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KU-55933 Inibitore di ATM

Name: KU-55933
Brand: Selleck Chemicals
SKU: S1092
Rating: 5 (403 reviews)

N. Cat.: S1092

KU-55933 è un potente e specifico inibitore di ATM con IC50/K_i di 12,9 nM/2,2 nM in saggi acellulari, ed è altamente selettivo per ATM rispetto a DNA-PK, PI3K/PI4K, ATR e mTOR. KU‑55933 (Inibitore della chinasi ATM) inibisce l'attivazione della chinasi ULK1 che inizia l'autofagia e provoca una significativa diminuzione dell'autofagia.

KU-55933 ATM/ATR Inibitore Chemical Structure

Struttura chimica

Peso molecolare: 395.49

Vai a

Controllo Qualità (Quality Control)

Lotto: Purezza: 99.95%

99.95

Target correlati	HDAC PARP DNA-PK WRN DNA/RNA Synthesis Topoisomerase PPAR Sirtuin Casein Kinase eIF
Altro ATM/ATR Inibitori	Ceralasertib (AZD6738) AZD1390 Berzosertib (VE-822) Lartesertib (M4076) Camonsertib (RP-3500) KU-60019 VE-821 AZ20 AZD0156 Mirin

Coltura cellulare, trattamento e concentrazione di lavoro
(Cell Culture, Treatment & Working Concentration)

