Home Apoptosis Bcl-2 Bcl-B Inhibitors

Bcl-B Inhibitors

  • Bcl-2
  • Bcl-B
  • Bcl-w
  • Bcl-xL
  • Mcl-1
  • A1
  • Bax
  • Bfl-1
N. Cat. Nome del prodotto Informazioni Selettivo / Pan IC50 / Ki
S2448 Gambogic Acid Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. Pan Bcl-B, IC50: 0.66 μM
S1002 ABT-737 ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2. Pan Bcl-B, EC50: 1.82 μM