Home Apoptosis Bcl-2 Mcl-1-Selettivo Inhibitors

Mcl-1-Selettivo Inhibitors

  • Bcl-2
  • Bcl-B
  • Bcl-w
  • Bcl-xL
  • Mcl-1
  • A1
  • Bax
  • Bfl-1
N. Cat. Nome del prodotto Informazioni Selettivo / Pan IC50 / Ki
S7531 UMI-77 UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. Selective Mcl-1, Ki: 490 nM
S2812 AT101 AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID. Phase 2. Pan Mcl-1, Ki: 0.18 μM
S8061 Sabutoclax Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Pan Mcl-1, IC50: 0.20 μM
S1121 TW-37 TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. Pan Mcl-1, Ki: 0.26 μM
S1001 ABT-263 (Navitoclax) ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM, but binds more weakly to Mcl-1 and A1. Phase 2. Pan Mcl-1, Ki: 550 nM
S2448 Gambogic Acid Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. Pan Mcl-1, IC50: 0.79 μM