Linee cellulari	Tipo di saggio	Concentrazione	Tempo di incubazione	Formulazione	Descrizione dell'attività	PMID
DU-145	Growth Inhibition Assay				IC50=3.27352 μM	SANGER
HuO-3N1	Growth Inhibition Assay				IC50=4.17142 μM	SANGER
LAMA-84	Growth Inhibition Assay				IC50=4.58465 μM	SANGER
CAL-72	Growth Inhibition Assay				IC50=5.48084 μM	SANGER
LoVo	Growth Inhibition Assay				IC50=6.93239 μM	SANGER
HH	Growth Inhibition Assay				IC50=8.27671 μM	SANGER
SK-MEL-3	Growth Inhibition Assay				IC50=8.28575 μM	SANGER
KM12	Growth Inhibition Assay				IC50=9.21142 μM	SANGER
NCI-H1437	Growth Inhibition Assay				IC50=9.8097 μM	SANGER
NCI-H1838	Growth Inhibition Assay				IC50=11.1865 μM	SANGER
J-RT3-T3-5	Growth Inhibition Assay				IC50=11.2417 μM	SANGER
GOTO	Growth Inhibition Assay				IC50=11.6996 μM	SANGER
LB2241-RCC	Growth Inhibition Assay				IC50=11.7186 μM	SANGER
ES7	Growth Inhibition Assay				IC50=11.788 μM	SANGER
KP-N-YS	Growth Inhibition Assay				IC50=12.6354 μM	SANGER
CAL-12T	Growth Inhibition Assay				IC50=13.617 μM	SANGER
COLO-684	Growth Inhibition Assay				IC50=14.1569 μM	SANGER
DOK	Growth Inhibition Assay				IC50=15.3329 μM	SANGER
Hs-578-T	Growth Inhibition Assay				IC50=15.4182 μM	SANGER
D-423MG	Growth Inhibition Assay				IC50=15.5236 μM	SANGER
DBTRG-05MG	Growth Inhibition Assay				IC50=15.6111 μM	SANGER
VM-CUB-1	Growth Inhibition Assay				IC50=15.9849 μM	SANGER
KG-1	Growth Inhibition Assay				IC50=16.0996 μM	SANGER
8305C	Growth Inhibition Assay				IC50=16.1889 μM	SANGER
HuH-7	Growth Inhibition Assay				IC50=16.2674 μM	SANGER
LXF-289	Growth Inhibition Assay				IC50=16.2747 μM	SANGER
NCI-H1793	Growth Inhibition Assay				IC50=16.4712 μM	SANGER
ChaGo-K-1	Growth Inhibition Assay				IC50=16.6568 μM	SANGER
GCIY	Growth Inhibition Assay				IC50=16.7905 μM	SANGER
SK-MEL-28	Growth Inhibition Assay				IC50=17.0475 μM	SANGER
NCI-SNU-1	Growth Inhibition Assay				IC50=17.1269 μM	SANGER
CTB-1	Growth Inhibition Assay				IC50=17.2259 μM	SANGER
NCI-H82	Growth Inhibition Assay				IC50=17.4573 μM	SANGER
HCC2998	Growth Inhibition Assay				IC50=17.6733 μM	SANGER
NCI-H2030	Growth Inhibition Assay				IC50=18.1997 μM	SANGER
HuP-T3	Growth Inhibition Assay				IC50=18.5888 μM	SANGER
697	Growth Inhibition Assay				IC50=19.0201 μM	SANGER
MLMA	Growth Inhibition Assay				IC50=19.0557 μM	SANGER
HCC70	Growth Inhibition Assay				IC50=19.489 μM	SANGER
A704	Growth Inhibition Assay				IC50=19.8305 μM	SANGER
D-283MED	Growth Inhibition Assay				IC50=20.5339 μM	SANGER
U031	Growth Inhibition Assay				IC50=21.1489 μM	SANGER
HSC-3	Growth Inhibition Assay				IC50=21.1835 μM	SANGER
JVM-3	Growth Inhibition Assay				IC50=22.506 μM	SANGER
Mewo	Growth Inhibition Assay				IC50=22.5073 μM	SANGER
YH-13	Growth Inhibition Assay				IC50=22.5123 μM	SANGER
LB1047-RCC	Growth Inhibition Assay				IC50=22.5879 μM	SANGER
HCC2157	Growth Inhibition Assay				IC50=22.8054 μM	SANGER
SNU-449	Growth Inhibition Assay				IC50=22.8748 μM	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay				IC50=22.96 μM	SANGER
CHL-1	Growth Inhibition Assay				IC50=23.7292 μM	SANGER
SK-MEL-30	Growth Inhibition Assay				IC50=24.4662 μM	SANGER
PANC-08-13	Growth Inhibition Assay				IC50=25.0938 μM	SANGER
QIMR-WIL	Growth Inhibition Assay				IC50=25.1858 μM	SANGER
BFTC-905	Growth Inhibition Assay				IC50=25.5944 μM	SANGER
