μM. | 28384547 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 3.25 μM. | 28384547 | ||
| Vero | Cytotoxicity assay | 72 hrs | Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 16 μM. | 28385594 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 3 μM. | 28385594 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 8 μM. | 28385594 | ||
| HL60 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 20 μM. | 28385594 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells assessed as decrease in cell viability after 72 hrs by MTT assay, IC50 = 12 μM. | 28385594 | ||
| A549 | Growth inhibition assay | 72 hrs | Growth inhibition of human A549 cells after 72 hrs by MTT assay, GI50 = 1.7 μM. | 28406636 | ||
| Hs683 | Growth inhibition assay | 72 hrs | Growth inhibition of human Hs683 cells after 72 hrs by MTT assay, GI50 = 1.5 μM. | 28406636 | ||
| MCF7 | Growth inhibition assay | 72 hrs | Growth inhibition of human MCF7 cells after 72 hrs by MTT assay, GI50 = 4 μM. | 28406636 | ||
| SK-MEL-28 | Growth inhibition assay | 72 hrs | Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay, GI50 = 3.2 μM. | 28406636 | ||
| U373 | Growth inhibition assay | 72 hrs | Growth inhibition of human U373 cells after 72 hrs by MTT assay, GI50 = 24.9 μM. | 28406636 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50 = 7.89 μM. | 28431878 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 29.27 μM. | 28431878 | ||
| SMMC7721 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 40.44 μM. | 28431878 | ||
| A549 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 19.83 μM. | 28462840 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 15.93 μM. | 28462840 | ||
| MCF7 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 24.01 μM. | 28462840 | ||
| MGC803 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay, IC50 = 20.91 μM. | 28462840 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 14.7 μM. | 28512026 | ||
| HCT8 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay, IC50 = 26.3 μM. | 28512026 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 24.9 μM. | 28512026 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 13.4 μM. | 28512026 | ||
| WI38 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human WI38 cells after 48 hrs by MTT assay, IC50 = 46.9 μM. | 28512026 | ||
| A549 | Cytotoxicity assay | Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay, IC50 = 16.6 μM. | 28571311 | |||
| HeLa | Cytotoxicity assay | Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay, IC50 = 15 μM. | 28571311 | |||
| HepG2 | Cytotoxicity assay | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay, IC50 = 16.1 μM. | 28571311 | |||
| A549 | Growth inhibition assay | 72 hrs | Growth inhibition of human A549 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 0.3 μM. | 28625715 | ||
| HCT116 | Growth inhibition assay | 72 hrs | Growth inhibition of human HCT116 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 1.06 μM. | 28625715 | ||
| K562 | Growth inhibition assay | 72 hrs | Growth inhibition of human K562 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 0.76 μM. | 28625715 | ||
| MDA-MB-231 | Growth inhibition assay | 72 hrs | Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 1.53 μM. | 28625715 | ||
| MRC5 | Growth inhibition assay | 72 hrs | Growth inhibition of human MRC5 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 11.73 μM. | 28625715 | ||
| SKHEP1 | Growth inhibition assay | 72 hrs | Growth inhibition of human SKHEP1 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 0.63 μM. | 28625715 | ||
| SNU638 | Growth inhibition assay | 72 hrs | Growth inhibition of human SNU638 cells incubated for 72 hrs by sulforhodamine B assay, IC50 = 1.05 μM. | 28625715 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay, IC50 = 9.27 μM. | 28633898 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay, IC50 = 4.12 μM. | 28633898 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay, IC50 = 8.81 μM. | 28633898 | ||
| HeLa | Cytotoxicity assay | 72 hrs | Cytotoxic activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 7.21 μM. | 28733083 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxic activity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50 = 16.27 μM. | 28733083 | ||
| SMMC7721 | Cytotoxicity assay | 72 hrs | Cytotoxic activity against human SMMC7721 cells after 72 hrs by MTT assay, IC50 = 21.03 μM. | 28733083 | ||
| A549 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human A549 cells after 24 hrs by MTT assay, IC50 = 6.21 μM. | 28757065 | ||
| HeLa | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay, IC50 = 1.58 μM. | 28757065 | ||
| HepG2 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay, IC50 = 5.52 μM. | 28757065 | ||
| L02 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human L02 cells after 24 hrs by MTT assay, IC50 = 7.75 μM. | 28757065 | ||
| MCF7 | Cytotoxicity assay | 24 hrs | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay, IC50 = 2.08 μM. | 28757065 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by SRB assay, IC50 = 1.1 μM. | 28841320 | ||
| BT549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human BT549 cells after 48 hrs by SRB assay, IC50 = 1 μM. | 28841320 | ||
| SK-MEL-2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay, IC50 = 0.2 μM. | 28841320 | ||
| SKOV3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay, IC50 = 2.9 μM. | 28841320 | ||
| MCF7 | Cytotoxicity assay | Cytotoxicity against human MCF7 cells by MTT assay, IC50 = 12.4 μM. | 28886509 | |||
| SK-MEL-1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SK-MEL-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50 = 8 μM. | 29032930 | ||
| HeLaS3 | Antiproliferative assay | Antiproliferative activity against human HeLaS3 cells by MTT assay, IC50 = 0.5 μM. | 29072457 | |||
| HT-29 | Antiproliferative assay | Antiproliferative activity against human HT-29 cells by MTT assay, IC50 = 7.6 μM. | 29072457 | |||
| A549 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50 = 1.3 μM. | 29077404 | ||
| DU145 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay, IC50 = 1 μM. | 29077404 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, IC50 = 2.4 μM. | 29077404 | ||
| MCF7 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, IC50 = 10.5 μM. | 29077404 | ||
| A549 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human A549 cells after 48 hrs by SRB assay, GI50 = 1.5 μM. | 29129514 | ||
| HBL100 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay, GI50 = 2.3 μM. | 29129514 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay, GI50 = 3 μM. | 29129514 | ||
| SW1573 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay, GI50 = 15 μM. | 29129514 | ||
| T47D | Antiproliferative assay | 48 hrs | Antiproliferative activity against human T47D cells after 48 hrs by SRB assay, GI50 = 22 μM. | 29129514 | ||
| WiDr | Antiproliferative assay | 48 hrs | Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay, GI50 = 23 μM. | 29129514 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 9.1 μM. | 29248296 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 11.2 μM. | 29248296 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 9.2 μM. | 29248296 | ||
| LoVo | Cytotoxicity assay | 48 hrs | Cytotoxicity against human LoVo cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 18.7 μM. | 29248296 | ||
| WI38 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human WI38 cells assessed as reduction in inhibition of cell growth incubated for 48 hrs by MTT assay, IC50 = 25.7 μM. | 29248296 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.03 μM. | 29269253 | ||
| DU145 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 2.03 μM. | 29269253 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.03 μM. | 29269253 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 2.03 μM. | 29269253 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 2.27 μM. | 29289881 | ||
