Bcl-2 Inibitori (Bcl-2 Inhibitors)

Altro Apoptosis Inibitori

Prodotti selettivi di isoforme

• Inibitori in evidenza
• Inibitori (41)
• Modulatori (5)
• Sostanza chimica (1)
• Attivatori (7)
• Agonisti (5)

N. Cat.	Nome del prodotto	Informazioni	Citazioni di utilizzo del prodotto	Validazioni del prodotto
S8048	ABT-199 (Venetoclax)	Venetoclax (ABT-199, GDC-0199) è un inibitore selettivo di Bcl-2 con Ki <0,01 nM in saggi acellulari, >4800 volte più selettivo rispetto a Bcl-xL e Bcl-w, e nessuna attività verso Mcl-1. Venetoclax è riportato indurre la soppressione della crescita cellulare, l'apoptosi, l'arresto del ciclo cellulare e l'autofagia nelle cellule MDA-MB-231 di cancro al seno triplo negativo. Fase 3.	Br J Haematol, 2026, 208(3):905-915 Cell, 2025, S0092-8674(25)00689-0 Cell, 2025, S0092-8674(25)01233-4
S1001	Navitoclax (ABT-263)	Un potente inibitore di Bcl-xL, Bcl-2 e Bcl-w con Ki di ", "0,5 nM, ", "1 nM e ", "1 nM in saggi acellulari, Navitoclax (ABT-263) si lega più debolmente a Mcl-1 e A1. Fase 2.	Cell, 2025, S0092-8674(25)00689-0 Nat Cancer, 2025, 6(2):259-277 Nat Metab, 2025, 7(12):2474-2488.
S8383	S63845	S63845 è un nuovo inibitore selettivo di MCL-1 con un valore di Kd di 0,19 nM e non ha alcun legame discernibile con gli altri membri di Bcl-2, Bcl-2 o BCL-XL.	Biomolecules, July 21, 2020, 1081 Oncogene, January 31, 2022, 1691-1700 Cancer Research Communications, August 1, 2025, 1396-1408
S1002	ABT-737	ABT-737 è un inibitore mimetico di BH3 di Bcl-xL, Bcl-2 e Bcl-w con EC50 di 78.7 nM, 30.3 nM e 197.8 nM in saggi senza cellule, rispettivamente; nessuna inibizione osservata contro Mcl-1, Bcl-B o Bfl-1. ABT-737 induce l'Apoptosis della via mitocondriale e la Mitophagy. Fase 2.	Br J Haematol, 2026, 208(3):905-915 Signal Transduct Target Ther, 2025, 10(1):161 J Hepatol, 2025, S0168-8278(24)02830-7
S7747	Ro-3306	RO-3306 è un inibitore di CDK1 ATP-competitivo e selettivo con un Ki di 20 nM, >15 volte la selettività contro un pannello diversificato di chinasi umane. RO-3306 potenzia l'attivazione di Bax mediata da p53 e l'apoptosi mitocondriale.	Cancer Research, May 1, 2018, 2171-2178 Journal of Cell Science, February 13, 2024, jcs261364 Cancer Cell International, December 19, 2024, 409
S1057	Obatoclax Mesylate (GX15-070)	Obatoclax Mesylate (GX15-070) è un antagonista di Bcl-2 con Ki di 0,22 μM in un saggio senza cellule, in grado di aiutare a superare la resistenza all'apoptosi mediata da MCL-1.	Nat Commun, 2025, 16(1):2416 J Transl Med, 2025, 23(1):1262 bioRxiv, 2024, 10.1101/2023.01.18.524628
S7801	A-1331852	A-1331852 è un potente e selettivo inibitore di BCL-XL con un valore di Ki inferiore a 0,01 nM per BCL-XL e 6 nM, 4 nM, 142 nM per Bcl-2, Bcl-W, MCL-1 rispettivamente. Può essere utile nel trattamento del cancro, delle malattie immunitarie e autoimmuni.	Cell, 2025, S0092-8674(25)00689-0 Mol Cancer, 2025, 24(1):154 Haematologica, 2025, 110(1):78-91
S7790	A-1210477	A-1210477 è un potente e selettivo inibitore di MCL-1 con Ki e IC50 rispettivamente di 0,454 nM e 26,2 nM, con una selettività >100 volte superiore rispetto ad altri membri della famiglia Bcl-2.	Front Pharmacol, 2025, 16:1530270 Cell Rep, 2023, 42(10):113176 Int J Mol Sci, 2023, 24(13)11149
S1121	TW-37	TW-37 è un nuovo inibitore non peptidico della Bcl-2, Bcl-xL e Mcl-1 ricombinante con Ki di 0,29 μM, 1,11 μM e 0,26 μM in saggi senza cellule, rispettivamente.	Signal Transduct Target Ther, 2025, 10(1):161 bioRxiv, 2024, 10.1101/2023.01.18.524628 Cells, 2023, 12(18)2247
S7800	A-1155463 Dihydrochloride	A-1155463 Dihydrochloride, un inibitore di BCL-XL altamente potente e selettivo, mostra un'affinità di legame picomolare a BCL-XL e un legame >1000 volte più debole a BCL-2 e alle proteine correlate BCL-W (Ki=19 nM) e MCL-1 (Ki>440 nM).	Cells, July 2020, 1593 Cell Reports Methods, July 18, 2022, 100256 eLife, December 18, 2018, e40167
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Bcl-2 (B-cell lymphoma 2) is encoded by the Bcl-2 gene and is the first identified member of a large family of apoptosis regulatory proteins (Bcl-2 family) that derives its name from the B-cell lymphoma 2, as it is the second member of a variety of proteins initially described in the t(14;18) chromosomal translocation in human follicular B-cell lymphomas. Bcl-2 contains four Bcl-2 homology domains (BH1-BH4) that mediate the formation of homodimer and heterodimer with relative proteins such as Bax, Bad, Bak and Bcl-xL, and a trans-membrane (TM) domain that mediates insertion into the outer membrane of the mitochondria and the endoplasmic reticulum. Bcl-2 proteins are generally integrated within the outer mitochondrial membrane (OMM), and may also be in the cytosol or ER membrane. The Bcl-2 and other antiapoptotic members of the Bcl-2 family preserve the outer mitochondrial membrane (OMM) integrity, thus inhibiting the mitochondrial signaling pathway of apoptosis, by complex interactions with the proapoptotic Bcl-2 proteins such as Bax, Bak, Bim, Puma and tBid. ^[1][2]

