réservé à la recherche
PF-562271 (VS-6062) inhibiteur de FAK/Pyk2
N° Cat.S2890
Structure chimique
Poids moléculaire: 507.49
Aller à
Contrôle qualité
Lot :
Pureté :
99.95%
99.95
| Cibles apparentées | EGFR VEGFR JAK PDGFR FGFR Src HIF FLT FLT3 HER2 |
|---|---|
| Autre FAK Inhibiteurs | Defactinib (VS-6063) PF-573228 VS-4718 (PND-1186) PF-562271 HCl PF-562271 Besylate TAE226 (NVP-TAE226) GSK2256098 PF-431396 Y15 Solanesol (Nonaisoprenol) |
Culture cellulaire, traitement et concentration de travail
| Lignées cellulaires | Type dessai | Concentration | Temps dincubation | Formulation | Description de lactivité | PMID |
|---|---|---|---|---|---|---|
| IST-MES1 | Growth Inhibition Assay | IC50=49.8944 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=49.6731 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=49.0492 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=48.8954 μM | SANGER | |||
| RT4 | Growth Inhibition Assay | IC50=48.8377 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=48.1401 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=47.6434 μM | SANGER | |||
| LC-1F | Growth Inhibition Assay | IC50=47.6105 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=47.3123 μM | SANGER | |||
| BL-70 | Growth Inhibition Assay | IC50=46.7737 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=46.5917 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=46.2789 μM | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | IC50=46.1869 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=46.0592 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=45.1117 μM | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=44.9136 μM | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | IC50=44.7414 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=43.4288 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=42.8008 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=42.2942 μM | SANGER | |||
| PF-382 | Growth Inhibition Assay | IC50=40.7487 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=40.595 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=39.9977 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=39.6282 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=39.5091 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=39.0509 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=39.0218 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=38.0239 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=37.7647 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=37.5358 μM | SANGER | |||
| KARPAS-422 | Growth Inhibition Assay | IC50=37.4431 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=37.1903 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=37.0154 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=36.8536 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=36.7298 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=36.6566 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=36.4924 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=35.8264 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=35.7718 μM | SANGER | |||
| EFE-184 | Growth Inhibition Assay | IC50=35.6829 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=35.4141 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=35.4024 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=35.2185 μM | SANGER | |||
| NCI-H1417 | Growth Inhibition Assay | IC50=33.9585 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=33.6746 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=33.654 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=33.5655 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=33.3679 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=33.2235 μM | SANGER | |||
| EHEB | Growth Inhibition Assay | IC50=33.0494 μM | SANGER | |||
| LU-165 | Growth Inhibition Assay | IC50=33.008 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=32.6163 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=32.3825 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=32.1386 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=31.7306 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=31.6283 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=31.5625 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=31.4992 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=31.3008 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=31.112 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=31.0621 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=31.0424 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=30.8953 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=30.6794 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=30.2477 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=30.1475 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=30.0053 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=29.732 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=29.6046 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=29.5466 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=29.2167 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=29.012 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=28.9906 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=28.8708 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=28.6579 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=28.3171 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=28.2592 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=28.2459 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=28.1925 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=28.0495 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=27.6975 μM | SANGER | |||
| SNU-C1 | Growth Inhibition Assay | IC50=27.6491 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=27.5548 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=27.1973 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=27.1754 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=27.0271 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=26.9086 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=26.5553 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=26.5406 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=26.5305 μM | SANGER | |||
| Daudi | Growth Inhibition Assay | IC50=26.5158 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=26.5152 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=25.9901 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=25.7501 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=25.7459 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=25.4743 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=25.357 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=25.2337 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=24.9237 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=24.7624 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=24.5883 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=24.5217 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=24.4977 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=24.1844 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=23.7461 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=23.6623 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=23.6093 μM | SANGER | |||