| DU145 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay, IC50 = 1.97 μM. | 29289881 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 1.93 μM. | 29289881 | ||
| HT-29 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.64 μM. | 29289881 | ||
| MDA-MB-231 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50 = 1.91 μM. | 29289881 | ||
| A549 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50 = 1.97 μM. | 29289884 | ||
| DU145 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay, IC50 = 2.35 μM. | 29289884 | ||
| HeLa | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay, IC50 = 2.71 μM. | 29289884 | ||
| HepG2 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 2.84 μM. | 29289884 | ||
| HT-29 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay, IC50 = 1.87 μM. | 29289884 | ||
| MCF7 | Antiproliferative assay | 48 hrs | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50 = 1.62 μM. | 29289884 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 32.61 μM. | 29335211 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 22.35 μM. | 29335211 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 0.19 μM. | 29335211 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay, IC50 = 5.73 μM. | 29335211 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay, IC50 = 2.94 μM. | 29402741 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay, IC50 = 9.21 μM. | 29402741 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay, IC50 = 0.4 μM. | 29402741 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay, IC50 = 2.45 μM. | 29510948 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay, IC50 = 10.03 μM. | 29510948 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay, IC50 = 0.32 μM. | 29510948 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 3.25 μM. | 29525336 | ||
| DU145 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 2.13 μM. | 29525336 | ||
| HCT116 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 2.6 μM. | 29525336 | ||
| HT-29 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HT-29 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 1.8 μM. | 29525336 | ||
| MCF7 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 2.03 μM. | 29525336 | ||
| PC3 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay, IC50 = 5.4 μM. | 29525336 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 13.71 μM. | 29545100 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 32.05 μM. | 29545100 | ||
| HL60 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay, IC50 = 0.33 μM. | 29545100 | ||
| K562 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human K562 cells after 48 hrs by MTT assay, IC50 = 8.45 μM. | 29545100 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human etoposide-sensitive K562 cells after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay, IC50 = 1.22 μM. | 29656990 | ||
| HT-29 | Cytotoxicity assay | 24 to 72 hrs | Cytotoxicity against human HT-29 cells measured after 24 to 72 hrs by SRB assay, IC50 = 15 μM. | 29656990 | ||
| K/VP.5 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K/VP.5 cells after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay, IC50 = 35.36 μM. | 29656990 | ||
| OVCAR3 | Cytotoxicity assay | 24 to 72 hrs | Cytotoxicity against human OVCAR3 cells measured after 24 to 72 hrs by SRB assay, IC50 = 2.9 μM. | 29656990 | ||
| CCRF-CEM | Cytotoxicity assay | 72 hrs | Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 1.26 μM. | 29670691 | ||
| HT-29 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 31.62 μM. | 29670691 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 12.59 μM. | 29670691 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 19.95 μM. | 29670691 | ||
| PC3 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay, GI50 = 0.63 μM. | 29670691 | ||
| K562 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay, IC50 = 0.764 μM. | 29678463 | ||
| K562/VCR | Antiproliferative assay | 72 hrs | Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay, IC50 = 11.84 μM. | 29678463 | ||
| HepG2 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay, IC50 = 20.1 μM. | 29778894 | ||
| K562 | Antiproliferative assay | Antiproliferative activity against human K562 cells, IC50 = 0.3 μM. | 29871847 | |||
| K/VP.5 | Function assay | Inhibition of human topoisomerase-2 in etoposide-resistant K/VP.5 cells assessed as growth inhibition, IC50 = 5.1 μM. | 29871847 | |||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 9.4695 μM. | 29886322 | ||
| L02 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human L02 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 3.4805 μM. | 29886322 | ||
| MCF7 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay, IC50 = 4.7165 μM. | 29886322 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.72 μM. | 29893558 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.68 μM. | 29893558 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B assay, IC50 = 1.3 μM. | 29893558 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, IC50 = 4.4 μM. | 29893558 | ||
| SKHEP1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKHEP1 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.93 μM. | 29893558 | ||
| SNU638 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SNU638 cells after 72 hrs by sulforhodamine B assay, IC50 = 0.43 μM. | 29893558 | ||
| A549 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 0.3 μM. | 30041947 | ||
| HCT116 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 1.06 μM. | 30041947 | ||
| K562 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 0.76 μM. | 30041947 | ||
| MDA-MB-231 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 1.53 μM. | 30041947 | ||
| MRC5 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human MRC5 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 11.73 μM. | 30041947 | ||
| SKHEP1 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 0.63 μM. | 30041947 | ||
| SNU638 | Cytotoxicity assay | 72 hrs | Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay, IC50 = 1.05 μM. | 30041947 | ||
| CCRF-CEM | Antiproliferative assay | 72 hrs | Antiproliferative activity against human CCRF-CEM cells after 72 hrs by MTT assay, GI50 = 1.6 μM. | 30071406 | ||
| HT-29 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, GI50 = 31.6 μM. | 30071406 | ||
| MCF7 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay, GI50 = 19.9 μM. | 30071406 | ||
| PC3 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, GI50 = 0.6 μM. | 30071406 | ||
| PC3 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, TGI = 4 μM. | 30071406 | ||
| HCT15 | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay, IC50 = 2.94 μM. | 30262132 | ||
| HeLa | Antiproliferative assay | 72 hrs | Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay, IC50 = 9.21 μM. | 30262132 | ||
| T47D | Antiproliferative assay | 72 hrs | Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay, IC50 = 0.4 μM. | 30262132 | ||
| A549 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50 = 22.5 μM. | 30265994 | ||
| HeLa | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay, IC50 = 21.4 μM. | 30265994 | ||
| HepG2 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay, IC50 = 20 μM. | 30265994 | ||
| HL7702 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human HL7702 cells after 48 hrs by MTT assay, IC50 = 24.6 μM. | 30265994 | ||
| MRC5 | Cytotoxicity assay | 48 hrs | Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay, IC50 = 33.5 μM. | 30265994 | ||
| RH-1 | Growth inhibition assay | IC50 = 0.01778 μM | SANGER | |||
| A253 | Growth inhibition assay | IC50 = 0.01843 μM | SANGER | |||
| HT-144 | Growth inhibition assay | IC50 = 0.02009 μM | SANGER | |||
