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PDE3-Selettivo Inhibitors

  • PDE1
  • PDE2
  • PDE3
  • PDE4
  • PDE5
  • PDE6
  • PDE10A
N. Cat. Nome del prodotto Informazioni Selettivo / Pan IC50 / Ki
S1294 Cilostazol Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. Selective PDE3, IC50: 0.2 μM
S1550 Pimobendan Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. Selective PDE3, IC50: 0.32 μM
S2484 Milrinone Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility. Pan PDE3, IC50: 2.1 μM
S2320 Luteolin Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2. Pan PDE3, Ki: 13.9 μM
S4090 Fenspiride HCl Fenspiride is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi. Pan PDE3, pIC50: 3.44