| MC-CAR | Growth Inhibition Assay | IC50=23.5183 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=23.3546 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=23.2511 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=23.0646 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=22.8836 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=22.8177 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=22.6746 μM | SANGER | |||
| IMR-5 | Growth Inhibition Assay | IC50=22.287 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=22.1677 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=22.0367 μM | SANGER | |||
| NCI-H1694 | Growth Inhibition Assay | IC50=21.9863 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=21.9688 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=21.8631 μM | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | IC50=21.8596 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=21.7687 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=21.6837 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=21.5827 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=21.5094 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=21.4971 μM | SANGER | |||
| NCI-H64 | Growth Inhibition Assay | IC50=21.4756 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=21.3893 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=21.3288 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=21.3202 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=21.3188 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=20.5814 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=20.4613 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=20.3953 μM | SANGER | |||
| Raji | Growth Inhibition Assay | IC50=20.2568 μM | SANGER | |||
| EW-7 | Growth Inhibition Assay | IC50=20.1628 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=20.1577 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=19.6268 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=19.5944 μM | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | IC50=19.5725 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=19.2219 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=19.2155 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=19.2029 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=19.1796 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=19.1754 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=18.8918 μM | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | IC50=18.8585 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=18.8299 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=18.2062 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=18.0669 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=17.9958 μM | SANGER | |||
| CESS | Growth Inhibition Assay | IC50=17.9326 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=17.825 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=17.7936 μM | SANGER | |||
| EB2 | Growth Inhibition Assay | IC50=17.7426 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=16.9219 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=16.6138 μM | SANGER | |||
| THP-1 | Growth Inhibition Assay | IC50=16.4665 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=16.3742 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=16.2218 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=15.9497 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=15.8926 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=15.6941 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=15.4163 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=15.2868 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=15.0862 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=15.0165 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=15.0158 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=14.9384 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=14.5577 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=14.4336 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=14.2599 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=14.2407 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=14.236 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=14.1906 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=13.7453 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=13.5503 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=13.5503 μM | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | IC50=13.5031 μM | SANGER | |||
| CCF-STTG1 | Growth Inhibition Assay | IC50=13.4039 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=13.1469 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=13.013 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=12.9487 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=12.9456 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=12.9437 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=12.93 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=12.6952 μM | SANGER | |||
| NCI-H2141 | Growth Inhibition Assay | IC50=12.658 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=12.6174 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=12.612 μM | SANGER | |||
| SK-MM-2 | Growth Inhibition Assay | IC50=12.4087 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=12.3851 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=12.3421 μM | SANGER | |||
| REH | Growth Inhibition Assay | IC50=12.1573 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=12.1447 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=12.1369 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=12.1207 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=12.019 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=12.0139 μM | SANGER | |||
| L-540 | Growth Inhibition Assay | IC50=11.899 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=11.8519 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=11.7619 μM | SANGER | |||
| BL-41 | Growth Inhibition Assay | IC50=11.7173 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=11.6181 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=11.6072 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=11.576 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=11.3237 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=11.2889 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=11.2119 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=11.1389 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=11.1209 μM | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=11.0892 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=10.9455 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=10.9373 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=10.7068 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=10.6374 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=10.6181 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=10.5105 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=10.4608 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=10.4285 μM | SANGER | |||
| YT | Growth Inhibition Assay | IC50=10.4001 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=10.3227 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=10.2943 μM | SANGER | |||