| EW-16 | Growth inhibition assay | IC50 = 0.02148 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth inhibition assay | IC50 = 0.02502 μM | SANGER | |||
| KE-37 | Growth inhibition assay | IC50 = 0.04072 μM | SANGER | |||
| SK-UT-1 | Growth inhibition assay | IC50 = 0.04237 μM | SANGER | |||
| OCUB-M | Growth inhibition assay | IC50 = 0.04455 μM | SANGER | |||
| 8-MG-BA | Growth inhibition assay | IC50 = 0.04687 μM | SANGER | |||
| TE-9 | Growth inhibition assay | IC50 = 0.05593 μM | SANGER | |||
| CGTH-W-1 | Growth inhibition assay | IC50 = 0.05741 μM | SANGER | |||
| BB30-HNC | Growth inhibition assay | IC50 = 0.06418 μM | SANGER | |||
| ACN | Growth inhibition assay | IC50 = 0.07896 μM | SANGER | |||
| EW-13 | Growth inhibition assay | IC50 = 0.08885 μM | SANGER | |||
| DU-4475 | Growth inhibition assay | IC50 = 0.09615 μM | SANGER | |||
| HGC-27 | Growth inhibition assay | IC50 = 0.10212 μM | SANGER | |||
| A427 | Growth inhibition assay | IC50 = 0.10338 μM | SANGER | |||
| HT-1080 | Growth inhibition assay | IC50 = 0.10853 μM | SANGER | |||
| MC-IXC | Growth inhibition assay | IC50 = 0.11512 μM | SANGER | |||
| MRK-nu-1 | Growth inhibition assay | IC50 = 0.1162 μM | SANGER | |||
| EW-7 | Growth inhibition assay | IC50 = 0.12506 μM | SANGER | |||
| SW982 | Growth inhibition assay | IC50 = 0.13069 μM | SANGER | |||
| SIG-M5 | Growth inhibition assay | IC50 = 0.13082 μM | SANGER | |||
| PA-1 | Growth inhibition assay | IC50 = 0.13219 μM | SANGER | |||
| ES8 | Growth inhibition assay | IC50 = 0.14221 μM | SANGER | |||
| MV-4-11 | Growth inhibition assay | IC50 = 0.15121 μM | SANGER | |||
| QIMR-WIL | Growth inhibition assay | IC50 = 0.15458 μM | SANGER | |||
| COLO-679 | Growth inhibition assay | IC50 = 0.16303 μM | SANGER | |||
| CCRF-CEM | Growth inhibition assay | IC50 = 0.17043 μM | SANGER | |||
| IGROV-1 | Growth inhibition assay | IC50 = 0.17072 μM | SANGER | |||
| LOUCY | Growth inhibition assay | IC50 = 0.1766 μM | SANGER | |||
| ML-2 | Growth inhibition assay | IC50 = 0.17847 μM | SANGER | |||
| RS4-11 | Growth inhibition assay | IC50 = 0.19612 μM | SANGER | |||
| DJM-1 | Growth inhibition assay | IC50 = 0.20294 μM | SANGER | |||
| ATN-1 | Growth inhibition assay | IC50 = 0.20386 μM | SANGER | |||
| NALM-6 | Growth inhibition assay | IC50 = 0.20584 μM | SANGER | |||
| HUTU-80 | Growth inhibition assay | IC50 = 0.21676 μM | SANGER | |||
| REH | Growth inhibition assay | IC50 = 0.22424 μM | SANGER | |||
| NCI-H2030 | Growth inhibition assay | IC50 = 0.22992 μM | SANGER | |||
| A204 | Growth inhibition assay | IC50 = 0.23248 μM | SANGER | |||
| NCI-H460 | Growth inhibition assay | IC50 = 0.23571 μM | SANGER | |||
| 697 | Growth inhibition assay | IC50 = 0.2432 μM | SANGER | |||
| KYSE-270 | Growth inhibition assay | IC50 = 0.25188 μM | SANGER | |||
| ES1 | Growth inhibition assay | IC50 = 0.25434 μM | SANGER | |||
| COLO-205 | Growth inhibition assay | IC50 = 0.26497 μM | SANGER | |||
| SK-HEP-1 | Growth inhibition assay | IC50 = 0.26712 μM | SANGER | |||
| RPMI-8402 | Growth inhibition assay | IC50 = 0.27109 μM | SANGER | |||
| H4 | Growth inhibition assay | IC50 = 0.29654 μM | SANGER | |||
| LU-134-A | Growth inhibition assay | IC50 = 0.29919 μM | SANGER | |||
| EoL-1-cell | Growth inhibition assay | IC50 = 0.30172 μM | SANGER | |||
| SBC-5 | Growth inhibition assay | IC50 = 0.30262 μM | SANGER | |||
| DEL | Growth inhibition assay | IC50 = 0.31149 μM | SANGER | |||
| P12-ICHIKAWA | Growth inhibition assay | IC50 = 0.31679 μM | SANGER | |||
| AGS | Growth inhibition assay | IC50 = 0.31823 μM | SANGER | |||
| KS-1 | Growth inhibition assay | IC50 = 0.33444 μM | SANGER | |||
| SK-PN-DW | Growth inhibition assay | IC50 = 0.34228 μM | SANGER | |||
| DOHH-2 | Growth inhibition assay | IC50 = 0.34733 μM | SANGER | |||
| KGN | Growth inhibition assay | IC50 = 0.35189 μM | SANGER | |||
| A3-KAW | Growth inhibition assay | IC50 = 0.35826 μM | SANGER | |||
| M059J | Growth inhibition assay | IC50 = 0.36401 μM | SANGER | |||
| Daoy | Growth inhibition assay | IC50 = 0.36773 μM | SANGER | |||
| MKN1 | Growth inhibition assay | IC50 = 0.38169 μM | SANGER | |||
| CESS | Growth inhibition assay | IC50 = 0.38386 μM | SANGER | |||
| SW620 | Growth inhibition assay | IC50 = 0.38448 μM | SANGER | |||
| NCI-H1355 | Growth inhibition assay | IC50 = 0.38972 μM | SANGER | |||
| EB2 | Growth inhibition assay | IC50 = 0.39146 μM | SANGER | |||
| ABC-1 | Growth inhibition assay | IC50 = 0.40453 μM | SANGER | |||
| GT3TKB | Growth inhibition assay | IC50 = 0.40644 μM | SANGER | |||
| CTV-1 | Growth inhibition assay | IC50 = 0.40969 μM | SANGER | |||
| VA-ES-BJ | Growth inhibition assay | IC50 = 0.41481 μM | SANGER | |||
| KP-4 | Growth inhibition assay | IC50 = 0.41615 μM | SANGER | |||
| MOLT-4 | Growth inhibition assay | IC50 = 0.41754 μM | SANGER | |||
| NKM-1 | Growth inhibition assay | IC50 = 0.42516 μM | SANGER | |||
| A2058 | Growth inhibition assay | IC50 = 0.42537 μM | SANGER | |||
| BFTC-905 | Growth inhibition assay | IC50 = 0.42621 μM | SANGER | |||
| SR | Growth inhibition assay | IC50 = 0.44265 μM | SANGER | |||
| NCI-H526 | Growth inhibition assay | IC50 = 0.45612 μM | SANGER | |||
| MES-SA | Growth inhibition assay | IC50 = 0.45821 μM | SANGER | |||
| MHH-ES-1 | Growth inhibition assay | IC50 = 0.46271 μM | SANGER | |||
| IMR-5 | Growth inhibition assay | IC50 = 0.46935 μM | SANGER | |||
| RKO | Growth inhibition assay | IC50 = 0.47075 μM | SANGER | |||
| HOS | Growth inhibition assay | IC50 = 0.47376 μM | SANGER | |||
| 647-V | Growth inhibition assay | IC50 = 0.48734 μM | SANGER | |||
| 786-0 | Growth inhibition assay | IC50 = 0.4922 μM | SANGER | |||
| Calu-3 | Growth inhibition assay | IC50 = 0.49556 μM | SANGER | |||
| U251 | Growth inhibition assay | IC50 = 0.50083 μM | SANGER | |||
| 23132-87 | Growth inhibition assay | IC50 = 0.50139 μM | SANGER | |||
| BE-13 | Growth inhibition assay | IC50 = 0.50368 μM | SANGER | |||
| SW1710 | Growth inhibition assay | IC50 = 0.51838 μM | SANGER | |||
| ES4 | Growth inhibition assay | IC50 = 0.52145 μM | SANGER | |||
| HOP-62 | Growth inhibition assay | IC50 = 0.52437 μM | SANGER | |||
| MHH-NB-11 | Growth inhibition assay | IC50 = 0.52443 μM | SANGER | |||
| KYSE-150 | Growth inhibition assay | IC50 = 0.53039 μM | SANGER | |||
| ESS-1 | Growth inhibition assay | IC50 = 0.53078 μM | SANGER | |||
| HLE | Growth inhibition assay | IC50 = 0.53357 μM | SANGER | |||
| NEC8 | Growth inhibition assay | IC50 = 0.53895 μM | SANGER | |||
| HC-1 | Growth inhibition assay | IC50 = 0.54032 μM | SANGER | |||
| BC-1 | Growth inhibition assay | IC50 = 0.54533 μM | SANGER | |||
| SK-LMS-1 | Growth inhibition assay | IC50 = 0.5528 μM | SANGER | |||
| NCI-H2342 | Growth inhibition assay | IC50 = 0.55508 μM | SANGER | |||
| OCI-AML2 | Growth inhibition assay | IC50 = 0.55935 μM | SANGER | |||
| KYSE-510 | Growth inhibition assay | IC50 = 0.56639 μM | SANGER | |||
| HMV-II | Growth inhibition assay | IC50 = 0.56879 μM | SANGER | |||
| RPMI-2650 | Growth inhibition assay | IC50 = 0.57196 μM | SANGER | |||
| DMS-273 | Growth inhibition assay | IC50 = 0.57348 μM | SANGER | |||
| MC-CAR | Growth inhibition assay | IC50 = 0.57962 μM | SANGER | |||
| DU-145 | Growth inhibition assay | IC50 = 0.59125 μM | SANGER | |||
| HCC1599 | Growth inhibition assay | IC50 = 0.61627 μM | SANGER | |||
| RT-112 | Growth inhibition assay | IC50 = 0.62053 μM | SANGER | |||
| CAL-148 | Growth inhibition assay | IC50 = 0.62544 μM | SANGER | |||
| ES3 | Growth inhibition assay | IC50 = 0.62849 μM | SANGER | |||
| A375 | Growth inhibition assay | IC50 = 0.63084 μM | SANGER | |||
| SW872 | Growth inhibition assay | IC50 = 0.6404 μM | SANGER | |||
| LCLC-103H | Growth inhibition assay | IC50 = 0.6511 μM | SANGER | |||
| MEL-JUSO | Growth inhibition assay | IC50 = 0.6571 μM | SANGER | |||