GI-1	Growth Inhibition Assay				IC50=25.7055 μM	SANGER
MDA-MB-415	Growth Inhibition Assay				IC50=26.5033 μM	SANGER
GT3TKB	Growth Inhibition Assay				IC50=26.5342 μM	SANGER
DEL	Growth Inhibition Assay				IC50=26.8356 μM	SANGER
KOSC-2	Growth Inhibition Assay				IC50=26.9075 μM	SANGER
RVH-421	Growth Inhibition Assay				IC50=27.2921 μM	SANGER
EW-13	Growth Inhibition Assay				IC50=27.4308 μM	SANGER
639-V	Growth Inhibition Assay				IC50=27.5119 μM	SANGER
A2780	Growth Inhibition Assay				IC50=27.641 μM	SANGER
SW982	Growth Inhibition Assay				IC50=27.9052 μM	SANGER
SW1710	Growth Inhibition Assay				IC50=28.0981 μM	SANGER
HCC1569	Growth Inhibition Assay				IC50=28.4897 μM	SANGER
MV-4-11	Growth Inhibition Assay				IC50=28.5735 μM	SANGER
BHT-101	Growth Inhibition Assay				IC50=28.6572 μM	SANGER
Ca9-22	Growth Inhibition Assay				IC50=28.714 μM	SANGER
HAL-01	Growth Inhibition Assay				IC50=28.7615 μM	SANGER
D-263MG	Growth Inhibition Assay				IC50=29.344 μM	SANGER
NEC8	Growth Inhibition Assay				IC50=29.5548 μM	SANGER
EKVX	Growth Inhibition Assay				IC50=31.5847 μM	SANGER
EM-2	Growth Inhibition Assay				IC50=31.6304 μM	SANGER
MFM-223	Growth Inhibition Assay				IC50=31.8098 μM	SANGER
SK-PN-DW	Growth Inhibition Assay				IC50=32.1406 μM	SANGER
HuO9	Growth Inhibition Assay				IC50=32.5282 μM	SANGER
MHH-PREB-1	Growth Inhibition Assay				IC50=32.6234 μM	SANGER
OVCAR-4	Growth Inhibition Assay				IC50=32.8363 μM	SANGER
NCI-H1648	Growth Inhibition Assay				IC50=32.8651 μM	SANGER
MKN1	Growth Inhibition Assay				IC50=34.1101 μM	SANGER
KYSE-450	Growth Inhibition Assay				IC50=34.6444 μM	SANGER
ES8	Growth Inhibition Assay				IC50=34.8975 μM	SANGER
MS-1	Growth Inhibition Assay				IC50=34.9554 μM	SANGER
HOP-92	Growth Inhibition Assay				IC50=35.9277 μM	SANGER
SKG-IIIa	Growth Inhibition Assay				IC50=36.2561 μM	SANGER
TE-11	Growth Inhibition Assay				IC50=36.5243 μM	SANGER
SK-NEP-1	Growth Inhibition Assay				IC50=37.6744 μM	SANGER
DB	Growth Inhibition Assay				IC50=37.9185 μM	SANGER
IA-LM	Growth Inhibition Assay				IC50=38.0239 μM	SANGER
COLO-829	Growth Inhibition Assay				IC50=38.4159 μM	SANGER
TGBC11TKB	Growth Inhibition Assay				IC50=39.1408 μM	SANGER
CAL-51	Growth Inhibition Assay				IC50=40.0612 μM	SANGER
NCI-H2228	Growth Inhibition Assay				IC50=40.3662 μM	SANGER
C32	Growth Inhibition Assay				IC50=40.4024 μM	SANGER
KU-19-19	Growth Inhibition Assay				IC50=40.7683 μM	SANGER
KNS-62	Growth Inhibition Assay				IC50=40.8381 μM	SANGER
FADU	Growth Inhibition Assay				IC50=41.2502 μM	SANGER
CAL-33	Growth Inhibition Assay				IC50=42.6749 μM	SANGER
CHP-134	Growth Inhibition Assay				IC50=42.8496 μM	SANGER
HDLM-2	Growth Inhibition Assay				IC50=42.9084 μM	SANGER
NBsusSR	Growth Inhibition Assay				IC50=43.0725 μM	SANGER
SW954	Growth Inhibition Assay				IC50=43.1053 μM	SANGER
HCC1806	Growth Inhibition Assay				IC50=43.411 μM	SANGER
VMRC-RCZ	Growth Inhibition Assay				IC50=43.4586 μM	SANGER
A549	Growth Inhibition Assay				IC50=43.931 μM	SANGER
NKM-1	Growth Inhibition Assay				IC50=43.9558 μM	SANGER
DMS-273	Growth Inhibition Assay				IC50=44.7567 μM	SANGER
TYK-nu	Growth Inhibition Assay				IC50=45.1234 μM	SANGER
KALS-1	Growth Inhibition Assay				IC50=45.146 μM	SANGER
A101D	Growth Inhibition Assay				IC50=45.4456 μM	SANGER
G-361	Growth Inhibition Assay				IC50=46.2138 μM	SANGER
