Home TGF-beta/Smad -Stem Cells & Wnt TGF-beta/Smad ALK4 Inhibitors

ALK4 Inhibitors

N. Cat.	Nome del prodotto	Informazioni	Selettivo / Pan	IC50 / Ki
S7530	EW-7197	EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1.	Pan	ALK4, IC50: 13 nM
S2186	SB505124	SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.	Pan	ALK4, IC50: 129 nM
S7359	K02288	K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.	Pan	ALK4, IC50: 302 nM; ALK4, IC50: 302 nM
S7147	LDN-212854	LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.	Pan	ALK4, IC50: 2133 nM
S1067	SB431542	SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.	Pan