| SJRH30 | Growth Inhibition Assay | IC50=10.1844 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=10.1776 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=10.1392 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=10.0093 μM | SANGER | |||
| U-698-M | Growth Inhibition Assay | IC50=9.997 μM | SANGER | |||
| NCI-H716 | Growth Inhibition Assay | IC50=9.93322 μM | SANGER | |||
| CHP-126 | Growth Inhibition Assay | IC50=9.9329 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=9.84828 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=9.77984 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=9.76806 μM | SANGER | |||
| SK-CO-1 | Growth Inhibition Assay | IC50=9.76235 μM | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | IC50=9.75535 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=9.43407 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=9.39652 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=9.37297 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=9.29007 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=9.27309 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=9.24143 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=9.21098 μM | SANGER | |||
| NCI-H719 | Growth Inhibition Assay | IC50=9.18391 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=9.125 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=9.12373 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=9.06012 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=9.02542 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=8.96063 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=8.95566 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=8.80439 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=8.79772 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=8.76561 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=8.73107 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=8.70296 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=8.66694 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=8.61529 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=8.48595 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=8.41853 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=8.3692 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=8.35723 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=8.34124 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=8.29308 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=8.29185 μM | SANGER | |||
| IPC-298 | Growth Inhibition Assay | IC50=8.27709 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=8.24598 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=8.23713 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=8.06521 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=7.94553 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=7.90685 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=7.8356 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=7.78555 μM | SANGER | |||
| ECC12 | Growth Inhibition Assay | IC50=7.72901 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=7.69416 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=7.67975 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=7.54689 μM | SANGER | |||
| IST-SL2 | Growth Inhibition Assay | IC50=7.52272 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=7.48794 μM | SANGER | |||
| HCC1143 | Growth Inhibition Assay | IC50=7.37898 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=7.24024 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=7.21273 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=7.18038 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=7.16906 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=7.09791 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=7.0349 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=7.02678 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=6.96315 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=6.95192 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=6.94715 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=6.94348 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=6.93546 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=6.90901 μM | SANGER | |||
| C-4-II | Growth Inhibition Assay | IC50=6.83117 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=6.76072 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=6.75127 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=6.72377 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=6.65435 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=6.55625 μM | SANGER | |||
| NCI-H838 | Growth Inhibition Assay | IC50=6.51703 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=6.4784 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=6.4498 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=6.42493 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=6.4036 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=6.37638 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=6.27868 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=6.17396 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=6.1516 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=6.14689 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=6.13072 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=6.12497 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=6.03787 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=6.02188 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=5.90148 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=5.88206 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=5.85891 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=5.79581 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=5.74005 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=5.62042 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=5.61788 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=5.60421 μM | SANGER | |||
| TE-15 | Growth Inhibition Assay | IC50=5.57779 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=5.56896 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=5.56887 μM | SANGER | |||
| SR | Growth Inhibition Assay | IC50=5.53645 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=5.44569 μM | SANGER | |||
| GDM-1 | Growth Inhibition Assay | IC50=5.41781 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=5.41465 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=5.41409 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=5.39689 μM | SANGER | |||
| LC4-1 | Growth Inhibition Assay | IC50=5.39303 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=5.37077 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=5.30538 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=5.30438 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=5.29771 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=5.29218 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=5.25371 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=5.09139 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=5.02834 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=4.94919 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=4.79293 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=4.76849 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=4.7466 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=4.72633 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=4.70665 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=4.68228 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=4.6728 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=4.63145 μM | SANGER | |||