KARPAS-299	Growth Inhibition Assay				IC50=46.3516 μM	SANGER
RS4-11	Growth Inhibition Assay				IC50=46.542 μM	SANGER
HT-1376	Growth Inhibition Assay				IC50=46.7426 μM	SANGER
SK-N-AS	Growth Inhibition Assay				IC50=46.7822 μM	SANGER
MG-63	Growth Inhibition Assay				IC50=46.9036 μM	SANGER
EPLC-272H	Growth Inhibition Assay				IC50=46.9503 μM	SANGER
BALL-1	Growth Inhibition Assay				IC50=47.832 μM	SANGER
LCLC-97TM1	Growth Inhibition Assay				IC50=48.202 μM	SANGER
HO-1-N-1	Growth Inhibition Assay				IC50=48.9676 μM	SANGER
MFE-280	Growth Inhibition Assay				IC50=49.4617 μM	SANGER
NCI-H526	Growth Inhibition Assay				IC50=49.8163 μM	SANGER
D-566MG	Growth Inhibition Assay				IC50=49.9096 μM	SANGER
BB30-HNC	Growth Inhibition Assay				IC50=49.9498 μM	SANGER
SK-N-DZ	Growth Inhibition Assay				IC50=50.0481 μM	SANGER
HepG2	Growth Inhibition Assay	10 μM	24 h		blocks SC-III3-induced S phase arrest	25527123
HepG2	Function Assay	10 μM	24 h		suppresses the phosphorylations of ATM on Ser1981, Chk1 on Ser345, Chk2 on Thr68, and Cdk2 on Tyr15 induced by SC-III3	25527123
KATO III	Growth Inhibition Assay	2.5/5/7.5 μM		DMSO	enhances the toxicity of olaparib	24841718
hTCEpi	Growth Inhibition Assay	10 μM		DMSO	prevents the cytopathic effect of HSV-1	24370835
MCF10A	Growth Inhibition Assay	10 μM	24 h	DMSO	potentiates the cytotoxicity of GA	24150595
HL-60	Function Assay	10 μM	0.5 h	DMSO	reduces phosphorylation of Chk2	23934411
MCF-7	Growth Inhibition Assay	1-100μM	24 h	FBS	inhibits the cell proliferation	23185347
HeLa	Growth Inhibition Assay	1-100μM	24 h	FBS	inhibits the cell proliferation	23185347
SH-SY5Y	Function Assay	10 μM	24 h		inhibits clioquinol-induced phosphorylation of p53	22627294
IMR-32	Function Assay	10 μM	24 h		inhibits clioquinol-induced phosphorylation of p53	22627294
A549	Function Assay	10 μM	1 h		suppresses Nano-Co-induced p53 accumulation	22559321
T47D	Function Assay	20 mM	24 h	DMSO	prevents IR-induced degradation of IκBα	21144805
A29 MEF	Function Assay	10 μM	1h		blocks the phosphorylation of Akt at Ser473	20053781
MDA-MB-453	Growth Inhibition Assay	5-40 μM	72 h		IC50 of 10 μM	20053781
PC-3	Growth Inhibition Assay	5-40 μM	72 h		IC50 of 10 μM	20053781
U2OS	Function assay				Inhibition of ATM in human U2OS cells assessed as inhibition of p53 phosphorylation at Ser15 residue, IC50 = 0.25 μM.	26632965
MCF7	Function assay		1 hr		Inhibition of ATM kinase in human MCF7 cells after 1 hr by immunofluorescence assay, IC50 = 0.3 μM.	26632965
BJ	Function assay	10 uM	10 days		Suppression of senescence in human BJ cells assessed as increase in cell number at 10 uM after 10 days by senescence reversal assay	16767085
BJ	Function assay	10 uM	10 days		Inhibition of ataxia telangiectasia-mutated in human BJ cells assessed as increase in cell number at 10 uM after 10 days by senescence reversal assay	16767085
MCF7	Function assay	10 uM	10 mins		Sensitization of infrared-induced DNA damage in human MCF7 cells assessed as reduction in colony formation at 10 uM pretreated for 10 mins followed by irradiation for 4 hrs measured after 10 days by crystal violet staining analysis	26632965
SK-N-MC	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	29435139
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Informazioni chimiche, conservazione e stabilità (Chemical Information, Storage & Stability)