| NH-12 | Growth inhibition assay | IC50 = 0.67198 μM | SANGER | |||
| NCI-H187 | Growth inhibition assay | IC50 = 0.67362 μM | SANGER | |||
| CAL-33 | Growth inhibition assay | IC50 = 0.6858 μM | SANGER | |||
| ALL-PO | Growth inhibition assay | IC50 = 0.68979 μM | SANGER | |||
| 8505C | Growth inhibition assay | IC50 = 0.69275 μM | SANGER | |||
| NCI-H2009 | Growth inhibition assay | IC50 = 0.69655 μM | SANGER | |||
| KURAMOCHI | Growth inhibition assay | IC50 = 0.6986 μM | SANGER | |||
| HSC-2 | Growth inhibition assay | IC50 = 0.70578 μM | SANGER | |||
| SUP-T1 | Growth inhibition assay | IC50 = 0.70586 μM | SANGER | |||
| GI-1 | Growth inhibition assay | IC50 = 0.71317 μM | SANGER | |||
| TUR | Growth inhibition assay | IC50 = 0.72224 μM | SANGER | |||
| PF-382 | Growth inhibition assay | IC50 = 0.72388 μM | SANGER | |||
| MEL-HO | Growth inhibition assay | IC50 = 0.72874 μM | SANGER | |||
| BCPAP | Growth inhibition assay | IC50 = 0.73695 μM | SANGER | |||
| MFH-ino | Growth inhibition assay | IC50 = 0.7513 μM | SANGER | |||
| ONS-76 | Growth inhibition assay | IC50 = 0.75429 μM | SANGER | |||
| MFE-296 | Growth inhibition assay | IC50 = 0.76297 μM | SANGER | |||
| NCI-H2087 | Growth inhibition assay | IC50 = 0.76306 μM | SANGER | |||
| LCLC-97TM1 | Growth inhibition assay | IC50 = 0.76624 μM | SANGER | |||
| ES7 | Growth inhibition assay | IC50 = 0.76713 μM | SANGER | |||
| A431 | Growth inhibition assay | IC50 = 0.79754 μM | SANGER | |||
| HCE-4 | Growth inhibition assay | IC50 = 0.80135 μM | SANGER | |||
| SK-MES-1 | Growth inhibition assay | IC50 = 0.80842 μM | SANGER | |||
| MZ1-PC | Growth inhibition assay | IC50 = 0.8111 μM | SANGER | |||
| ME-180 | Growth inhibition assay | IC50 = 0.8238 μM | SANGER | |||
| MCF7 | Growth inhibition assay | IC50 = 0.8305 μM | SANGER | |||
| G-361 | Growth inhibition assay | IC50 = 0.83387 μM | SANGER | |||
| ACHN | Growth inhibition assay | IC50 = 0.83874 μM | SANGER | |||
| A4-Fuk | Growth inhibition assay | IC50 = 0.84103 μM | SANGER | |||
| SCC-9 | Growth inhibition assay | IC50 = 0.84957 μM | SANGER | |||
| IST-SL2 | Growth inhibition assay | IC50 = 0.85003 μM | SANGER | |||
| CAL-62 | Growth inhibition assay | IC50 = 0.85117 μM | SANGER | |||
| C-33-A | Growth inhibition assay | IC50 = 0.86169 μM | SANGER | |||
| 5637 | Growth inhibition assay | IC50 = 0.86693 μM | SANGER | |||
| EFM-19 | Growth inhibition assay | IC50 = 0.86752 μM | SANGER | |||
| SW48 | Growth inhibition assay | IC50 = 0.86895 μM | SANGER | |||
| NCI-H748 | Growth inhibition assay | IC50 = 0.87069 μM | SANGER | |||
| CHL-1 | Growth inhibition assay | IC50 = 0.8829 μM | SANGER | |||
| G-402 | Growth inhibition assay | IC50 = 0.89819 μM | SANGER | |||
| LS-411N | Growth inhibition assay | IC50 = 0.92538 μM | SANGER | |||
| GCIY | Growth inhibition assay | IC50 = 0.92549 μM | SANGER | |||
| HuO9 | Growth inhibition assay | IC50 = 0.92578 μM | SANGER | |||
| BPH-1 | Growth inhibition assay | IC50 = 0.94282 μM | SANGER | |||
| ECC12 | Growth inhibition assay | IC50 = 0.95438 μM | SANGER | |||
| SU-DHL-1 | Growth inhibition assay | IC50 = 0.95915 μM | SANGER | |||
| TE-15 | Growth inhibition assay | IC50 = 0.95964 μM | SANGER | |||
| BB65-RCC | Growth inhibition assay | IC50 = 0.97887 μM | SANGER | |||
| NUGC-3 | Growth inhibition assay | IC50 = 0.98081 μM | SANGER | |||
| HCT-116 | Growth inhibition assay | IC50 = 1.00749 μM | SANGER | |||
| 639-V | Growth inhibition assay | IC50 = 1.00797 μM | SANGER | |||
| RPMI-6666 | Growth inhibition assay | IC50 = 1.03221 μM | SANGER | |||
| DoTc2-4510 | Growth inhibition assay | IC50 = 1.04831 μM | SANGER | |||
| L-540 | Growth inhibition assay | IC50 = 1.05791 μM | SANGER | |||
| NB12 | Growth inhibition assay | IC50 = 1.08357 μM | SANGER | |||
| CAL-51 | Growth inhibition assay | IC50 = 1.08397 μM | SANGER | |||
| NB69 | Growth inhibition assay | IC50 = 1.0875 μM | SANGER | |||
| OVCAR-8 | Growth inhibition assay | IC50 = 1.09145 μM | SANGER | |||
| A2780 | Growth inhibition assay | IC50 = 1.10527 μM | SANGER | |||
| RL95-2 | Growth inhibition assay | IC50 = 1.11034 μM | SANGER | |||
| HT-3 | Growth inhibition assay | IC50 = 1.12847 μM | SANGER | |||
| UM-UC-3 | Growth inhibition assay | IC50 = 1.14554 μM | SANGER | |||
| BFTC-909 | Growth inhibition assay | IC50 = 1.16148 μM | SANGER | |||
| SNG-M | Growth inhibition assay | IC50 = 1.16368 μM | SANGER | |||
| MG-63 | Growth inhibition assay | IC50 = 1.17999 μM | SANGER | |||
| TE-5 | Growth inhibition assay | IC50 = 1.18327 μM | SANGER | |||
| A101D | Growth inhibition assay | IC50 = 1.19812 μM | SANGER | |||
| NCI-H209 | Growth inhibition assay | IC50 = 1.20699 μM | SANGER | |||
| SCC-3 | Growth inhibition assay | IC50 = 1.21017 μM | SANGER | |||
| P30-OHK | Growth inhibition assay | IC50 = 1.21124 μM | SANGER | |||
| YKG-1 | Growth inhibition assay | IC50 = 1.22754 μM | SANGER | |||
| CAPAN-1 | Growth inhibition assay | IC50 = 1.24645 μM | SANGER | |||
| HCC2998 | Growth inhibition assay | IC50 = 1.25705 μM | SANGER | |||
| HSC-4 | Growth inhibition assay | IC50 = 1.26252 μM | SANGER | |||
| SAS | Growth inhibition assay | IC50 = 1.2672 μM | SANGER | |||
| COR-L279 | Growth inhibition assay | IC50 = 1.26744 μM | SANGER | |||
| FADU | Growth inhibition assay | IC50 = 1.28154 μM | SANGER | |||
| SK-LU-1 | Growth inhibition assay | IC50 = 1.28962 μM | SANGER | |||
| NCI-H1703 | Growth inhibition assay | IC50 = 1.29939 μM | SANGER | |||
| KASUMI-1 | Growth inhibition assay | IC50 = 1.32239 μM | SANGER | |||
| NCI-H1694 | Growth inhibition assay | IC50 = 1.37183 μM | SANGER | |||
| LK-2 | Growth inhibition assay | IC50 = 1.40757 μM | SANGER | |||
| CHP-212 | Growth inhibition assay | IC50 = 1.41096 μM | SANGER | |||
| HSC-3 | Growth inhibition assay | IC50 = 1.43589 μM | SANGER | |||
| G-401 | Growth inhibition assay | IC50 = 1.43693 μM | SANGER | |||
| SF126 | Growth inhibition assay | IC50 = 1.44086 μM | SANGER | |||
| HuP-T4 | Growth inhibition assay | IC50 = 1.45259 μM | SANGER | |||
| EW-1 | Growth inhibition assay | IC50 = 1.45847 μM | SANGER | |||
| MDA-MB-468 | Growth inhibition assay | IC50 = 1.46554 μM | SANGER | |||
| NCI-H1734 | Growth inhibition assay | IC50 = 1.50503 μM | SANGER | |||
| 22RV1 | Growth inhibition assay | IC50 = 1.53054 μM | SANGER | |||
| BHY | Growth inhibition assay | IC50 = 1.53169 μM | SANGER | |||
| OVCAR-5 | Growth inhibition assay | IC50 = 1.53748 μM | SANGER | |||
| EM-2 | Growth inhibition assay | IC50 = 1.57782 μM | SANGER | |||
| NCI-H810 | Growth inhibition assay | IC50 = 1.58283 μM | SANGER | |||
| IGR-1 | Growth inhibition assay | IC50 = 1.59112 μM | SANGER | |||
| J-RT3-T3-5 | Growth inhibition assay | IC50 = 1.59438 μM | SANGER | |||
| SF539 | Growth inhibition assay | IC50 = 1.60689 μM | SANGER | |||
| GB-1 | Growth inhibition assay | IC50 = 1.60936 μM | SANGER | |||
| SK-CO-1 | Growth inhibition assay | IC50 = 1.62804 μM | SANGER | |||
| BOKU | Growth inhibition assay | IC50 = 1.63222 μM | SANGER | |||
| PANC-03-27 | Growth inhibition assay | IC50 = 1.6369 μM | SANGER | |||
| SF295 | Growth inhibition assay | IC50 = 1.65606 μM | SANGER | |||
| COLO-668 | Growth inhibition assay | IC50 = 1.66431 μM | SANGER | |||
| KM-H2 | Growth inhibition assay | IC50 = 1.66942 μM | SANGER | |||
| C8166 | Growth inhibition assay | IC50 = 1.6773 μM | SANGER | |||
| CTB-1 | Growth inhibition assay | IC50 = 1.68766 μM | SANGER | |||
| NCI-H650 | Growth inhibition assay | IC50 = 1.70971 μM | SANGER | |||
| C-4-II | Growth inhibition assay | IC50 = 1.71356 μM | SANGER | |||
| NCI-H1650 | Growth inhibition assay | IC50 = 1.73565 μM | SANGER | |||
| NCI-SNU-1 | Growth inhibition assay | IC50 = 1.75327 μM | SANGER | |||
| SNU-423 | Growth inhibition assay | IC50 = 1.75342 μM | SANGER | |||
| COLO-829 | Growth inhibition assay | IC50 = 1.76857 μM | SANGER | |||
| SW13 | Growth inhibition assay | IC50 = 1.80203 μM | SANGER | |||