| Calu-1 | Growth Inhibition Assay | IC50=4.58707 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=4.55996 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=4.55516 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=4.49701 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=4.48822 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=4.48532 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=4.47753 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=4.44299 μM | SANGER | |||
| BC-3 | Growth Inhibition Assay | IC50=4.43477 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=4.42685 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=4.42459 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=4.38567 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=4.35552 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=4.33723 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=4.31016 μM | SANGER | |||
| DV-90 | Growth Inhibition Assay | IC50=4.29397 μM | SANGER | |||
| NCI-H1734 | Growth Inhibition Assay | IC50=4.26695 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=4.22887 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=4.18961 μM | SANGER | |||
| CA46 | Growth Inhibition Assay | IC50=4.16104 μM | SANGER | |||
| SIMA | Growth Inhibition Assay | IC50=4.144 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=4.12975 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=4.10777 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=4.09549 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=4.09429 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=4.0906 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=4.08674 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=4.07861 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=4.0773 μM | SANGER | |||
| NB1 | Growth Inhibition Assay | IC50=4.06644 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=4.0237 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=3.95782 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=3.94843 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=3.90956 μM | SANGER | |||
| TE-441-T | Growth Inhibition Assay | IC50=3.8293 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=3.81676 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=3.81657 μM | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | IC50=3.7832 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=3.7751 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=3.76958 μM | SANGER | |||
| RL95-2 | Growth Inhibition Assay | IC50=3.71864 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=3.67882 μM | SANGER | |||
| NCI-H2081 | Growth Inhibition Assay | IC50=3.65288 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=3.60311 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=3.57612 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=3.5735 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=3.50711 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=3.49204 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=3.48715 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=3.48674 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=3.47569 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=3.40544 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=3.36352 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=3.29808 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=3.29465 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=3.25377 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=3.2114 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=3.20137 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=3.15798 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=3.13961 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=3.10341 μM | SANGER | |||
| NCI-H1963 | Growth Inhibition Assay | IC50=3.08825 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=3.05784 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=3.0532 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=2.98334 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=2.98029 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=2.92439 μM | SANGER | |||
| OPM-2 | Growth Inhibition Assay | IC50=2.89978 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=2.86204 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=2.83987 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=2.83827 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=2.81447 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=2.78389 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=2.75252 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=2.71646 μM | SANGER | |||
| TUR | Growth Inhibition Assay | IC50=2.65369 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=2.63879 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=2.60712 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=2.58997 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=2.58273 μM | SANGER | |||
| NCCIT | Growth Inhibition Assay | IC50=2.5724 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=2.56517 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=2.5282 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=2.51888 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=2.49572 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=2.49118 μM | SANGER | |||
| MFE-296 | Growth Inhibition Assay | IC50=2.47792 μM | SANGER | |||
| CMK | Growth Inhibition Assay | IC50=2.41795 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=2.41628 μM | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=2.41248 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=2.35436 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=2.34745 μM | SANGER | |||
| KASUMI-1 | Growth Inhibition Assay | IC50=2.3288 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=2.32507 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=2.30673 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=2.28874 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=2.2846 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=2.26966 μM | SANGER | |||
| LOUCY | Growth Inhibition Assay | IC50=2.26128 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=2.25196 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=2.14759 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=2.12818 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=2.09539 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=2.04839 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=2.03983 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=2.00988 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=2.00151 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=1.97993 μM | SANGER | |||