Peso molecolare	395.49	Formula	C₂₁H₁₇NO₃S₂	Conservazione (Dalla data di ricezione)	3 anni-20°Cpolvere
N. CAS	587871-26-9	Scarica SDF		Conservazione delle soluzioni stock	1 anno-80°Cin solvente 1 mese-20°Cin solvente
Sinonimi	ATM Kinase Inhibitor			Smiles	C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

Solubilità (Solubility)

In vitro
Lotto:

DMSO : 39 mg/mL (98.61 mM)
(Il DMSO contaminato da umidità può ridurre la solubilità. Utilizzare DMSO fresco e anidro.)

Water : Insoluble

Ethanol : Insoluble

Calcolatore di Molarità

Massa	Concentrazione	Volume	Peso molecolare
=	×	×

Calcolatore di Diluizione Calcolatore del Peso Molecolare

In vivo Lotto:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validato dai laboratori Selleck. Se necessiti di modifiche a questa formulazione, contatta il nostro team di vendita per test personalizzati.	2.000mg/ml (5.06mM)	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validato dai laboratori Selleck. Se necessiti di modifiche a questa formulazione, contatta il nostro team di vendita per test personalizzati.	3.950mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of clarified DMSO stock solution of 79 mg/ml to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

Calcolatore di formulazione in vivo (Soluzione chiara)

Passo 1: Inserire le informazioni di seguito (Consigliato: Un animale aggiuntivo per tenere conto della perdita durante l'esperimento)

Dosaggio: mg/kg Peso medio degli animali: g Volume di dosaggio per animale:μL Numero di animali:

Passo 2: Inserire la formulazione in vivo (Questo è solo il calcolatore, non la formulazione. Contattateci prima se non c'è una formulazione in vivo nella sezione Solubilità.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Risultati del calcolo:

Concentrazione di lavoro: mg/ml;

Metodo per preparare il liquido master di DMSO: mg farmaco predissolto in μL DMSO ( Concentrazione del liquido master mg/mL, Vi preghiamo di contattarci prima se la concentrazione supera la solubilità del DMSO del lotto del farmaco. )

Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungereμL PEG300, mescolare e chiarire, quindi aggiungereμL Tween 80, mescolare e chiarire, quindi aggiungere μL ddH₂O, mescolare e chiarire.

Metodo per preparare la formulazione in vivo: Prendere μL DMSO liquido master, quindi aggiungere μL Olio di mais, mescolare e chiarire.

Nota: 1. Si prega di assicurarsi che il liquido sia limpido prima di aggiungere il solvente successivo.
2. Assicurarsi di aggiungere il/i solvente/i in ordine. È necessario assicurarsi che la soluzione ottenuta, nell'aggiunta precedente, sia una soluzione limpida prima di procedere all'aggiunta del solvente successivo. Metodi fisici come il vortex, gli ultrasuoni o il bagno d'acqua calda possono essere utilizzati per facilitare la dissoluzione.

Meccanismo d'azione (Mechanism of Action)