| NCI-H2170 | Growth inhibition assay | IC50 = 1.85285 μM | SANGER | |||
| MKN45 | Growth inhibition assay | IC50 = 1.87359 μM | SANGER | |||
| KM12 | Growth inhibition assay | IC50 = 1.87938 μM | SANGER | |||
| SN12C | Growth inhibition assay | IC50 = 1.88379 μM | SANGER | |||
| SK-NEP-1 | Growth inhibition assay | IC50 = 1.90148 μM | SANGER | |||
| HuCCT1 | Growth inhibition assay | IC50 = 1.91064 μM | SANGER | |||
| SW954 | Growth inhibition assay | IC50 = 1.96311 μM | SANGER | |||
| VMRC-RCZ | Growth inhibition assay | IC50 = 1.96786 μM | SANGER | |||
| HT-29 | Growth inhibition assay | IC50 = 1.97537 μM | SANGER | |||
| LB647-SCLC | Growth inhibition assay | IC50 = 2.00119 μM | SANGER | |||
| KU812 | Growth inhibition assay | IC50 = 2.03197 μM | SANGER | |||
| LoVo | Growth inhibition assay | IC50 = 2.06081 μM | SANGER | |||
| LC-2-ad | Growth inhibition assay | IC50 = 2.06407 μM | SANGER | |||
| KYSE-180 | Growth inhibition assay | IC50 = 2.06953 μM | SANGER | |||
| NCI-H1299 | Growth inhibition assay | IC50 = 2.0703 μM | SANGER | |||
| LXF-289 | Growth inhibition assay | IC50 = 2.07522 μM | SANGER | |||
| BL-41 | Growth inhibition assay | IC50 = 2.08098 μM | SANGER | |||
| COLO-800 | Growth inhibition assay | IC50 = 2.09855 μM | SANGER | |||
| LB1047-RCC | Growth inhibition assay | IC50 = 2.13516 μM | SANGER | |||
| OAW-28 | Growth inhibition assay | IC50 = 2.15234 μM | SANGER | |||
| CAL-85-1 | Growth inhibition assay | IC50 = 2.15944 μM | SANGER | |||
| A673 | Growth inhibition assay | IC50 = 2.16359 μM | SANGER | |||
| MZ2-MEL | Growth inhibition assay | IC50 = 2.17939 μM | SANGER | |||
| NOMO-1 | Growth inhibition assay | IC50 = 2.18798 μM | SANGER | |||
| Ca9-22 | Growth inhibition assay | IC50 = 2.18807 μM | SANGER | |||
| ARH-77 | Growth inhibition assay | IC50 = 2.18911 μM | SANGER | |||
| D-283MED | Growth inhibition assay | IC50 = 2.19537 μM | SANGER | |||
| AN3-CA | Growth inhibition assay | IC50 = 2.20226 μM | SANGER | |||
| ST486 | Growth inhibition assay | IC50 = 2.24988 μM | SANGER | |||
| SW1573 | Growth inhibition assay | IC50 = 2.25339 μM | SANGER | |||
| 769-P | Growth inhibition assay | IC50 = 2.25653 μM | SANGER | |||
| HCC38 | Growth inhibition assay | IC50 = 2.27106 μM | SANGER | |||
| RPMI-7951 | Growth inhibition assay | IC50 = 2.28584 μM | SANGER | |||
| HL-60 | Growth inhibition assay | IC50 = 2.29181 μM | SANGER | |||
| NCI-H1304 | Growth inhibition assay | IC50 = 2.30406 μM | SANGER | |||
| 8305C | Growth inhibition assay | IC50 = 2.32067 μM | SANGER | |||
| Ca-Ski | Growth inhibition assay | IC50 = 2.32829 μM | SANGER | |||
| DSH1 | Growth inhibition assay | IC50 = 2.36138 μM | SANGER | |||
| HEC-1 | Growth inhibition assay | IC50 = 2.3745 μM | SANGER | |||
| HO-1-N-1 | Growth inhibition assay | IC50 = 2.37868 μM | SANGER | |||
| TE-10 | Growth inhibition assay | IC50 = 2.38102 μM | SANGER | |||
| TYK-nu | Growth inhibition assay | IC50 = 2.41237 μM | SANGER | |||
| LU-99A | Growth inhibition assay | IC50 = 2.42772 μM | SANGER | |||
| NCI-H2405 | Growth inhibition assay | IC50 = 2.43564 μM | SANGER | |||
| BC-3 | Growth inhibition assay | IC50 = 2.47545 μM | SANGER | |||
| RERF-LC-MS | Growth inhibition assay | IC50 = 2.49413 μM | SANGER | |||
| JiyoyeP-2003 | Growth inhibition assay | IC50 = 2.5428 μM | SANGER | |||
| MKN28 | Growth inhibition assay | IC50 = 2.54669 μM | SANGER | |||
| SF268 | Growth inhibition assay | IC50 = 2.54745 μM | SANGER | |||
| HuH-7 | Growth inhibition assay | IC50 = 2.56377 μM | SANGER | |||
| VM-CUB-1 | Growth inhibition assay | IC50 = 2.57875 μM | SANGER | |||
| AU565 | Growth inhibition assay | IC50 = 2.61126 μM | SANGER | |||
| GAMG | Growth inhibition assay | IC50 = 2.61355 μM | SANGER | |||
| DBTRG-05MG | Growth inhibition assay | IC50 = 2.62832 μM | SANGER | |||
| NCI-H2228 | Growth inhibition assay | IC50 = 2.65509 μM | SANGER | |||
| MIA-PaCa-2 | Growth inhibition assay | IC50 = 2.6613 μM | SANGER | |||
| NCI-H1882 | Growth inhibition assay | IC50 = 2.67868 μM | SANGER | |||
| CMK | Growth inhibition assay | IC50 = 2.68446 μM | SANGER | |||
| ETK-1 | Growth inhibition assay | IC50 = 2.74528 μM | SANGER | |||
| NB13 | Growth inhibition assay | IC50 = 2.76358 μM | SANGER | |||
| PANC-10-05 | Growth inhibition assay | IC50 = 2.88779 μM | SANGER | |||
| UACC-62 | Growth inhibition assay | IC50 = 2.91997 μM | SANGER | |||
| SW756 | Growth inhibition assay | IC50 = 2.98046 μM | SANGER | |||
| SJSA-1 | Growth inhibition assay | IC50 = 2.98416 μM | SANGER | |||
| L-428 | Growth inhibition assay | IC50 = 2.98894 μM | SANGER | |||
| IST-MEL1 | Growth inhibition assay | IC50 = 2.99943 μM | SANGER | |||
| JEG-3 | Growth inhibition assay | IC50 = 3.04067 μM | SANGER | |||
| SW1783 | Growth inhibition assay | IC50 = 3.05871 μM | SANGER | |||
| BHT-101 | Growth inhibition assay | IC50 = 3.10736 μM | SANGER | |||
| SH-4 | Growth inhibition assay | IC50 = 3.1346 μM | SANGER | |||
| NCI-H358 | Growth inhibition assay | IC50 = 3.15154 μM | SANGER | |||
| LC4-1 | Growth inhibition assay | IC50 = 3.22759 μM | SANGER | |||
| GCT | Growth inhibition assay | IC50 = 3.26576 μM | SANGER | |||
| EGI-1 | Growth inhibition assay | IC50 = 3.27013 μM | SANGER | |||
| NMC-G1 | Growth inhibition assay | IC50 = 3.32432 μM | SANGER | |||
| A388 | Growth inhibition assay | IC50 = 3.32957 μM | SANGER | |||
| J82 | Growth inhibition assay | IC50 = 3.33987 μM | SANGER | |||
| NCI-H522 | Growth inhibition assay | IC50 = 3.35766 μM | SANGER | |||
| EFO-27 | Growth inhibition assay | IC50 = 3.35777 μM | SANGER | |||
| NCI-H1437 | Growth inhibition assay | IC50 = 3.38115 μM | SANGER | |||
| MLMA | Growth inhibition assay | IC50 = 3.38191 μM | SANGER | |||
| GDM-1 | Growth inhibition assay | IC50 = 3.40206 μM | SANGER | |||
| IA-LM | Growth inhibition assay | IC50 = 3.43569 μM | SANGER | |||
| no-10 | Growth inhibition assay | IC50 = 3.48873 μM | SANGER | |||
| NOS-1 | Growth inhibition assay | IC50 = 3.58057 μM | SANGER | |||
| HCC1569 | Growth inhibition assay | IC50 = 3.58372 μM | SANGER | |||
| FTC-133 | Growth inhibition assay | IC50 = 3.58908 μM | SANGER | |||
| AM-38 | Growth inhibition assay | IC50 = 3.66706 μM | SANGER | |||
| KYSE-450 | Growth inhibition assay | IC50 = 3.68871 μM | SANGER | |||
| ChaGo-K-1 | Growth inhibition assay | IC50 = 3.79409 μM | SANGER | |||
| HAL-01 | Growth inhibition assay | IC50 = 3.80443 μM | SANGER | |||
| NCI-H1770 | Growth inhibition assay | IC50 = 3.86539 μM | SANGER | |||
| HEL | Growth inhibition assay | IC50 = 3.89764 μM | SANGER | |||
| NCI-H64 | Growth inhibition assay | IC50 = 3.99787 μM | SANGER | |||
| LU-139 | Growth inhibition assay | IC50 = 4.00867 μM | SANGER | |||
| LS-123 | Growth inhibition assay | IC50 = 4.02035 μM | SANGER | |||
| Calu-6 | Growth inhibition assay | IC50 = 4.05854 μM | SANGER | |||
| KP-N-YS | Growth inhibition assay | IC50 = 4.23582 μM | SANGER | |||
| MZ7-mel | Growth inhibition assay | IC50 = 4.29859 μM | SANGER | |||
| KARPAS-422 | Growth inhibition assay | IC50 = 4.3292 μM | SANGER | |||
| IPC-298 | Growth inhibition assay | IC50 = 4.33485 μM | SANGER | |||
| NCI-H661 | Growth inhibition assay | IC50 = 4.34179 μM | SANGER | |||
| WSU-NHL | Growth inhibition assay | IC50 = 4.36044 μM | SANGER | |||
| HH | Growth inhibition assay | IC50 = 4.44423 μM | SANGER | |||
| NY | Growth inhibition assay | IC50 = 4.48988 μM | SANGER | |||
| BT-20 | Growth inhibition assay | IC50 = 4.5794 μM | SANGER | |||
| NCI-H1417 | Growth inhibition assay | IC50 = 4.60594 μM | SANGER | |||
| CAL-39 | Growth inhibition assay | IC50 = 4.63617 μM | SANGER | |||
| RPMI-8866 | Growth inhibition assay | IC50 = 4.64882 μM | SANGER | |||
| NCI-H292 | Growth inhibition assay | IC50 = 4.7095 μM | SANGER | |||
| SJRH30 | Growth inhibition assay | IC50 = 4.72366 μM | SANGER | |||
| HCC1806 | Growth inhibition assay | IC50 = 4.73101 μM | SANGER | |||