| MDA-MB-468 | Growth Inhibition Assay | IC50=1.91272 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=1.90315 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=1.85614 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=1.8049 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=1.79568 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=1.74031 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=1.72891 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=1.66802 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=1.65663 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=1.63522 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=1.63466 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=1.62628 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=1.62312 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=1.61679 μM | SANGER | |||
| BC-1 | Growth Inhibition Assay | IC50=1.61664 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=1.55818 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=1.5395 μM | SANGER | |||
| ST486 | Growth Inhibition Assay | IC50=1.53278 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=1.52124 μM | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | IC50=1.48387 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=1.44886 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=1.44647 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=1.35236 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=1.35222 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=1.31909 μM | SANGER | |||
| MES-SA | Growth Inhibition Assay | IC50=1.30682 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=1.28766 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=1.27506 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=1.21867 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=1.12938 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=1.10776 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=1.09904 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=1.04714 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=1.01584 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=1.01288 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.9846 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=0.83154 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.81038 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=0.80637 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.75176 μM | SANGER | |||
| COLO-205 | Growth Inhibition Assay | IC50=0.48658 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.38557 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.3282 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.2766 μM | SANGER | |||
| sf9 | Function assay | Reversible/competitive inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infected sf9 cells using p(Glu/Tyr) as substrate in presence of ATP, IC50 = 0.0015 μM. | 27876318 | |||
| sf21 | Function assay | Inhibition of full length recombinant human N-terminal His6-tagged PYK2 expressed in baculovirus infected sf21 cells, IC50 = 0.013 μM. | 27876318 | |||
| TC32 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 29435139 | |||
| DAOY | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 29435139 | |||
| SJ-GBM2 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 29435139 | |||
| A673 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 29435139 | |||
| SK-N-MC | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 29435139 | |||
| BT-37 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 29435139 | |||
| NB-EBc1 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 29435139 | |||
| Saos-2 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 29435139 | |||
| SK-N-SH | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 29435139 | |||
| NB1643 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 29435139 | |||
| BT-12 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 29435139 | |||
| OHS-50 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 29435139 | |||
| RD | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 29435139 | |||
| MG 63 (6-TG R) | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 29435139 | |||
| wild type fibroblast cells | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 29435139 | |||
| Rh41 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 29435139 | |||
| A673 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 29435139 | |||
| BT-12 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 29435139 | |||
| LAN-5 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 29435139 | |||
| DAOY | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 29435139 | |||
| BT-37 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 29435139 | |||
| U-2 OS | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 29435139 | |||
| Rh41 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 29435139 | |||
| Saos-2 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 29435139 | |||
| OHS-50 | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 29435139 | |||
| SK-N-SH | qHTS assay | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 29435139 | |||
| Cliquez pour voir plus de données expérimentales sur les lignées cellulaires | ||||||
Informations chimiques, stockage et stabilité
| Poids moléculaire | 507.49 | Formule | C21H20F3N7O3S |
Stockage (À partir de la date de réception) | |
|---|---|---|---|---|---|
| N° CAS | 717907-75-0 | Télécharger le SDF | Stockage des solutions mères |
|
|
| Synonymes | PF-00562271 | Smiles | CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C | ||
Solubilité
|
In vitro |
DMSO
: 100 mg/mL
(197.04 mM)
Water : ˂1 mg/mL Ethanol : ˂1 mg/mL |
Calculateur de molarité
Calculateur de dilution
Calculateur de poids moléculaire
|
In vivo |
|||||
Calculateur de formulation in vivo (Solution claire)
Étape 1 : Entrez les informations ci-dessous (Recommandé : Un animal supplémentaire pour tenir compte des pertes pendant lexpérience)
mg/kg
g
μL
Étape 2 : Entrez la formulation in vivo (Ceci nest que le calculateur, pas la formulation. Veuillez nous contacter dabord sil ny a pas de formulation in vivo dans la section Solubilité.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
Résultats du calcul :
Concentration de travail : mg/ml;
Méthode de préparation du liquide maître DMSO : mg médicament prédissous dans μL DMSO ( Concentration du liquide maître mg/mL, Veuillez nous contacter dabord si la concentration dépasse la solubilité du DMSO du lot de médicament. )
Méthode de préparation de la formulation in vivo : Prendre μL DMSO liquide maître, ajouter ensuiteμL PEG300, mélanger et clarifier, ajouter ensuiteμL Tween 80, mélanger et clarifier, ajouter ensuite μL ddH2O, mélanger et clarifier.
Méthode de préparation de la formulation in vivo : Prendre μL DMSO liquide maître, ajouter ensuite μL Huile de maïs, mélanger et clarifier.
Remarque : 1. Assurez-vous que le liquide est clair avant dajouter le solvant suivant.
2. Assurez-vous dajouter le(s) solvant(s) dans lordre. Vous devez vous assurer que la solution obtenue lors de lajout précédent est une solution claire avant de procéder à lajout du solvant suivant. Des méthodes physiques telles que le vortex, les ultrasons ou le bain-marie peuvent être utilisées pour faciliter la dissolution.