Targets/IC₅₀/Ki	ATM (Cell-free assay) 12.9 nM
In vitro	KU-55933 inhibits DNA-PK and PI3K with IC50 of 2.5 μM and 16.6 μM, respectively. Besides, this compound also prevents the activity of mTOR with IC50 of 9.3 μM. It is active at the cellular level in ablating a well-characterized ATM-dependent phosphorylation event. This chemical has a dose-dependent effect in inhibiting this ATM-dependent phosphorylation event with IC50 of 300 nM. KU-58050 does not prevent the ATM-dependent phosphorylation of p53 serine 15 until a dose of 30 μM. Addition of this compound has no appreciable effects on UV-induced phosphorylation of H2AX on serine 139, NBS1 on serine 343, CHK1 on serine 345, and SMC1 on serine 966. In stark contrast to the UV responses, it ablates the ionizing radiation-induced phosphorylation of these ATM substrates. This chemical sensitizes HeLa cells to a range of ionizing radiation doses. It inhibits the phosphorylation of Akt induced by growth factors in cancer cells. This compound suppresses the proliferation of cancer cells. Furthermore, suppression of ATM by this chemical improves survival, probably via prevention of downstream activation of TAp63α.
Saggio chinasico	Saggi enzimatici purificati
Saggio chinasico	L'ATM da utilizzare nel saggio in vitro è ottenuta dall'estratto nucleare di HeLa mediante immunoprecipitazione con antisiero policlonale di coniglio elevato contro i 400 amminoacidi COOH-terminali di ATM in un tampone contenente 25 mM HEPES (pH 7.4), 2 mM MgCl₂, 250 mM KCl, 500 μM EDTA, 100 μM Na₃VO₄, 10% v/v glicerolo e 0.1% v/v Igepal. I complessi ATM-anticorpo sono isolati dall'estratto nucleare incubando con perle di proteina A-Sepharose per 1 ora e poi mediante centrifugazione per recuperare le perle. Nel pozzetto di una piastra a 96 pozzetti, le perle di Sepharose contenenti ATM vengono incubate con 1 μg di substrato glutatione S-transferasi–p53N66 (66 amminoacidi NH₂-terminali di p53 fusi alla glutatione S-transferasi) in tampone di saggio ATM [25 mM HEPES (pH 7.4), 75 mM NaCl, 3 mM MgCl₂, 2 mM MnCl₂, 50 μM Na₃VO₄, 500 μM DTT e 5% v/v glicerolo] a 37 °C in presenza o assenza di questo composto. Dopo 10 minuti con agitazione delicata, l'ATP viene aggiunto a una concentrazione finale di 50 μM e la reazione continua a 37 °C per un'altra ora. La piastra viene centrifugata a 250 × g per 10 minuti (4 °C) per rimuovere le perle contenenti ATM, e il surnatante viene rimosso e trasferito in una piastra opaca bianca a 96 pozzetti e incubato a temperatura ambiente per 1.5 ore per consentire il legame della glutatione S-transferasi-p53N66. Questa piastra viene quindi lavata con PBS, asciugata e analizzata mediante una tecnica ELISA standard con un anticorpo anti-p53 fosfo-serina 15. La rilevazione del substrato glutatione S-transferasi-p53N66 fosforilato viene eseguita in combinazione con un anticorpo secondario di capra anti-topo coniugato con perossidasi di rafano. Una soluzione di chemiluminescenza potenziata viene utilizzata per produrre un segnale e viene eseguita la rilevazione chemiluminescente.
In vivo	Suppression of ATM-dependent STAT3 activation by KU-55933 enhances TRAIL-mediated apoptosis through up-regulation of surface DR5 expression, whereas suppression of both STAT3 and NF-κB appeares to be involved in down-regulation of cFLIP accompanied by an additional increase in apoptotic levels. This compound affects TRAIL-mediated apoptosis more strongly than the JAK2 inhibitor, AG490, or overexpression of STAT3β.
Riferimenti	[1] https://pubmed.ncbi.nlm.nih.gov/15604286/ [2] https://pubmed.ncbi.nlm.nih.gov/21869459/ [3] https://pubmed.ncbi.nlm.nih.gov/19351839/

Applicazioni (Applications)

Metodi	Biomarcatori	Immagini	PMID
Western blot	p-AKT(Ser473) / p-AKT(Thr308) PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ATM-S1981 / ATM / p-p53(S15) / p53 p21 / p27 / p53		22739265
Immunofluorescence	p-S824 KAP1 / ZEBRA		28249048

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):