| MEG-01 | Growth inhibition assay | IC50 = 4.74917 μM | SANGER | |||
| EW-11 | Growth inhibition assay | IC50 = 4.76565 μM | SANGER | |||
| RD | Growth inhibition assay | IC50 = 4.80409 μM | SANGER | |||
| KYSE-140 | Growth inhibition assay | IC50 = 4.91746 μM | SANGER | |||
| NCI-H2081 | Growth inhibition assay | IC50 = 4.91765 μM | SANGER | |||
| HOP-92 | Growth inhibition assay | IC50 = 5.02277 μM | SANGER | |||
| BV-173 | Growth inhibition assay | IC50 = 5.05329 μM | SANGER | |||
| OE33 | Growth inhibition assay | IC50 = 5.12216 μM | SANGER | |||
| NCI-H1793 | Growth inhibition assay | IC50 = 5.30922 μM | SANGER | |||
| Daudi | Growth inhibition assay | IC50 = 5.36115 μM | SANGER | |||
| NCI-H2122 | Growth inhibition assay | IC50 = 5.39424 μM | SANGER | |||
| SW1990 | Growth inhibition assay | IC50 = 5.639 μM | SANGER | |||
| MS-1 | Growth inhibition assay | IC50 = 5.64297 μM | SANGER | |||
| HT-1376 | Growth inhibition assay | IC50 = 5.81886 μM | SANGER | |||
| GP5d | Growth inhibition assay | IC50 = 5.8311 μM | SANGER | |||
| OAW-42 | Growth inhibition assay | IC50 = 6.05896 μM | SANGER | |||
| LB831-BLC | Growth inhibition assay | IC50 = 6.15047 μM | SANGER | |||
| COR-L23 | Growth inhibition assay | IC50 = 6.18279 μM | SANGER | |||
| CP66-MEL | Growth inhibition assay | IC50 = 6.25378 μM | SANGER | |||
| CHP-126 | Growth inhibition assay | IC50 = 6.27397 μM | SANGER | |||
| GOTO | Growth inhibition assay | IC50 = 6.37509 μM | SANGER | |||
| DB | Growth inhibition assay | IC50 = 6.5298 μM | SANGER | |||
| L-363 | Growth inhibition assay | IC50 = 6.58998 μM | SANGER | |||
| SCC-25 | Growth inhibition assay | IC50 = 6.63406 μM | SANGER | |||
| CAKI-1 | Growth inhibition assay | IC50 = 6.65287 μM | SANGER | |||
| GR-ST | Growth inhibition assay | IC50 = 6.68733 μM | SANGER | |||
| Mewo | Growth inhibition assay | IC50 = 6.79226 μM | SANGER | |||
| MMAC-SF | Growth inhibition assay | IC50 = 6.87553 μM | SANGER | |||
| CCF-STTG1 | Growth inhibition assay | IC50 = 6.91149 μM | SANGER | |||
| NCI-H1563 | Growth inhibition assay | IC50 = 7.06829 μM | SANGER | |||
| BL-70 | Growth inhibition assay | IC50 = 7.07066 μM | SANGER | |||
| SCC-4 | Growth inhibition assay | IC50 = 7.20234 μM | SANGER | |||
| TE-11 | Growth inhibition assay | IC50 = 7.45503 μM | SANGER | |||
| TK10 | Growth inhibition assay | IC50 = 7.49225 μM | SANGER | |||
| NCI-H2196 | Growth inhibition assay | IC50 = 7.49486 μM | SANGER | |||
| no-11 | Growth inhibition assay | IC50 = 7.55794 μM | SANGER | |||
| HuO-3N1 | Growth inhibition assay | IC50 = 7.71346 μM | SANGER | |||
| HCT-15 | Growth inhibition assay | IC50 = 7.87059 μM | SANGER | |||
| Calu-1 | Growth inhibition assay | IC50 = 7.89022 μM | SANGER | |||
| NCI-SNU-5 | Growth inhibition assay | IC50 = 7.91903 μM | SANGER | |||
| C3A | Growth inhibition assay | IC50 = 7.93051 μM | SANGER | |||
| M14 | Growth inhibition assay | IC50 = 7.94538 μM | SANGER | |||
| KMOE-2 | Growth inhibition assay | IC50 = 8.03697 μM | SANGER | |||
| NCI-H520 | Growth inhibition assay | IC50 = 8.03907 μM | SANGER | |||
| NCI-H69 | Growth inhibition assay | IC50 = 8.18234 μM | SANGER | |||
| SK-MEL-30 | Growth inhibition assay | IC50 = 8.24405 μM | SANGER | |||
| COLO-680N | Growth inhibition assay | IC50 = 8.25621 μM | SANGER | |||
| Raji | Growth inhibition assay | IC50 = 8.31941 μM | SANGER | |||
| NCI-H2141 | Growth inhibition assay | IC50 = 8.52227 μM | SANGER | |||
| HD-MY-Z | Growth inhibition assay | IC50 = 8.53777 μM | SANGER | |||
| CaR-1 | Growth inhibition assay | IC50 = 8.60091 μM | SANGER | |||
| A172 | Growth inhibition assay | IC50 = 8.64964 μM | SANGER | |||
| NCI-H510A | Growth inhibition assay | IC50 = 8.65064 μM | SANGER | |||
| TE-8 | Growth inhibition assay | IC50 = 8.75118 μM | SANGER | |||
| T98G | Growth inhibition assay | IC50 = 8.81581 μM | SANGER | |||
| SIMA | Growth inhibition assay | IC50 = 8.85231 μM | SANGER | |||
| SW626 | Growth inhibition assay | IC50 = 8.90372 μM | SANGER | |||
| CAL-54 | Growth inhibition assay | IC50 = 8.92125 μM | SANGER | |||
| MDA-MB-231 | Growth inhibition assay | IC50 = 9.08645 μM | SANGER | |||
| NCI-H630 | Growth inhibition assay | IC50 = 9.12079 μM | SANGER | |||
| LAMA-84 | Growth inhibition assay | IC50 = 9.20893 μM | SANGER | |||
| COR-L105 | Growth inhibition assay | IC50 = 9.56953 μM | SANGER | |||
| NCI-H2347 | Growth inhibition assay | IC50 = 9.66391 μM | SANGER | |||
| SK-MM-2 | Growth inhibition assay | IC50 = 9.68223 μM | SANGER | |||
| PC-14 | Growth inhibition assay | IC50 = 9.72234 μM | SANGER | |||
| KG-1 | Growth inhibition assay | IC50 = 9.72465 μM | SANGER | |||
| COLO-320-HSR | Growth inhibition assay | IC50 = 9.73489 μM | SANGER | |||
| GI-ME-N | Growth inhibition assay | IC50 = 9.82616 μM | SANGER | |||
| KMS-12-PE | Growth inhibition assay | IC50 = 9.91106 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth inhibition assay | IC50 = 9.93808 μM | SANGER | |||
| HCC1954 | Growth inhibition assay | IC50 = 10.0429 μM | SANGER | |||
| SK-MEL-3 | Growth inhibition assay | IC50 = 10.1322 μM | SANGER | |||
| NB1 | Growth inhibition assay | IC50 = 10.2077 μM | SANGER | |||
| KLE | Growth inhibition assay | IC50 = 10.2925 μM | SANGER | |||
| KALS-1 | Growth inhibition assay | IC50 = 10.3029 μM | SANGER | |||
| NCI-H2126 | Growth inhibition assay | IC50 = 10.3993 μM | SANGER | |||
| CAL-27 | Growth inhibition assay | IC50 = 10.4443 μM | SANGER | |||
| SK-OV-3 | Growth inhibition assay | IC50 = 10.8274 μM | SANGER | |||
| SNB75 | Growth inhibition assay | IC50 = 10.9411 μM | SANGER | |||
| NCI-H1155 | Growth inhibition assay | IC50 = 11.02 μM | SANGER | |||
| Detroit562 | Growth inhibition assay | IC50 = 11.0755 μM | SANGER | |||
| CAL-12T | Growth inhibition assay | IC50 = 11.136 μM | SANGER | |||
| NCI-H226 | Growth inhibition assay | IC50 = 11.1518 μM | SANGER | |||
| NCI-H441 | Growth inhibition assay | IC50 = 11.166 μM | SANGER | |||
| OS-RC-2 | Growth inhibition assay | IC50 = 11.2175 μM | SANGER | |||
| U031 | Growth inhibition assay | IC50 = 11.2885 μM | SANGER | |||
| NCI-H2052 | Growth inhibition assay | IC50 = 11.4502 μM | SANGER | |||
| TCCSUP | Growth inhibition assay | IC50 = 11.6187 μM | SANGER | |||
| T47D | Growth inhibition assay | IC50 = 11.6637 μM | SANGER | |||
| Becker | Growth inhibition assay | IC50 = 11.8156 μM | SANGER | |||
| EFO-21 | Growth inhibition assay | IC50 = 11.8503 μM | SANGER | |||
| NCI-H1963 | Growth inhibition assay | IC50 = 12.0942 μM | SANGER | |||
| MONO-MAC-6 | Growth inhibition assay | IC50 = 12.1309 μM | SANGER | |||
| MOLT-16 | Growth inhibition assay | IC50 = 12.4619 μM | SANGER | |||
| U-698-M | Growth inhibition assay | IC50 = 12.4627 μM | SANGER | |||
| MDA-MB-157 | Growth inhibition assay | IC50 = 12.6094 μM | SANGER | |||
| KYSE-410 | Growth inhibition assay | IC50 = 12.8456 μM | SANGER | |||
| CAMA-1 | Growth inhibition assay | IC50 = 13.0046 μM | SANGER | |||
| SCC-15 | Growth inhibition assay | IC50 = 13.1497 μM | SANGER | |||
| NCI-H23 | Growth inhibition assay | IC50 = 13.1861 μM | SANGER | |||
| KNS-42 | Growth inhibition assay | IC50 = 13.6511 μM | SANGER | |||
| HDLM-2 | Growth inhibition assay | IC50 = 13.7938 μM | SANGER | |||
| NCI-H1623 | Growth inhibition assay | IC50 = 13.9776 μM | SANGER | |||
| RPMI-8226 | Growth inhibition assay | IC50 = 14.3243 μM | SANGER | |||
| EW-3 | Growth inhibition assay | IC50 = 14.3337 μM | SANGER | |||
| HT | Growth inhibition assay | IC50 = 15.2889 μM | SANGER | |||
| CAL-120 | Growth inhibition assay | IC50 = 15.6326 μM | SANGER | |||
| HCC1937 | Growth inhibition assay | IC50 = 15.7725 μM | SANGER | |||
| NCI-N87 | Growth inhibition assay | IC50 = 15.8106 μM | SANGER | |||
| NB10 | Growth inhibition assay | IC50 = 15.9987 μM | SANGER | |||
| UACC-812 | Growth inhibition assay | IC50 = 16.4249 μM | SANGER | |||