Mécanisme daction
| Targets/IC50/Ki |
FAK
(Cell-free assay) 1.5 nM
PYK2
(Cell-free assay) 13 nM
CDK2/CyclinE
(Cell-free assay) 30 nM
CDK3/CyclinE
(Cell-free assay) 47 nM
CDK1/CyclinB
(Cell-free assay) 58 nM
CDK7/CyclinH/MAT1
(Cell-free assay) 97 nM
FLT3
(Cell-free assay) 97 nM
GSK-3α
(Cell-free assay) 101 nM
CDK5/p35
(Cell-free assay) 120 nM
GSK-3β
(Cell-free assay) 133 nM
Aurora A
(Cell-free assay) 145 nM
|
|---|---|
| In vitro |
Le PF-562271 se lie dans la fente de liaison à l'ATP de FAK, formant deux des trois liaisons H "canoniques" entre l'inhibiteur et les atomes de la chaîne principale dans la région de la charnière de la kinase. Ce composé est puissant dans un essai basé sur des cellules inductibles mesurant le phospho-FAK avec un IC50 de 5 nM. Il (3,3 A.M.) entraîne un arrêt en G1 des cellules PC3-M. Ce produit chimique (1 nM) bloque l'angiogenèse des vaisseaux sanguins stimulée par le bFGF, telle que réalisée dans des essais sur membrane chorioallantoïque de poulet. Il bloque puissamment la germination des vaisseaux sanguins sans changements détectables de la fuite vasculaire. Il (250 nM) entraîne une inhibition complète de l'invasion collective des cellules A431 dans les gels de collagène. |
| Kinase Assay |
Essai kinase recombinant
|
|
Le domaine kinase FAK purifié-activé (410-689 aa) est mis à réagir avec 50
A.M. d'ATP et 10
A.G. par puits d'un polymère peptidique aléatoire de Glu et Tyr, p(Glu/Tyr), dans un tampon kinase [50
A.M. HEPES (pH 7,5), 125
A.M. NaCl, et 48
A.M. MgCl2 pendant 15 min. La phosphorylation de p(Glu/Tyr) est contestée avec un composé dilué en série à des concentrations de 1/2-Log en commençant par une concentration maximale de 1
A.M. Chaque concentration est testée en triple. La phosphorylation de p(Glu/Tyr) est détectée avec un anticorps antiphospho-tyrosine général (PY20) suivi d'un anticorps de chèvre anti-souris IgG conjugué à la peroxydase de raifort (HRP). Le substrat HRP est ajouté, et les lectures d'absorbance à 450 nm sont obtenues après l'ajout d'une solution d'arrêt (2 mol/L H2SO4). Les valeurs d'IC50 sont déterminées à l'aide du modèle Hill-Slope.
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| In vivo |
Le PF-562271 (< 33 mg/kg p.o.) inhibe la phosphorylation de FAK dans les tumeurs de manière dose- et temps-dépendante chez des souris porteuses de tumeurs U87MG. Ce composé (50 mg/kg p.o. bid) entraîne 86 % d'inhibition de la croissance tumorale chez des souris xénogreffées BxPc3 et 45 % d'inhibition de la croissance tumorale chez des souris xénogreffées PC3-M. Il (25 mg/kg, bid) entraîne une apoptose 2 fois plus importante dans les tumeurs traitées chez des souris porteuses de xénogreffes pulmonaires H125. Ce produit chimique (33 mg/kg, p.o.) inhibe le mouvement étendu des cellules tumorales pendant 24 heures chez des souris. Il (33 mg/kg, p.o.) entraîne des dynamiques altérées de la E-cadhérine chez des souris, ce qui est corrélé à un mouvement collectif des cellules dépendant de la E-cadhérine réduit. Ce composé (25 mg/kg, p.o. bid) entraîne 62 % d'inhibition de la croissance tumorale dans le modèle murin de xénogreffe par implant local sous-cutané PC3M-luc-C6. Il (5 mg/kg, oral) entraîne des augmentations significatives et similaires de l'ostéocalcine et des paramètres de l'os spongieux et une diminution de la croissance tumorale et des signes de guérison osseuse chez des rats implantés avec des cellules MDA-MB-231 dans le tibia. |
Références |
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Applications
| Méthodes | Biomarqueurs | Images | PMID |
|---|---|---|---|
| Western blot | p-FAK / FAK / p-Talin / Talin p-Src / Src / p-paxillin / Paxillin / ICAM-1 |
|
26530902 |
| Immunofluorescence | p-FAK |
|
26530902 |
| Growth inhibition assay | Cell viability |
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28953264 |
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