Bcl-2 suppresses apoptosis in response to a broad range of stress stimuli, including those frequently encountered during tumor development, such as oncogene activation, DNA damage, hypoxia (oxygen deprivation), loss of appropriate growth signals and anoikis (loss of cell attachment). In healthy cells, Bax and Bak are kept in check by the pro-survival Bcl-2 family members and the binding of BH3-only proteins unleashes Bax/Bak. Bcl-2 is also critical for the survival of renal epithelial stem cells during embryogenesis, melanocyte progenitors and mature B and T lymphocytes. Bcl-2 over-expression accelerates Eu-myc-induced lymphomagenesis, but loss of endogenous Bcl-2 does not prevent or delay Eu-myc-induced B lymphoma development. Bcl-2 proteins also constitutively binds to Beclin-1, and its dissociation through post-translational modification of Beclin-1 and/or Bcl-2 proteins such as phosphorylation by JNK1, or direct competition for the Bcl-2 BC groove by another BH3-only protein such as Bad, may be sufficient to induce autophagy, leading to the suggestion that autophagy and apoptosis are mechanistically linked. Single-site phosphorylation at Serine 70 (S70) is required for the antiapoptotic function of Bcl-2, and multisite phosphorylation at Threonine 69, S70, and S87 has been reported to inactivate Bcl-2. Phosphorylation of Bcl-2 has been shown to enhance activity to allow response to extracellular growth-factor-mediated signals. ^[1][2][3]

In addition, Bcl-2 is over-expressed in human follicular centre B-cell lymphoma; high levels of Bcl-2 are also detected in significant numbers of chronic lymphocytic leukaemia (CLL), DLBCL and mantle cell lymphoma, as well as in certain solid tumours(brain, breast and lung). The upregulation of Bcl-2 in CLL and other cancers has been attributed to the hypo-methylation of the Bcl-2 promoter or, possibly more importantly due to hemizygous or homozygous loss of the micro RNAs (miRs) 15a and 16-1 that negatively regulate Bcl-2. The dysregulated Bcl-2 proteins in cancer can lead to increased survival of abnormal cells, which are thought to be involved in resistance to conventional cancer treatment. Mice that constitutively express both Myc and Bcl-2 transgenes develop lymphoblastic leukaemia with high incidence, while shut-down of the inducible Bcl-2 transgene in lymphoma-burdened bi-transgenic mice results in tumor regression and significantly prolonged animal survival in many cases, indicating that inactivation of Bcl-2 constitutes a promising new approach to cancer therapy. Small molecule mimetics of BH3-only proteins that can directly target pro-survival Bcl-2 family members are being developed as a novel therapeutic approach. ABT-737 and the closely related orally bioavailable ABT-263, belong to the BH3 mimetic small molecule inhibitors, targeting Bcl-2 and Bcl-2-related proteins such as Bcl-xL and Bcl-w, therefore promoting tumor regression in murine xeno-transplanation models of certain human lymphomas or small cell lung carcinomas and in primary patient-derived follicular lymphoma cells. ^[1][4]