| MHH-PREB-1 | Growth inhibition assay | IC50 = 16.4817 μM | SANGER | |||
| SNU-449 | Growth inhibition assay | IC50 = 16.6657 μM | SANGER | |||
| COLO-684 | Growth inhibition assay | IC50 = 16.7953 μM | SANGER | |||
| BxPC-3 | Growth inhibition assay | IC50 = 16.8611 μM | SANGER | |||
| DMS-153 | Growth inhibition assay | IC50 = 16.9246 μM | SANGER | |||
| SW962 | Growth inhibition assay | IC50 = 16.9729 μM | SANGER | |||
| OVCAR-4 | Growth inhibition assay | IC50 = 17.3428 μM | SANGER | |||
| CAS-1 | Growth inhibition assay | IC50 = 17.5833 μM | SANGER | |||
| HPAF-II | Growth inhibition assay | IC50 = 17.6767 μM | SANGER | |||
| NCI-H838 | Growth inhibition assay | IC50 = 17.9844 μM | SANGER | |||
| D-247MG | Growth inhibition assay | IC50 = 18.052 μM | SANGER | |||
| T-24 | Growth inhibition assay | IC50 = 18.0868 μM | SANGER | |||
| YT | Growth inhibition assay | IC50 = 18.2712 μM | SANGER | |||
| NCI-H596 | Growth inhibition assay | IC50 = 18.2999 μM | SANGER | |||
| CPC-N | Growth inhibition assay | IC50 = 18.426 μM | SANGER | |||
| HN | Growth inhibition assay | IC50 = 18.5533 μM | SANGER | |||
| KARPAS-299 | Growth inhibition assay | IC50 = 19.2708 μM | SANGER | |||
| ES6 | Growth inhibition assay | IC50 = 19.6334 μM | SANGER | |||
| IST-SL1 | Growth inhibition assay | IC50 = 19.8912 μM | SANGER | |||
| LOXIMVI | Growth inhibition assay | IC50 = 19.9253 μM | SANGER | |||
| U-266 | Growth inhibition assay | IC50 = 19.9794 μM | SANGER | |||
| HCC2157 | Growth inhibition assay | IC50 = 20.3328 μM | SANGER | |||
| MPP-89 | Growth inhibition assay | IC50 = 20.7595 μM | SANGER | |||
| MDA-MB-361 | Growth inhibition assay | IC50 = 20.8051 μM | SANGER | |||
| RCM-1 | Growth inhibition assay | IC50 = 20.9952 μM | SANGER | |||
| SW780 | Growth inhibition assay | IC50 = 21.109 μM | SANGER | |||
| SK-MEL-2 | Growth inhibition assay | IC50 = 21.2698 μM | SANGER | |||
| TE-1 | Growth inhibition assay | IC50 = 21.4838 μM | SANGER | |||
| NB5 | Growth inhibition assay | IC50 = 21.8618 μM | SANGER | |||
| OVCAR-3 | Growth inhibition assay | IC50 = 22.2138 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth inhibition assay | IC50 = 23.5156 μM | SANGER | |||
| KYSE-520 | Growth inhibition assay | IC50 = 24.0956 μM | SANGER | |||
| UMC-11 | Growth inhibition assay | IC50 = 24.3195 μM | SANGER | |||
| NCCIT | Growth inhibition assay | IC50 = 24.4842 μM | SANGER | |||
| OPM-2 | Growth inhibition assay | IC50 = 24.6118 μM | SANGER | |||
| GAK | Growth inhibition assay | IC50 = 25.1015 μM | SANGER | |||
| PLC-PRF-5 | Growth inhibition assay | IC50 = 25.4198 μM | SANGER | |||
| K5 | Growth inhibition assay | IC50 = 25.5192 μM | SANGER | |||
| HT55 | Growth inhibition assay | IC50 = 25.82 μM | SANGER | |||
| HT-1197 | Growth inhibition assay | IC50 = 25.8682 μM | SANGER | |||
| Saos-2 | Growth inhibition assay | IC50 = 26.0963 μM | SANGER | |||
| NCI-H1648 | Growth inhibition assay | IC50 = 26.3623 μM | SANGER | |||
| NCI-H747 | Growth inhibition assay | IC50 = 27.2478 μM | SANGER | |||
| U-87-MG | Growth inhibition assay | IC50 = 27.5565 μM | SANGER | |||
| LU-165 | Growth inhibition assay | IC50 = 28.8005 μM | SANGER | |||
| Caov-3 | Growth inhibition assay | IC50 = 29.2228 μM | SANGER | |||
| MN-60 | Growth inhibition assay | IC50 = 29.5512 μM | SANGER | |||
| TE-6 | Growth inhibition assay | IC50 = 29.723 μM | SANGER | |||
| EHEB | Growth inhibition assay | IC50 = 30.3605 μM | SANGER | |||
| SNU-C2B | Growth inhibition assay | IC50 = 30.4898 μM | SANGER | |||
| YAPC | Growth inhibition assay | IC50 = 30.5644 μM | SANGER | |||
| LU-65 | Growth inhibition assay | IC50 = 30.8083 μM | SANGER | |||
| HTC-C3 | Growth inhibition assay | IC50 = 30.8175 μM | SANGER | |||
| HuP-T3 | Growth inhibition assay | IC50 = 30.9157 μM | SANGER | |||
| LB2241-RCC | Growth inhibition assay | IC50 = 31.1032 μM | SANGER | |||
| SK-N-DZ | Growth inhibition assay | IC50 = 31.4228 μM | SANGER | |||
| KYSE-70 | Growth inhibition assay | IC50 = 32.3637 μM | SANGER | |||
| EW-18 | Growth inhibition assay | IC50 = 32.7339 μM | SANGER | |||
| NCI-H1651 | Growth inhibition assay | IC50 = 32.7543 μM | SANGER | |||
| LS-1034 | Growth inhibition assay | IC50 = 33.1173 μM | SANGER | |||
| RXF393 | Growth inhibition assay | IC50 = 33.7866 μM | SANGER | |||
| OMC-1 | Growth inhibition assay | IC50 = 36.8562 μM | SANGER | |||
| OE19 | Growth inhibition assay | IC50 = 36.9759 μM | SANGER | |||
| MHH-CALL-2 | Growth inhibition assay | IC50 = 37.3808 μM | SANGER | |||
| BB49-HNC | Growth inhibition assay | IC50 = 37.3849 μM | SANGER | |||
| A498 | Growth inhibition assay | IC50 = 37.4282 μM | SANGER | |||
| NCI-H1581 | Growth inhibition assay | IC50 = 37.647 μM | SANGER | |||
| LB996-RCC | Growth inhibition assay | IC50 = 38.6567 μM | SANGER | |||
| SKG-IIIa | Growth inhibition assay | IC50 = 38.976 μM | SANGER | |||
| SBC-1 | Growth inhibition assay | IC50 = 39.1276 μM | SANGER | |||
| TE-441-T | Growth inhibition assay | IC50 = 39.1447 μM | SANGER | |||
| KINGS-1 | Growth inhibition assay | IC50 = 39.2733 μM | SANGER | |||
| NCI-H28 | Growth inhibition assay | IC50 = 39.4002 μM | SANGER | |||
| NCI-H1618 | Growth inhibition assay | IC50 = 40.1041 μM | SANGER | |||
| MFE-280 | Growth inhibition assay | IC50 = 40.5005 μM | SANGER | |||
| EB-3 | Growth inhibition assay | IC50 = 40.6243 μM | SANGER | |||
| IM-9 | Growth inhibition assay | IC50 = 41.6341 μM | SANGER | |||
| DV-90 | Growth inhibition assay | IC50 = 41.9741 μM | SANGER | |||
| NCI-H1792 | Growth inhibition assay | IC50 = 42.6858 μM | SANGER | |||
| SNU-387 | Growth inhibition assay | IC50 = 43.2181 μM | SANGER | |||
| HCC1395 | Growth inhibition assay | IC50 = 44.7953 μM | SANGER | |||
| TGW | Growth inhibition assay | IC50 = 46.3289 μM | SANGER | |||
| KY821 | Growth inhibition assay | IC50 = 47.0932 μM | SANGER | |||
| ECC4 | Growth inhibition assay | IC50 = 48.0182 μM | SANGER | |||
| KARPAS-45 | Growth inhibition assay | IC50 = 48.2359 μM | SANGER | |||
| LB2518-MEL | Growth inhibition assay | IC50 = 48.5056 μM | SANGER | |||
| COR-L88 | Growth inhibition assay | IC50 = 48.735 μM | SANGER | |||
| COLO-741 | Growth inhibition assay | IC50 = 48.8966 μM | SANGER | |||
| HCE-T | Growth inhibition assay | IC50 = 49.301 μM | SANGER | |||
| NCI-H1755 | Growth inhibition assay | IC50 = 49.3468 μM | SANGER | |||
| Clicca per visualizzare più dati sperimentali sulle linee cellulari | ||||||
Informazioni chimiche, conservazione e stabilità
| Peso molecolare | 588.56 | Formula | C29H32O13 |
Conservazione (Dalla data di ricezione) | |
|---|---|---|---|---|---|
| N. CAS | 33419-42-0 | Scarica SDF | Conservazione delle soluzioni stock |
|
|
| Sinonimi | VP-16213,VP-16 | Smiles | CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O | ||
Solubilità
|
In vitro |
DMSO
: 100 mg/mL
(169.9 mM)
Water : Insoluble Ethanol : Insoluble |
Calcolatore di Molarità
Calcolatore di Diluizione
Calcolatore del Peso Molecolare
|
In vivo |
|||||
Calcolatore di formulazione in vivo (Soluzione chiara)
Passo 1: Inserire le informazioni di seguito (Consigliato: Un animale aggiuntivo per tenere conto della perdita durante lesperimento)
mg/kg
g
μL
Passo 2: Inserire la formulazione in vivo (Questo è solo il calcolatore, non la formulazione. Contattateci prima se non cè una formulazione in vivo nella sezione Solubilità.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
Risultati del calcolo:
Concentrazione di lavoro: mg/ml;
Metodo per preparare il liquido master di DMSO: mg farmaco predissolto in μL DMSO ( Concentrazione del liquido master mg/mL, Vi preghiamo di contattarci prima se la concentrazione supera la solubilità del DMSO del lotto del farmaco. )
Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungereμL PEG300, mescolare e chiarire, quindi aggiungereμL Tween 80, mescolare e chiarire, quindi aggiungere μL ddH2O, mescolare e chiarire.
Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungere μL Olio di mais, mescolare e chiarire.
Nota: 1. Si prega di assicurarsi che il liquido sia limpido prima di aggiungere il solvente successivo.
2. Assicurarsi di aggiungere il/i solvente/i in ordine. È necessario assicurarsi che la soluzione ottenuta, nellaggiunta precedente, sia una soluzione limpida prima di procedere allaggiunta del solvente successivo. Metodi fisici come il vortex, gli ultrasuoni o il bagno dacqua calda possono essere utilizzati per facilitare la dissoluzione.
Meccanismo dazione
| Targets/IC50/Ki |
Topo II
(Cell-free assay) |
|---|---|
| In vitro |
Etoposide inibisce la sintesi del DNA formando un complesso con topoisomerase II e DNA, che induce rotture nel DNA a doppio filamento e previene la riparazione mediante il legame della topoisomerase II. Le rotture accumulate nel DNA impediscono l'ingresso nella fase mitotica della divisione cellulare e portano alla morte cellulare. Questo composto agisce principalmente nelle fasi G2 e S del ciclo cellulare. Inibisce la crescita della linea cellulare di angiosarcoma murino (ISOS-1) in un periodo di 5 giorni con IC50 di 0,25 μg/mL. La crescita cellulare delle normali cellule endoteliali microvascolari murine (mECs) è meno sensibile a questa sostanza chimica con IC50 di 10 μg/mL). Questo agente trattato per 6 ore inibisce le colonie della variante tetraploide della linea linfoblastica leucemica umana CCRF-CEM con IC50 di 0,6 μM. Trattato per 2 ore inibisce la crescita delle linee cellulari di cancro del pancreas umano Y1, Y3, Y5, Y19, YM. YS e YT con IC50 di 300 μg/mL, 300 μg/mL, 300 μg/mL, 91 μg/mL, 0,68 μg/mL, 300 μg/mL, 300 μg/mL e 260 μg/mL, rispettivamente. Questo composto esposto per 1 ora inibisce la crescita delle linee cellulari di glioma umano CL5, G142, G152, G111 e G5 con IC50 di 8, 9, 9,8, 10 e 15,8 μg/mL rispettivamente per 12 giorni. Nelle stesse condizioni, il valore IC90 si raggiunge nelle linee cellulari CL5, G152, G142 e G111 a 26, 27, 32 e 33 μg/mL. La sua inibizione della topoisomerase II è omogenea per ogni cellula. I tassi di inibizione medi sono 15%, 21,8%, 31,8%, 41,5% e 49,5% per 1, 2, 4, 8 e 16 μg di questo agente, rispettivamente. |
| Saggio chinasico |
saggio di attività della Topoisomerase II
|
|
Si preparano estratti nucleari e si isolano i nuclei. L'attività della topoisomerase II viene calcolata dalla percentuale di decatenazione ottenuta. Viene utilizzato come substrato DNA kinoplastico tritiato (KDNA 0,22 μg). Etoposide e topoisomerase II vengono incubati per 30 min a 37 ℃ e l'attività viene interrotta con 1% di sodio dodecil solfato (SDS) e proteinasi K (100 μg/mL). Si ottengono le percentuali di decatenazione e inibizione della topoisomerase II da parte di questo composto.
|
|
| In vivo |
L'Etoposide somministrato come agente singolo si è dimostrato inefficace nella crescita di molti xenotrapianti, come l'epatoblastoma eterotrapiantato NMHB1 e NMHB 2, lo xenotrapianto di neuroblastoma umano, e lo xenotrapianto di cancro gastrointestinale umano, mentre la dose di 10 mg/kg i.p. di questo composto inibisce i tumori di cellule di angiosarcoma murino ISOS-1 nel 36% dei controlli. Questo agente chimico induce l'immunità tumorale nel cancro del polmone di Lewis. Una singola somministrazione di 50 mg/kg di questo agente i.p. induce una sopravvivenza del 60% dei topi C57B1/6 iniettati con cellule di cancro del polmone di Lewis (3LL) per oltre 60 giorni. Circa il 40% di questi topi sopravvissuti rifiuta una successiva sfida con 3LL, mentre nessuno dei topi di controllo sopravvive oltre 30 giorni. Le cellule 3LL che sono sopravvissute a una concentrazione letale del 90% di questo composto in vitro uccidono il 75% dei topi riceventi, ma il 60% dei topi sopravvissuti rifiuta la sfida con 3LL. Gli splenociti raccolti dai topi che rifiutano il tumore proteggono i topi ingenui iniettati con 3LL. |
Riferimenti |
|
Applicazioni
| Metodi | Biomarcatori | Immagini | PMID |
|---|---|---|---|
| Western blot | p53 / p-p53 / Acetyl-p53 / TF-IIB p53 / p21 / c-Myc / PARP |
|
23800173 |
| Immunofluorescence | COX IV γH2AX / pATM MDC1 pDNA-PKcs p53 YAP |
|
29221178 |
| Growth inhibition assay | Cell viability |
|
22615609 |
Informazioni sullo studio clinico
(dati da https://clinicaltrials.gov, aggiornato il 2024-05-22)
| Numero NCT | Reclutamento | Condizioni | Sponsor/Collaboratori | Data di inizio | Fasi |
|---|---|---|---|---|---|
| NCT06393816 | Not yet recruiting | Large Cell Neuroendocrine Carcinoma of the Lung |
Centre Leon Berard|Groupe Français de Pneumo-Cancérologie |
May 2024 | Phase 2 |
| NCT06406465 | Not yet recruiting | Carcinoma Neuroendocrine|Tumor Neuroendocrine|Tumors Neuroendocrine|Neuroendocrine; Carcinoma|Small Cell; Receptors |
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
May 15 2024 | Phase 2 |
| NCT06086288 | Not yet recruiting | Merkel Cell Carcinoma |
Fondazione IRCCS Istituto Nazionale dei Tumori Milano |
November 2023 | Phase 2 |
Supporto tecnico
Istruzioni per la manipolazione
Tel: +1-832-582-8158 Ext:3
Per qualsiasi altra domanda, si prega di lasciare un messaggio.
Domande Frequenti
Domanda 1:
Regarding the S1225, do you have any data of the inhibition specificity of this product? It will inhibit other enzymes other than TOP2A?
Risposta:
According to the available published data, its inhibition is specific to TOP2A. But there're also two papers showing that it could inhibit the p34cdc2 Kinase Activity: 1. http://cancerres.aacrjournals.org/content/52/7/1817.short ; 2. http://cancerres.aacrjournals.org/content/50/12/3761.short.
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